(data stored in SCRATCH3701 zone)

HOGENOM6: KLEP3_3_PE1479

ID   KLEP3_3_PE1479                       STANDARD;      PRT;   877 AA.
AC   KLEP3_3_PE1479; B5XNZ4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (KLEP3_3.PE1479).
GN   Name=gyrA; OrderedLocusNames=KPK_1511;
OS   KLEBSIELLA PNEUMONIAE 342.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=507522;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS KLEP3_3.PE1479.
CC       Klebsiella pneumoniae 342, complete genome.
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:B5XNZ4_KLEP3
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B5XNZ4; -.
DR   EMBL; CP000964; ACI09783.1; -; Genomic_DNA.
DR   RefSeq; YP_002237364.1; NC_011283.1.
DR   STRING; B5XNZ4; -.
DR   GeneID; 6934689; -.
DR   GenomeReviews; CP000964_GR; KPK_1511.
DR   KEGG; kpe:KPK_1511; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; KLEP3_3.PE1479; -.
DR   PRODOM; KLEP3_3_PE1479.
DR   SWISS-2DPAGE; KLEP3_3_PE1479.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   877 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSDLAREITP VNIEEELKNS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMNVLGNDWN
     KAYKKSARVV GDVIGKYHPH GDSAVYDTIV RMAQPFSLRY MLVDGQGNFG SIDGDSAAAM
     RYTEIRLAKI AHELMADLEK ETVDFVDNYD GTERIPDVMP TKIPNLLVNG ASGIAVGMAT
     NIPPHNLTEV INGCLAYVDD EDISIEGLMA HIPGPDFPTA AIINGRRGIE EAYRTGRGKV
     YIRARAEVEV DAKSGRETII VHEIPYQVNK ARLIEKIAEL VKEKRVEGIS ALRDESDKDG
     MRIVIEVKRD AVGEVVLNNL YSQTQLQVSF GINMVALHHG QPKIMNLKDI IAAFVRHRRE
     VVTRRTIFEL RKARDRAHIL EALAVALANI DPIIELIRRA PTPAEAKTAL VAQAWDLGNV
     AAMLERAGDD AARPEWLEPE FGVRDGKYYL TEQQAQAILD LRLQKLTGLE HEKLLDEYKE
     LLEQIAELLH ILGSADRLME VIREELELIR DQFGDERRTE ITANSADINI EDLINQEDVV
     VTLSHQGYVK YQPLTDYEAQ RRGGKGKSAA RIKEEDFIDR LLVANTHDTI LCFSSRGRLY
     WMKVYQLPEA SRGARGRPIV NLLPLEADER ITAILPVREY EEGVNVFMAT ASGTVKKTAL
     TEFSRPRSAG IIAVNLNEGD ELIGVDLTSG QDEVMLFSAA GKVVRFKEDA VRAMGRTATG
     VRGIKLAEND SVVSLIIPRG EGAILTVTQN GYGKRTAAAE YPTKSRATQG VISIKVTERN
     GSVVGAVQVD DCDQIMMITD AGTLVRTRVS EVSIVGRNTQ GVILIRTAED ENVVGLQRVA
     EPVDDEELDA IDGSVAEGDD DIAPEADTDD DIAEDEE
//

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