(data stored in ACNUC13530 zone)

HOVERGEN: ICK_RAT

ID   ICK_RAT                 Reviewed;         629 AA.
AC   Q62726;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   13-OCT-2009, entry version 67.
DE   RecName: Full=Serine/threonine-protein kinase ICK;
DE            EC=2.7.11.22;
DE   AltName: Full=Intestinal cell kinase;
DE   AltName: Full=MAK-related kinase;
DE            Short=MRK;
GN   Name=Ick;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND AUTOPHOSPHORYLATION.
RC   TISSUE=Heart;
RX   MEDLINE=96112619; PubMed=8570168;
RA   Abe S., Yagi T., Ishiyama S., Hiroe M., Marumo F., Ikawa Y.;
RT   "Molecular cloning of a novel serine/threonine kinase, MRK, possibly
RT   involved in cardiac development.";
RL   Oncogene 11:2187-2195(1995).
CC   -!- FUNCTION: May play a role in cardiac development.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- COFACTOR: Magnesium.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Expressed in embryonic heart from day 11.
CC       Highly expressed in the uterus and at lower levels in brain,
CC       heart, lung, kidney, skeletal muscle, ovary and liver in adult
CC       tissues.
CC   -!- PTM: Autophosphorylated on serine and threonine residues. May play
CC       a role in enzyme activation.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
CC       Ser/Thr protein kinase family. CDC2/CDKX subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
CC   -!- GENE_FAMILY: HBG014652 [ FAMILY / ALN / TREE ]
DR   EMBL; D26178; BAA05166.1; -; mRNA.
DR   IPI; IPI00326779; -.
DR   RefSeq; NP_620241.1; -.
DR   UniGene; Rn.3750; -.
DR   HSSP; P24941; 1H06.
DR   STRING; Q62726; -.
DR   PhosphoSite; Q62726; -.
DR   Ensembl; ENSRNOT00000012257; ENSRNOP00000012257; ENSRNOG00000008691; Rattus norvegicus.
DR   GeneID; 84411; -.
DR   KEGG; rno:84411; -.
DR   UCSC; NM_138886; rat.
DR   CTD; 84411; -.
DR   RGD; 71050; Ick.
DR   HOVERGEN; Q62726; -.
DR   BRENDA; 2.7.11.22; 248.
DR   NextBio; 616888; -.
DR   ArrayExpress; Q62726; -.
DR   Genevestigator; Q62726; -.
DR   GermOnline; ENSRNOG00000008691; Rattus norvegicus.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IDA:UniProtKB.
DR   GO; GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IDA:UniProtKB.
DR   GO; GO:0007243; P:protein kinase cascade; IDA:UniProtKB.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q62726.
DR   SWISS-2DPAGE; Q62726.
KW   ATP-binding; Cytoplasm; Developmental protein; Kinase; Magnesium;
KW   Metal-binding; Nucleotide-binding; Phosphoprotein;
KW   Serine/threonine-protein kinase; Transferase.
FT   DOMAIN        7    209       PRODOM:2005.1:PD000001  8496
FT   DOMAIN      243    285       PRODOM:2005.1:PD904265  25
FT   DOMAIN      287    629       PRODOM:2005.1:PD432898  3
FT   CHAIN         1    629       Serine/threonine-protein kinase ICK.
FT                                /FTId=PRO_0000086009.
FT   DOMAIN        4    284       Protein kinase.
FT   NP_BIND      10     18       ATP (By similarity).
FT   ACT_SITE    125    125       Proton acceptor (By similarity).
FT   BINDING      33     33       ATP (By similarity).
FT   MOD_RES      14     14       Phosphothreonine (By similarity).
FT   MOD_RES      15     15       Phosphotyrosine (By similarity).
FT   MOD_RES     156    156       Phosphotyrosine (By similarity).
FT   MOD_RES     157    157       Phosphothreonine (By similarity).
FT   MOD_RES     159    159       Phosphotyrosine (By similarity).
SQ   SEQUENCE   629 AA;  70569 MW;  AA4143D73F891E8B CRC64;
     MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA
     NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG
     FFHRDLKPEN LLCMGPELVK IADFGLAREI RSRPPYTDYV STRWYRAPEV LLRSTNYSSP
     IDVWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFIWPQ
     CIPNNLKTLI PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GISTQDSGKP
     QKDVQDKTGP PPYVKPAPPA QAPTKAHTLI SSRPNQASQP HQHFVYPYKG EASRTEQLSH
     VQEGQPNPPF FPSLHNKNLP PKILAGLEQK SGDMKPKSRR RWGLISRSTK GSDDWADLAD
     LDFSSSLTRI DVKNKKRQSD DPLCRFESVL DLKPSEPVGT GTSVSTQASS QRRDTPTLQS
     TAKQHYLKHS RYLPGINIRN GVLPNPGKDF LPSSSWSSSG LSGKSSGTVS VVSKITSVGS
     GSTSSTGLTG SYIPSFLKKE VGSVMQRVQL APLAAPSPGY SSLKAVRPHP GRPFFHTQPR
     STPGLIPRPP AVQPVHGRID WSSKYPSRR
//

If you have problems or comments...

PBIL Back to PBIL home page