(data stored in ACNUC1130 zone)

HOGENOM: HSX_PE627

ID   HSX_PE627                            STANDARD;      PRT;   777 AA.
AC   HSX_PE627; Q5JST6; Q5JST8; Q68DK4; Q8NEI0; Q9H653;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=EF-hand domain-containing family member C2; (HSX.PE627).
GN   Name=EFHC2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HSX.PE627.
CC       Homo sapiens chromosome X GRCh37  sequence 1..155260560 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:EFHC2_HUMAN
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5JST6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5JST6-2; Sequence=VSP_020766;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Contains 3 DM10 domains.
CC   -!- SIMILARITY: Contains 1 EF-hand domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI40213.1; Type=Erroneous initiation;
CC       Sequence=CAI42234.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000265451 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000183690;ENST00000420999;ENSP00000404232.
DR   EMBL; AC018719; - ;
DR   EMBL; AK026254; - ;
DR   EMBL; AK026496; - ;
DR   EMBL; AK291187; - ;
DR   EMBL; AK292967; - ;
DR   EMBL; AL133344; - ;
DR   EMBL; AL359744; - ;
DR   EMBL; BC031039; - ;
DR   EMBL; CR749363; - ;
DR   UniProtKB/Swiss-Prot; Q5JST6; Q5JST8; Q68DK4; Q8NEI0; Q9H653; -.
DR   EMBL; AK026254; BAB15413.1; -; mRNA.
DR   EMBL; AL359744; CAI40211.1; -; Genomic_DNA.
DR   EMBL; AL133344; CAI40211.1; JOINED; Genomic_DNA.
DR   EMBL; AL359744; CAI40213.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AC018719; CAI40213.1; JOINED; Genomic_DNA.
DR   EMBL; AL133344; CAI40213.1; JOINED; Genomic_DNA.
DR   EMBL; AL133344; CAI42232.1; -; Genomic_DNA.
DR   EMBL; AL359744; CAI42232.1; JOINED; Genomic_DNA.
DR   EMBL; AL133344; CAI42234.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AC018719; CAI42234.1; JOINED; Genomic_DNA.
DR   EMBL; AL359744; CAI42234.1; JOINED; Genomic_DNA.
DR   EMBL; BC031039; AAH31039.1; -; mRNA.
DR   EMBL; CR749363; CAH18216.1; -; mRNA.
DR   IPI; IPI00171599; -.
DR   IPI; IPI00646148; -.
DR   RefSeq; NP_079460.2; NM_025184.3.
DR   UniGene; Hs.521953; -.
DR   PDB; 2Z13; X-ray; 1.84 A; A=71-190.
DR   PDB; 2Z14; X-ray; 1.68 A; A=71-190.
DR   PDBsum; 2Z13; -.
DR   PDBsum; 2Z14; -.
DR   ProteinModelPortal; Q5JST6; -.
DR   SMR; Q5JST6; 71-189, 422-542, 560-698.
DR   IntAct; Q5JST6; 2.
DR   STRING; Q5JST6; -.
DR   PRIDE; Q5JST6; -.
DR   Ensembl; ENST00000333807; ENSP00000333823; ENSG00000183690.
DR   Ensembl; ENST00000420999; ENSP00000404232; ENSG00000183690.
DR   GeneID; 80258; -.
DR   KEGG; hsa:80258; -.
DR   CTD; 80258; -.
DR   GeneCards; GC0XM041736; -.
DR   H-InvDB; HIX0016743; -.
DR   HGNC; HGNC:26233; EFHC2.
DR   HPA; HPA034492; -.
DR   MIM; 300817; gene.
DR   neXtProt; NX_Q5JST6; -.
DR   PharmGKB; PA134938637; -.
DR   eggNOG; prNOG06466; -.
DR   InParanoid; Q5JST6; -.
DR   OrthoDB; EOG4GF3F1; -.
DR   PhylomeDB; Q5JST6; -.
DR   NextBio; 70713; -.
DR   ArrayExpress; Q5JST6; -.
DR   Bgee; Q5JST6; -.
DR   CleanEx; HS_EFHC2; -.
DR   Genevestigator; Q5JST6; -.
DR   GermOnline; ENSG00000183690; Homo sapiens.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR010554; DUF1126.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR006602; Uncharacterised_DM10.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF06565; DUF1126; 3.
DR   SMART; SM00676; DM10; 3.
DR   PROSITE; PS51336; DM10; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   HOGENOMDNA; HSX.PE627; -.
KW   ENSG000001836901755old_1320000031; ENSP000004042327901old_1320000031;
KW   A8K572_HUMAN; A8KAA2_HUMAN; Q9H5X5_HUMAN; AC018719; AK026254; AK026496;
KW   AK292967; AL133344; AL359744; BC031039; CR749363;
KW   3D-structure; Alternative splicing; Complete proteome; Polymorphism;
KW   Reference proteome; Repeat.
SQ   SEQUENCE   777 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     GGQTTRPGGA AACRALSSGT LDFRTLSAMA LPLLPGNSFN RNVGKEKFHK SQHWGFCNNV
     MMLVSDEKPG IGGEPLLGQK IKPKCSIYPK GDGSDVPSWV AFDKQVLSFD AYLEEEVLDK
     SQTNYRIRYY KIYFYPEDDT IQVNEPEVKN SGLLQGTSIR RHRITLPPPD EDQFYTVYHF
     NVGTEVVFYG RTFKIYDCDA FTRNFLRKIG VKVNPPVQCP EDPYMKIRRE VVEHVEPLRP
     YESLDTLKQF LQYHGKILCF FCLWDDSVSM FGDRRELILH YFLCDDTIEI KELLPHSSGR
     DALKMFLRRS KLPKNCPPRV YQPGQITDRA VLNSYGDFIK NQADGYLFDR YKLGKVDQEF
     YKDSDLSLGV TINVWGRKVL LYDCDEFTKS YYKSKYGIEN FTSVSCKPPS PPPKIERKFP
     PYNGFGSEED SLRNCIDLKP TPHRRNFKKF MEKDSYGSKS NILRFFAKLV TDKCVDLDRM
     FVISYYLGDD TISVFEPIER NSGIAGGMFL KRSRVKKPGQ EVFKSELSEY IKAEELYIGV
     TVNVNGYLFR LLNADEYTLN YMEQNTDKYP FSNLKLALQK LKQEEGKSRE LKQVFKAADS
     KHTNMVDYNT FRDILMSLTV GNLAEQEFVT IARHYRVPEG TCSDMDFLIA LAHEKFKKNM
     FENFDTFIYS CVYEDREKKN VLPTKDIKRL CKSSRLPLSD DLLESLLSRF EDSEKQIDYK
     SFFSALNWRK NPVPELQPAS YLKERCEDVW LGMPSPIPAK YIDYWTFLKD AFGLEEE
//

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