(data stored in ACNUC7421 zone)

HOGENOM: KLLAC1_2_PE375

ID   KLLAC1_2_PE375                       STANDARD;      PRT;   899 AA.
AC   KLLAC1_2_PE375; P49380;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Plasma membrane ATPase; EC=3.6.3 6;AltName: Full=Proton
DE   pump; (KLLAC1_2.PE375).
GN   Name=PMA1; OrderedLocusNames=KLLA0A09031g;
OS   KLUYVEROMYCES LACTIS NRRL Y-1140.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS KLLAC1_2.PE375.
CC       Kluyveromyces lactis (strain CBS 2359 / WM37 / ATCC 8585 / DSM 70799 /
CC       NRRL Y-1140) chromosome A, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:PMA1_KLULA
CC   -!- FUNCTION: The plasma membrane ATPase of plants and fungi is a
CC       hydrogen ion pump. The proton gradient it generates drives the
CC       active transport of nutrients by H(+)-symport. The resulting
CC       external acidification and/or internal alkinization may mediate
CC       growth responses.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate +
CC       H(+)(Out).
CC   -!- ENZYME REGULATION: Activated by high pH or also by potassium ions
CC       when the medium pH is low.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type)
CC       (TC 3.A.3) family. Type IIIA subfamily.
CC   -!- GENE_FAMILY: HOG000160005 [ FAMILY / ALN / TREE ]
DR   EMBL; AAA69688.1; - ;
DR   UniProtKB/Swiss-Prot; P49380; -.
DR   EMBL; L37875; AAA69688.1; -; Genomic_DNA.
DR   EMBL; CR382121; CAH02983.1; -; Genomic_DNA.
DR   RefSeq; XP_451395.1; XM_451395.1.
DR   ProteinModelPortal; P49380; -.
DR   SMR; P49380; 28-897.
DR   STRING; P49380; -.
DR   GeneID; 2896449; -.
DR   GenomeReviews; CR382121_GR; KLLA0A09031g.
DR   KEGG; kla:KLLA0A09031g; -.
DR   eggNOG; fuNOG06156; -.
DR   OMA; TQHEKEN; -.
DR   OrthoDB; EOG4M68RQ; -.
DR   PhylomeDB; P49380; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008250; ATPase_P-typ_ATPase-assoc-dom.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023300; ATPase_P-typ_cyto_domA.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_domN.
DR   InterPro; IPR000695; ATPase_P-typ_H-transp.
DR   InterPro; IPR001757; ATPase_P-typ_ion-transptr.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR006534; ATPase_P-typ_PM_proton-efflux.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom.
DR   InterPro; IPR005834; Dehalogen-like_hydro.
DR   InterPro; IPR023214; HAD-like_dom.
DR   Gene3D; G3DSA:2.70.150.10; ATPase_P-typ_cyto_domA; 2.
DR   Gene3D; G3DSA:3.40.1110.10; ATPase_P-typ_cyto_domN; 2.
DR   Gene3D; G3DSA:1.20.1110.10; ATPase_P-typ_TM_dom; 2.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00120; HATPASE.
DR   SMART; SM00831; Cation_ATPase_N; 1.
DR   SUPFAM; SSF56784; HAD-like_dom; 1.
DR   TIGRFAMs; TIGR01647; ATPase-IIIA_H; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 3.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   HOGENOMDNA; KLLAC1_2.PE375; -.
KW   CAH02983.1824841755old_1320000031; AAA69688.1;
KW   Plasma membrane ATPase ;
KW   ATP-binding; Cell membrane; Complete proteome; Hydrogen ion transport;
KW   Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding;
KW   Nucleotide-binding; Phosphoprotein; Transmembrane;
KW   Transmembrane helix; Transport.
SQ   SEQUENCE   899 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSAATEPTKE KPVNNQDSDD EDEDIDQLIE DLQSHHGLDD ESEDDEHVAA GSARPVPEEL
     LQTDPSYGLT SDEVTKRRKK YGLNQMSEET ENLFVKFLMF FIGPIQFVME AAAILAAGLE
     DWVDFGVICG LLFLNAAVGF IQEYQAGSIV DELKKTLANS AVVIRDGNLV EVPSNEVVPG
     DILQLEDGVV IPADGRLVTE DCFIQIDQSA ITGESLAVDK RFGDSTFSSS TVKRGEAFMI
     VTATGDSTFV GRAAALVNKA AAGSGHFTEV LNGIGTILLI LVIVTLLLVW VASFYRTNKI
     VRILRYTLAI TIVGVPVGLP AVVTTTMAVG AAYLAKKQAI VQKLSAIESL AGVEILCSDK
     TGTLTKNKLS LHEPYTVEGV DPDDLMLTAC LAASRKKKGL DAIDKAFLKS LISYPRAKAA
     LTKYKLLEFH PFDPVSKKVT AIVESPEGER IICVKGAPLF VLKTVEEEHP IPEDVRENYE
     NKVAELASRG FRALGVARKR GEGHWEILGV MPCMDPPRDD TAQTVNEARH LGLRVKMLTG
     DAVGIAKETC RQLGLGTNIY NAERLGLGGG GDMPGSELAD FVENADGFAE VFPQHKYNVV
     EILQQRGYLV AMTGDGVNDA PSLKKADTGI AVEGATDAAR SAADIVFLAP GLSAIIDALK
     TSRQIFHRMY SYVVYRIALS LHLEIFLGLW IAILNRSLNI DLVVFIAIFA DVATLAIAYD
     NAPYSPKPVK WNLRRLWGMS VILGIILAIG TWITLTTMFV PKGGIIQNFG SIDGVLFLQI
     SLTENWLIFI TRAAGPFWSS IPSWQLSGAV LIVDIIATMF CLFGWWSQNW NDIVTVVRVW
     IFSFGVFCVM GGAYYMMSES EAFDRFMNGK SRRDKPSGRS VEDFLMAMQR VSTQHEKEN
//

If you have problems or comments...

PBIL Back to PBIL home page