(data stored in ACNUC7421 zone)

HOGENOM: KLLAC1_6_PE748

ID   KLLAC1_6_PE748                       STANDARD;      PRT;   754 AA.
AC   KLLAC1_6_PE748; P49381;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Neutral trehalase; EC=3.2.1 28;AltName:
DE   Full=Alpha,alpha-trehalase;AltName: Full=Alpha,alpha-trehalose
DE   glucohydrolase; (KLLAC1_6.PE748).
GN   Name=NTH1; OrderedLocusNames=KLLA0E17325g;
OS   KLUYVEROMYCES LACTIS NRRL Y-1140.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS KLLAC1_6.PE748.
CC       Kluyveromyces lactis (strain CBS 2359 / WM37 / ATCC 8585 / DSM 70799 /
CC       NRRL Y-1140) chromosome E, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:TREA_KLULA
CC   -!- CATALYTIC ACTIVITY: Alpha,alpha-trehalose + H(2)O = 2 D-glucose.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC   -!- GENE_FAMILY: HOG000192885 [ FAMILY / ALN / TREE ]
DR   EMBL; CAA57181.1; - ;
DR   UniProtKB/Swiss-Prot; P49381; -.
DR   EMBL; X81421; CAA57181.1; -; Genomic_DNA.
DR   EMBL; CR382125; CAG99815.1; -; Genomic_DNA.
DR   RefSeq; XP_454728.1; XM_454728.1.
DR   ProteinModelPortal; P49381; -.
DR   STRING; P49381; -.
DR   CAZy; GH37; Glycoside Hydrolase Family 37.
DR   GeneID; 2894277; -.
DR   GenomeReviews; CR382125_GR; KLLA0E17325g.
DR   KEGG; kla:KLLA0E17271g; -.
DR   eggNOG; fuNOG05742; -.
DR   OMA; RQWDYPY; -.
DR   OrthoDB; EOG4WQ49Q; -.
DR   PhylomeDB; P49381; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:EC.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005993; P:trehalose catabolic process; IEA:InterPro.
DR   InterPro; IPR008928; 6-hairpin_glycosidase-like.
DR   InterPro; IPR001661; Glyco_hydro_37.
DR   InterPro; IPR018232; Glyco_hydro_37_CS.
DR   InterPro; IPR011120; Trehalase_Ca-bd.
DR   PANTHER; PTHR23403; Glyco_hydro_37; 1.
DR   Pfam; PF01204; Trehalase; 1.
DR   Pfam; PF07492; Trehalase_Ca-bi; 1.
DR   PRINTS; PR00744; GLHYDRLASE37.
DR   SUPFAM; SSF48208; Glyco_trans_6hp; 1.
DR   PROSITE; PS00927; TREHALASE_1; 1.
DR   PROSITE; PS00928; TREHALASE_2; 1.
DR   HOGENOMDNA; KLLAC1_6.PE748; -.
KW   CAG99815.1824841755old_1320000031; CAA57181.1;
KW   Neutral trehalase;
KW   Complete proteome; Cytoplasm; Glycosidase; Hydrolase.
SQ   SEQUENCE   754 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDGKVNNNPP RSRHRRTSSL EEVVDPFSTP DVYYGPKSDP SKLLSKNRFT RTRTFSVAEP
     GGGKGHSSSY TSPYFDTTVP LRRRGSEDDS YSASQGQRRF YIEDVDKTLK ELLASEDTDG
     NYQITIEDTG PKVIRVGTVN SNGYKHVHIR GTYMLSNLLQ ELTLAKLFNR KQVILDEARL
     NENPVNRMTR LISGQFWKSL TRRIDSNNIA KIAYDTKIDT PKAKNPRIYV PYNCQDEYQQ
     LVQWSEMDPS LQLEVNYLPK DITPEFVKSL NDKPGLLCLA MESHMDPVTG EETWVGFPYA
     VPGGRFNELY GWDSYFMALG LLESNKLDVA RGMVEHFIFE IDHYGKILNA NRSYYLCRSQ
     PPFLTDMALQ VCRKMGGDKN PVAVDLLRRA FKAAIKEYLT VWTASPRLDE KTGLSCYHPD
     GIGIPPETEP GHFDSILRKY AEKYNVSIPE FRDLYNSQKV HEPDLDVFFL HDRGVRESGH
     DTTYRFENVC AYLATIDLNS LLYKYEVDIA YVIKKYFGDN FEGLPEGHRT SNDWEKLAEV
     RKERIDKYLW DEETGFYYDY NVKTEKRTSY ESVTTFWALW AGMSSQEQAQ RMVENALPKL
     EEFGGLVACT ARSRGELSLD RPTRQWDYPF GWAPHQILVW DGLVRYGYEN HTRRLAYRWL
     FLMTKAFVDY NGIVVEKYDV TRGTDPHRVD AEYGNQGADF KGVATEGFGW VNSSYLLGMK
     YMNNFARRAL GTCVTPKVFF GRLPPKEKKK YGLE
//

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