(data stored in ACNUC15465 zone)

HOGENOM: HSX_PE955

ID   HSX_PE955                            STANDARD;      PRT;   116 AA.
AC   HSX_PE955; Q13066; C9K0W9; Q4V322;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=G antigen 2B/2C; Short=GAGE-2B; Short=GAGE-2C;AltName:
DE   Full=Cancer/testis antigen 4.2; Short=CT4 2;AltName: Full=G antigen 2C;
DE   (HSX.PE955).
GN   Name=GAGE2B; Synonyms=GAGE2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HSX.PE955.
CC       Homo sapiens chromosome X GRCh37  sequence 1..155260560 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:GAG2B_HUMAN
CC   -!- FUNCTION: Antigen, recognized on melanoma by autologous cytolytic
CC       T-lymphocytes.
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of tumor tissues but
CC       not in normal tissues, except testis.
CC   -!- MISCELLANEOUS: This gene belongs to a family of genes organized in
CC       clustered repeats. They have a high degree of predicted sequence
CC       identity, but differ by scattered single nucleotide substitution.
CC       Their sequences contain either the antigenic peptide YYWPRPRRY or
CC       YRPRPRRY which is recognized by cytotoxic T cells.
CC   -!- SIMILARITY: Belongs to the GAGE family.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made
CC       impossible to separate products of paralogous genes from polymorph
CC       products. PubMed:18179644 presented a new GAGE gene nomenclature
CC       based on the identified genes and their products.
CC   -!- GENE_FAMILY: HOG000237345 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000236249;ENST00000381708;ENSP00000371127.
DR   EMBL; BC069309; - ;
DR   EMBL; BC069558; - ;
DR   EMBL; BC113926; - ;
DR   EMBL; BX649339; - ;
DR   EMBL; U19143; - ;
DR   UniProtKB/Swiss-Prot; Q13066; C9K0W9; Q4V322; -.
DR   EMBL; U19143; AAA82745.1; -; mRNA.
DR   EMBL; BX649339; CAI95424.1; -; Genomic_DNA.
DR   EMBL; BX649339; CAI95425.1; -; Genomic_DNA.
DR   EMBL; BC069309; AAH69309.1; -; mRNA.
DR   EMBL; BC069558; AAH69558.1; -; mRNA.
DR   EMBL; BC113926; AAI13927.1; -; mRNA.
DR   IPI; IPI00011527; -.
DR   RefSeq; NP_001463.1; NM_001472.2.
DR   UniGene; Hs.460641; -.
DR   UniGene; Hs.714681; -.
DR   UniGene; Hs.722100; -.
DR   ProteinModelPortal; Q13066; -.
DR   STRING; Q13066; -.
DR   PhosphoSite; Q13066; -.
DR   PRIDE; Q13066; -.
DR   Ensembl; ENST00000376179; ENSP00000365350; ENSG00000236249.
DR   Ensembl; ENST00000381708; ENSP00000371127; ENSG00000236249.
DR   Ensembl; ENST00000381725; ENSP00000371144; ENSG00000231850.
DR   Ensembl; ENST00000407783; ENSP00000385617; ENSG00000236249.
DR   GeneID; 2574; -.
DR   KEGG; hsa:2574; -.
DR   UCSC; uc004dnr.2; human.
DR   CTD; 2574; -.
DR   GeneCards; GC0XP049218; -.
DR   GeneCards; GC0XP049235; -.
DR   HGNC; HGNC:31957; GAGE2B.
DR   HGNC; HGNC:31958; GAGE2C.
DR   MIM; 300595; gene.
DR   MIM; 300726; gene.
DR   neXtProt; NX_Q13066; -.
DR   PharmGKB; PA162389260; -.
DR   GeneTree; ENSGT00530000063902; -.
DR   OrthoDB; EOG40S0HR; -.
DR   NextBio; 10179; -.
DR   CleanEx; HS_GAGE2B; -.
DR   Genevestigator; Q13066; -.
DR   GermOnline; ENSG00000205775; Homo sapiens.
DR   GermOnline; ENSG00000205777; Homo sapiens.
DR   InterPro; IPR008625; GAGE.
DR   Pfam; PF05831; GAGE; 1.
DR   HOGENOMDNA; HSX.PE955; -.
KW   ENSG000002362491755old_1320000031; ENSP000003711277901old_1320000031;
KW   BC069309; BC069558; BC113926; BX649339; U19143;
KW   Complete proteome; Phosphoprotein; Reference proteome.
SQ   SEQUENCE   116 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGED
     EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN PEEVKTPEEG EKQSQC
//

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