(data stored in ACNUC17686 zone)

HOGENOM: LACC3_2_PE1662

ID   LACC3_2_PE1662                       STANDARD;      PRT;   201 AA.
AC   LACC3_2_PE1662; Q037U3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Thiamine transporter ThiT;AltName: Full=Thiamine ECF
DE   transporter S component ThiT; (LACC3_2.PE1662).
GN   Name=thiT; OrderedLocusNames=LSEI_1757;
OS   LACTOBACILLUS CASEI ATCC 334.
OC   Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
OX   NCBI_TaxID=321967;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LACC3_2.PE1662.
CC       Lactobacillus casei ATCC 334, complete genome.
CC       NRRL Y-1140) chromosome F, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:THIT_LACC3
CC   -!- FUNCTION: Thiamine-binding protein that interacts with the energy-
CC       coupling factor (ECF) ABC-transporter complex. Unlike classic ABC
CC       transporters this ECF transporter provides the energy necessary to
CC       transport a number of different substrates. The substrates
CC       themselves are bound by transmembrane, not extracytoplasmic
CC       soluble proteins and transport it into cells. Binds thiamine with
CC       a dissociation constant of 0.5 nM. Upon coexpression with its
CC       energy-coupling factor (ECF) ABC-transporter complex EcfA1A2T in
CC       Lactococcus lactis subsp. cremoris (strain NZ9000) allows thiamine
CC       uptake; uptake requires both ThiT and EcfA1A2T.
CC   -!- SUBUNIT: In Lactococcus lactis subsp. cremoris (strain NZ9000)
CC       forms a stable energy-coupling factor (ECF) transporter complex
CC       probably composed of a membrane-embedded substrate-binding protein
CC       (S component), two ATP-binding proteins (A components) and a
CC       transmembrane protein (T component).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the ECF family. Thiamine transporter
CC       (TC 2.A.88) subfamily.
CC   -!- GENE_FAMILY: HOG000013022 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q037U3; -.
DR   EMBL; CP000423; ABJ70529.1; -; Genomic_DNA.
DR   RefSeq; YP_806971.1; NC_008526.1.
DR   STRING; Q037U3; -.
DR   GeneID; 4420237; -.
DR   GenomeReviews; CP000423_GR; LSEI_1757.
DR   KEGG; lca:LSEI_1757; -.
DR   eggNOG; COG3859; -.
DR   OMA; WYSFTVN; -.
DR   ProtClustDB; CLSK770886; -.
DR   BioCyc; LCAS321967:LSEI_1757-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR012651; Thia_Transptr_ThiT/YuaJ.
DR   Pfam; PF09515; Thia_YuaJ; 1.
DR   TIGRFAMs; TIGR02357; Thia_yuaJ; 1.
DR   HOGENOMDNA; LACC3_2.PE1662; -.
KW   hypothetical protein;
KW   Cell membrane; Complete proteome; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
SQ   SEQUENCE   201 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQQHKQLVVI LETAIIAAFA MALTYIPHTT GVSAIELNYG LIPIAVLAMR RGLVPAAWAG
     FVWGILDLIL RGIGGGSVLN PLQGILEYPI AFTLVGLMGL TFASFQKAVR GSEKVKASGY
     AFAGIIIGTF AKYFIHFIAG VVFWGAYAPK GTNVWVYSLI VNGGSALFST VLTIVVVGVL
     LTVAPQLFVA KDGKSFSTKA A
//

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