(data stored in SCRATCH3701 zone)

HOGENOM6: LAACI1_1_PE6

ID   LAACI1_1_PE6                         STANDARD;      PRT;   824 AA.
AC   LAACI1_1_PE6; Q5FN10;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; EC=5.99.1 3; (LAACI1_1.PE6).
GN   Name=gyrA; OrderedLocusNames=LBA0006;
OS   LACTOBACILLUS ACIDOPHILUS NCFM.
OC   Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LAACI1_1.PE6.
CC       Lactobacillus acidophilus NCFM chromosome, complete genome.
CC       NRRL Y-1140) chromosome F, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:Q5FN10_LACAC
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q5FN10; -.
DR   EMBL; CP000033; AAV41914.1; -; Genomic_DNA.
DR   RefSeq; YP_192945.1; NC_006814.3.
DR   ProteinModelPortal; Q5FN10; -.
DR   SMR; Q5FN10; 33-490.
DR   GeneID; 3252401; -.
DR   GenomeReviews; CP000033_GR; LBA0006.
DR   KEGG; lac:LBA0006; -.
DR   NMPDR; fig|272621.3.peg.488; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; LAACI1_1.PE6; -.
DR   PRODOM; LAACI1_1_PE6.
DR   SWISS-2DPAGE; LAACI1_1_PE6.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   824 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDENQTQDHR IRNVDLTGMM RSSFLDYAMS VIVARALPDV RDGLKPVQRR ILYGMSELGV
     TPDKPYKKSA RIVGEVMGKF HPHGDSSIYL AMAHMAQDFS YRYMLVDGHG NFGSVDGDEP
     AAMRYTEARM SKIAVEMLRD INKNTIDWQR NYDDTESEPV VLPARIPNLL VNGANGIAVG
     MTTNIPPHNL SEVISGLHML MRNPDATTKD LMKEIPGPDF PTGGIIMGRG GIYRAYESGK
     GNIVVRAKTN IETEKSGRER IIVSEIPFMV NKAELVKKIA DLAREKVIDG ITGVRDESDQ
     TGMRITIDIR RDASASVVLN NLFKQTQMQA NFGMNMVAIV DGAPHYLTLK QMLQYYLDHQ
     EDVVTRRTKF ELAKAEARAH ILEGLRIALD NIDEIVHIIR SSHSSDIAKA TLISRFGLDD
     KQSQAILDMR LVRLTGLERD KVEAEYQELQ AKIADYKDIL AKPERIDQII YDELLDIQKR
     FGDERRTEIG ASEVVSIEDE DLIEKQNILL TVTHNGYIKR MPIQEFKTQN RGGKGIKGMG
     VQDGDFIEHL IYSSTHDMLL FFTNAGKVYS KKAYEIPEYG RMAKGLPIVN LLQLEKGEKV
     QAVVNIPEGA DDNYLFFVTK MGTVKRTHVS EFANIRNSGL IALTLRDGDE LSNVLTTDGN
     QNILIGTHLG YAVTFNESDV RAMGRTAAGV RGINLRPEDY VVGSGVLGAN DQVLVISEKG
     YGKRTPASEY PVKGRGGKGI KTANITEKNG PLAGVIVLDS DEDIMVITTD GIMIRFKTAD
     VSQTSRSTIG VRLIKVNDDS RVASLTIVPT EAEQDEIGDE DSEK
//

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