(data stored in ACNUC5719 zone)

HOGENOM: HSX_PE44

ID   HSX_PE44                             STANDARD;      PRT;   621 AA.
AC   HSX_PE44; O95671; Q5JQ53; Q8NBH5; Q96G02; Q9BUL6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=N-acetylserotonin O-methyltransferase-like protein;
DE   Short=ASMTL; (HSX.PE44).
GN   Name=ASMTL;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HSX.PE44.
CC       Homo sapiens chromosome X GRCh37  sequence 1..155260560 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ASML_HUMAN
CC   -!- FUNCTION: Unknown. The presence of the putative catalytic domain
CC       of S-adenosyl-L-methionine binding argues for a methyltransferase
CC       activity.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O95671-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O95671-2; Sequence=VSP_007213;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Widely expressed. In adult, highly expressed
CC       in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary
CC       and colon. Expressed at lower levels in spleen, small intestine
CC       and leukocytes. In fetus, expressed at high levels in the lung and
CC       kidney and at lower level in brain and liver.
CC   -!- MISCELLANEOUS: The gene encoding for this protein is located in
CC       the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It
CC       represents a unique fusion product of 2 different genes of
CC       different evolutionary origin and function. The N-terminus is
CC       homologous to the bacterial maf/orfE genes and the C-terminus is
CC       homologous to ASMT. Exon duplication, exon shuffling and gene
CC       fusion seem to be common characteristics of the PAR1 region.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the maf family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA75675.1; Type=Frameshift; Positions=616;
CC       Sequence=CAA75676.1; Type=Frameshift; Positions=616;
CC   -!- GENE_FAMILY: HOG000034104 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000169093;ENST00000381317;ENSP00000370718.
DR   EMBL; AK001090; - ;
DR   EMBL; AK090498; - ;
DR   EMBL; AK299231; - ;
DR   EMBL; AK301844; - ;
DR   EMBL; AL683870; - ;
DR   EMBL; BC002508; - ;
DR   EMBL; BC010089; - ;
DR   EMBL; Y15521; - ;
DR   UniProtKB/Swiss-Prot; O95671; Q5JQ53; Q8NBH5; Q96G02; Q9BUL6; -.
DR   EMBL; Y15521; CAA75675.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; Y15521; CAA75676.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AK090498; BAC03468.1; -; mRNA.
DR   EMBL; AL683870; CAI39847.1; -; Genomic_DNA.
DR   EMBL; BC002508; AAH02508.1; -; mRNA.
DR   EMBL; BC010089; AAH10089.1; -; mRNA.
DR   IPI; IPI00249080; -.
DR   IPI; IPI00479385; -.
DR   RefSeq; NP_001166945.1; NM_001173474.1.
DR   RefSeq; NP_004183.2; NM_004192.3.
DR   UniGene; Hs.533514; -.
DR   PDB; 2P5X; X-ray; 2.00 A; A/B=10-239.
DR   PDBsum; 2P5X; -.
DR   ProteinModelPortal; O95671; -.
DR   SMR; O95671; 10-213, 285-619.
DR   IntAct; O95671; 2.
DR   STRING; O95671; -.
DR   PhosphoSite; O95671; -.
DR   PRIDE; O95671; -.
DR   Ensembl; ENST00000381317; ENSP00000370718; ENSG00000169093.
DR   GeneID; 8623; -.
DR   KEGG; hsa:8623; -.
DR   UCSC; uc004cpx.1; human.
DR   UCSC; uc004cpy.1; human.
DR   CTD; 8623; -.
DR   GeneCards; GC0XM001522; -.
DR   HGNC; HGNC:751; ASMTL.
DR   HPA; HPA003630; -.
DR   HPA; HPA021865; -.
DR   MIM; 300162; gene.
DR   MIM; 400011; gene.
DR   neXtProt; NX_O95671; -.
DR   eggNOG; prNOG20334; -.
DR   GeneTree; ENSGT00530000064032; -.
DR   InParanoid; O95671; -.
DR   OMA; HLKTPDI; -.
DR   PhylomeDB; O95671; -.
DR   NextBio; 32321; -.
DR   ArrayExpress; O95671; -.
DR   Bgee; O95671; -.
DR   CleanEx; HS_ASMTL; -.
DR   Genevestigator; O95671; -.
DR   GermOnline; ENSG00000169093; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0017096; F:acetylserotonin O-methyltransferase activity; NAS:UniProtKB.
DR   GO; GO:0030187; P:melatonin biosynthetic process; TAS:UniProtKB.
DR   InterPro; IPR003697; Maf.
DR   InterPro; IPR001077; O_MeTrfase_2.
DR   InterPro; IPR011991; WHTH_trsnscrt_rep_DNA-bd.
DR   Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
DR   Pfam; PF02545; Maf; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   TIGRFAMs; TIGR00172; Maf; 1.
DR   HOGENOMDNA; HSX.PE44; -.
KW   ENSG000001690931755old_1320000031; ENSP000003707187901old_1320000031;
KW   B3KM43_HUMAN; B4DRF1_HUMAN; B4DX75_HUMAN; AK001090; AK090498; AK299231;
KW   AL683870; BC002508; BC010089; Y15521;
KW   3D-structure; Alternative splicing; Complete proteome; Phosphoprotein;
KW   Polymorphism; Reference proteome.
SQ   SEQUENCE   621 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME
     TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGREHS
     VFTGVAIVHC SSKDHQLDTR VSEFYEETKV KFSELSEELL WEYVHSGEPM DKAGGYGIQA
     LGGMLVESVH GDFLNVVGFP LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD
     VEGGGSEPTQ RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
     LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK TEQGYSNTET
     ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN QHHRALGKKA EDLFQDAYYQ
     SPETRLRFMR AMHGMTKLTA CQVATAFNLS RFSSACDVGG CTGALARELA REYPRMQVTV
     FDLPDIIELA AHFQPPGPQA VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS
     RVAESCKPGA GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
     QVQVVHLGGV LDAILATKVA P
//

If you have problems or comments...

PBIL Back to PBIL home page