(data stored in ACNUC12215 zone)

HOGENOM: HSX_PE542

ID   HSX_PE542                            STANDARD;      PRT;   444 AA.
AC   HSX_PE542; P51811; Q4TTN6; Q8IUK6; Q9UC77;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Membrane transport protein XK;AltName: Full=Kell complex 37
DE   kDa component;AltName: Full=Kx antigen;AltName: Full=XK-related protein
DE   1; (HSX.PE542).
GN   Name=XK; Synonyms=XKR1, XRG1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HSX.PE542.
CC       Homo sapiens chromosome X GRCh37  sequence 1..155260560 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:XK_HUMAN
CC   -!- FUNCTION: May be involved in sodium-dependent transport of neutral
CC       amino acids or oligopeptides.
CC   -!- SUBUNIT: Heterodimer with Kell; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- TISSUE SPECIFICITY: High levels in skeletal muscle, heart, brain,
CC       and pancreas; low levels in placenta, lung, liver, and kidney.
CC   -!- PTM: Not glycosylated.
CC   -!- POLYMORPHISM: XK is responsible for the Kx blood group system.
CC   -!- DISEASE: Defects in XK are the cause of McLeod syndrome (MLS)
CC       [MIM:300842]. It is an X-linked multisystem disorder characterized
CC       by late onset abnormalities in the neuromuscular and hematopoietic
CC       systems.
CC   -!- SIMILARITY: Belongs to the XK family.
CC   -!- WEB RESOURCE: Name=GeneReviews;
CC       URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/XK";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/xk/";
CC   -!- GENE_FAMILY: HOG000118070 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000047597;ENST00000378616;ENSP00000367879.
DR   EMBL; AB214532; - ;
DR   EMBL; AY534238; - ;
DR   EMBL; BC036019; - ;
DR   EMBL; DQ062746; - ;
DR   EMBL; Z32684; - ;
DR   UniProtKB/Swiss-Prot; P51811; Q4TTN6; Q8IUK6; Q9UC77; -.
DR   EMBL; Z32684; CAA83632.2; -; mRNA.
DR   EMBL; AY534238; AAT07087.1; -; mRNA.
DR   EMBL; DQ062746; AAY43132.1; -; Genomic_DNA.
DR   EMBL; BC036019; AAH36019.1; -; mRNA.
DR   IPI; IPI00020896; -.
DR   PIR; I39294; I39294.
DR   RefSeq; NP_066569.1; NM_021083.2.
DR   UniGene; Hs.78919; -.
DR   ProteinModelPortal; P51811; -.
DR   STRING; P51811; -.
DR   TCDB; 9.B.5.1.1; KX blood-group antigen (KXA) family.
DR   PRIDE; P51811; -.
DR   Ensembl; ENST00000378616; ENSP00000367879; ENSG00000047597.
DR   GeneID; 7504; -.
DR   KEGG; hsa:7504; -.
DR   UCSC; uc004ddq.1; human.
DR   CTD; 7504; -.
DR   GeneCards; GC0XP035290; -.
DR   H-InvDB; HIX0028449; -.
DR   HGNC; HGNC:12811; XK.
DR   HPA; HPA019036; -.
DR   MIM; 300842; phenotype.
DR   MIM; 314850; gene.
DR   neXtProt; NX_P51811; -.
DR   Orphanet; 59306; McLeod neuroacanthocytosis syndrome.
DR   PharmGKB; PA37410; -.
DR   eggNOG; prNOG17742; -.
DR   InParanoid; P51811; -.
DR   OMA; GKLFTHR; -.
DR   OrthoDB; EOG40ZQXS; -.
DR   PhylomeDB; P51811; -.
DR   NextBio; 29381; -.
DR   ArrayExpress; P51811; -.
DR   Bgee; P51811; -.
DR   CleanEx; HS_XK; -.
DR   Genevestigator; P51811; -.
DR   GermOnline; ENSG00000047597; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; TAS:HGNC.
DR   GO; GO:0005515; F:protein binding; IPI:HGNC.
DR   GO; GO:0005215; F:transporter activity; TAS:ProtInc.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR018629; Transport_prot_XK.
DR   Pfam; PF09815; XK-related; 1.
DR   HOGENOMDNA; HSX.PE542; -.
KW   ENSG000000475971755old_1320000031; ENSP000003678797901old_1320000031;
KW   Q2Z218_HUMAN; AB214532; AY534238; BC036019; DQ062746; Z32684;
KW   Amino-acid transport; Blood group antigen; Complete proteome;
KW   Direct protein sequencing; Disease mutation; Disulfide bond; Membrane;
KW   Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
SQ   SEQUENCE   444 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKFPASVLAS VFLFVAETTA ALSLSSTYRS GGDRMWQALT LLFSLLPCAL VQLTLLFVHR
     DLSRDRPLVL LLHLLQLGPL FRCFEVFCIY FQSGNNEEPY VSITKKRQMP KNGLSEEIEK
     EVGQAEGKLI THRSAFSRAS VIQAFLGSAP QLTLQLYISV MQQDVTVGRS LLMTISLLSI
     VYGALRCNIL AIKIKYDEYE VKVKPLAYVC IFLWRSFEIA TRVVVLVLFT SVLKTWVVVI
     ILINFFSFFL YPWILFWCSG SPFPENIEKA LSRVGTTIVL CFLTLLYTGI NMFCWSAVQL
     KIDSPDLISK SHNWYQLLVY YMIRFIENAI LLLLWYLFKT DIYMYVCAPL LVLQLLIGYC
     TAILFMLVFY QFFHPCKKLF SSSVSEGFQR WLRCFCWACR QQKPCEPIGK EDLQSSRDRD
     ETPSSSKTSP EPGQFLNAED LCSA
//

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