(data stored in ACNUC7421 zone)

HOGENOM: IDLOI1_1_PE1004

ID   IDLOI1_1_PE1004                      STANDARD;      PRT;   286 AA.
AC   IDLOI1_1_PE1004; Q5QWH6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Bifunctional protein FolD;Includes: RecName:
DE   Full=Methylenetetrahydrofolate dehydrogenase; EC=1.5.1.5;Includes:
DE   RecName: Full=Methenyltetrahydrofolate cyclohydrolase; EC=3.5.4 9;
DE   (IDLOI1_1.PE1004).
GN   Name=folD; OrderedLocusNames=IL1008;
OS   IDIOMARINA LOIHIENSIS L2TR.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Idiomarinaceae; Idiomarina.
OX   NCBI_TaxID=283942;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS IDLOI1_1.PE1004.
CC       Idiomarina loihiensis L2TR chromosome, complete genome.
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:FOLD_IDILO
CC   -!- FUNCTION: Catalyzes the oxidation of 5,10-
CC       methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and
CC       then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-
CC       formyltetrahydrofolate (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + NADP(+) =
CC       5,10-methenyltetrahydrofolate + NADPH.
CC   -!- CATALYTIC ACTIVITY: 5,10-methenyltetrahydrofolate + H(2)O = 10-
CC       formyltetrahydrofolate.
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the tetrahydrofolate
CC       dehydrogenase/cyclohydrolase family.
CC   -!- GENE_FAMILY: HOG000218242 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q5QWH6; -.
DR   EMBL; AE017340; AAV81848.1; -; Genomic_DNA.
DR   RefSeq; YP_155397.1; NC_006512.1.
DR   HSSP; P24186; 1B0A.
DR   ProteinModelPortal; Q5QWH6; -.
DR   SMR; Q5QWH6; 3-284.
DR   GeneID; 3173574; -.
DR   GenomeReviews; AE017340_GR; IL1008.
DR   KEGG; ilo:IL1008; -.
DR   NMPDR; fig|283942.3.peg.367; -.
DR   OMA; FANAKEV; -.
DR   BioCyc; ILOI283942:IL1008-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.
DR   GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_01576; THF_DHG_CYH; 1; -.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   PROSITE; PS00766; THF_DHG_CYH_1; FALSE_NEG.
DR   PROSITE; PS00767; THF_DHG_CYH_2; 1.
DR   HOGENOMDNA; IDLOI1_1.PE1004; -.
KW   5,10-methylene-tetrahydrofolate dehydrogenase;
KW   Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis;
KW   Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP;
KW   One-carbon metabolism; Oxidoreductase; Purine biosynthesis.
SQ   SEQUENCE   286 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPAQIIDGKT IAATVRQAVK QQVKERIDSG LRAPGLAVVL VGSDAASEVY VGNKRRACED
     VGFRSFDYDL PITTTQKELE KLIEELNDDD AVDGILVQLP LPAGLDATPI LERIRPDKDV
     DGFHPFNIGR LSQRIPALRP CTPKGIMTLL EHTHVDLHGL NAVVVGASNI VGRPMSLELL
     LAGATTTVCH RFTKDLSDHV KRADIVVVAV GKAEFIPGEW IKPGAIVIDV GMNRLPDGRL
     TGDVEFSVAA ERAGWITPVP GGVGPMTVAS LIENTLQACV DYHDVR
//

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