(data stored in ACNUC16935 zone)

HOGENOM: KLLAC1_6_PE26

ID   KLLAC1_6_PE26                        STANDARD;      PRT;   381 AA.
AC   KLLAC1_6_PE26; P0CG75; Q6CQ09; Q6CQB8; Q9Y848; Q9Y852;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Polyubiquitin;Contains: RecName: Full=Ubiquitin;Flags:
DE   Precursor; (KLLAC1_6.PE26).
GN   Name=ubi4; OrderedLocusNames=KLLA0E00682g;
OS   KLUYVEROMYCES LACTIS NRRL Y-1140.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS KLLAC1_6.PE26.
CC       Kluyveromyces lactis (strain CBS 2359 / WM37 / ATCC 8585 / DSM 70799 /
CC       NRRL Y-1140) chromosome E, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:UBI4P_KLULA
CC   -!- FUNCTION: Ubiquitin exists either covalently attached to another
CC       protein, or free (unanchored). When covalently bound, it is
CC       conjugated to target proteins via an isopeptide bond either as a
CC       monomer (monoubiquitin), a polymer linked via different Lys
CC       residues of the ubiquitin (polyubiquitin chains) or a linear
CC       polymer linked via the initiator Met of the ubiquitin (linear
CC       polyubiquitin chains). Polyubiquitin chains, when attached to a
CC       target protein, have different functions depending on the Lys
CC       residue of the ubiquitin that is linked: Lys-6-linked may be
CC       involved in DNA repair; Lys-11-linked is involved in ERAD
CC       (endoplasmic reticulum-associated degradation) and in cell-cycle
CC       regulation; Lys-29-linked is involved in lysosomal degradation;
CC       Lys-33-linked is involved in kinase modification; Lys-48-linked is
CC       involved in protein degradation via the proteasome; Lys-63-linked
CC       is involved in endocytosis, and DNA-damage responses. Linear
CC       polymer chains formed via attachment by the initiator Met lead to
CC       cell signaling. Ubiquitin is usually conjugated to Lys residues of
CC       target proteins, however, in rare cases, conjugation to Cys or Ser
CC       residues has been observed. When polyubiquitin is free
CC       (unanchored-polyubiquitin), it also has distinct roles, such as in
CC       activation of protein kinases, and in signaling (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- MISCELLANEOUS: For a better understanding, features related to
CC       ubiquitin are only indicated for the first chain.
CC   -!- MISCELLANEOUS: Ubiquitin is encoded by several different genes.
CC       Ubi3 genes code for a single copy of ubiquitin fused to the
CC       ribosomal proteins S27a. Ubi4 is synthesized as a polyubiquitin
CC       precursor with 5 exact head to tail repeats.
CC   -!- SIMILARITY: Belongs to the ubiquitin family.
CC   -!- SIMILARITY: Contains 5 ubiquitin-like domains.
CC   -!- GENE_FAMILY: HOG000233942 [ FAMILY / ALN / TREE ]
DR   EMBL; CAB50898.1; - ;
DR   UniProtKB/Swiss-Prot; P0CG75; Q6CQ09; Q6CQB8; Q9Y848; Q9Y852; -.
DR   EMBL; AJ243800; CAB50898.1; -; Genomic_DNA.
DR   EMBL; CR382125; CAG99067.1; -; Genomic_DNA.
DR   PIR; T45526; T45526.
DR   RefSeq; XP_453980.1; XM_453980.1.
DR   ProteinModelPortal; P0CG75; -.
DR   GeneID; 2893864; -.
DR   GenomeReviews; CR382125_GR; KLLA0E00682g.
DR   KEGG; kla:KLLA0E00749g; -.
DR   OMA; IQKESTH; -.
DR   OrthoDB; EOG4Z0FDT; -.
DR   PhylomeDB; Q9Y848; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR019956; Ubiquitin_subgr.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   Pfam; PF00240; ubiquitin; 5.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 5.
DR   PROSITE; PS00299; UBIQUITIN_1; 5.
DR   PROSITE; PS50053; UBIQUITIN_2; 5.
DR   HOGENOMDNA; KLLAC1_6.PE26; -.
KW   CAG99067.1824841755old_1320000031; CAB50898.1;
KW   Polyubiquitin;
KW   Complete proteome; Cytoplasm; Isopeptide bond; Nucleus; Repeat;
KW   Ubl conjugation.
SQ   SEQUENCE   381 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQIFVKTLTG KTITLEVESS DTIDNVKSKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
     IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVESSDTID NVKSKIQDKE GIPPDQQRLI
     FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE SSDTIDNVKS
     KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT
     ITLEVESSDT IDNVKSKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR
     LRGGMQIFVK TLTGKTITLE VESSDTIDNV KSKIQDKEGI PPDQQRLIFA GKQLEDGRTL
     SDYNIQKEST LHLVLRLRGG I
//

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