(data stored in ACNUC7421 zone)

HOGENOM: KLLAC1_5_PE643

ID   KLLAC1_5_PE643                       STANDARD;      PRT;   407 AA.
AC   KLLAC1_5_PE643; Q6CQP3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (KLLAC1_5.PE643).
GN   Name=MRI1; OrderedLocusNames=KLLA0D15455g;
OS   KLUYVEROMYCES LACTIS NRRL Y-1140.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS KLLAC1_5.PE643.
CC       Kluyveromyces lactis (strain CBS 2359 / WM37 / ATCC 8585 / DSM 70799 /
CC       NRRL Y-1140) chromosome D, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:MTNA_KLULA
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q6CQP3; -.
DR   EMBL; CR382124; CAH00842.1; -; Genomic_DNA.
DR   RefSeq; XP_453746.1; XM_453746.1.
DR   ProteinModelPortal; Q6CQP3; -.
DR   SMR; Q6CQP3; 1-201, 218-406.
DR   STRING; Q6CQP3; -.
DR   GeneID; 2893603; -.
DR   GenomeReviews; CR382124_GR; KLLA0D15455g.
DR   KEGG; kla:KLLA0D15455g; -.
DR   eggNOG; fuNOG06631; -.
DR   OMA; EDGWKVI; -.
DR   OrthoDB; EOG4S1XGM; -.
DR   PhylomeDB; Q6CQP3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; KLLAC1_5.PE643; -.
KW   CAH00842.1824841755old_1320000031;
KW   Methylthioribose-1-phosphate isomerase ;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; Isomerase;
KW   Methionine biosynthesis; Nucleus.
SQ   SEQUENCE   407 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSLKAIVFDR VLGKCSVKIL DQLLLPYQTQ YLTINTIDDG YRSIKSMQVR GAPAIAIVGV
     LSTLMECQLL LQESFVKTQS FYDLTQLEKI LNERLDLLLS SRPTAVNLSN AITDLRKLIS
     NDIGKTYNSL FQYACDIIDH DYADNFTMGE NGAKHLLAQL EKEAFEGDFG VLTICNTGSL
     ATSGYGTALG VIRSLYERTK KQISGDEQPK RTKTSNAKMV RVFPLETRPY NQGSRLTAYE
     LLHDEIPSTL ITDSSISYLV STSKIPIKAA FVGADRIVKN GDTANKIGTY QLSIVCRHFG
     IKFYVVAPTT TFDSNTETGD KIVVEERPPN EFRFVQGTLI DGTDPTPVLN ESKTPVKAKV
     GITPLDMPVW NPSFDITPYT HIDGIITEKG VFAKDENGNF HLETAFQ
//

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