(data stored in ACNUC7421 zone)

HOGENOM: LACCB_1_PE1010

ID   LACCB_1_PE1010                       STANDARD;      PRT;   963 AA.
AC   LACCB_1_PE1010; B3WCQ6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=Excinuclease ABC, subunit A; (LACCB_1.PE1010).
GN   Name=uvrA1; OrderedLocusNames=LCABL_10710;
OS   LACTOBACILLUS CASEI BL23.
OC   Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
OX   NCBI_TaxID=543734;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LACCB_1.PE1010.
CC       Lactobacillus casei BL23 chromosome, complete genome.
CC       NRRL Y-1140) chromosome F, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:B3WCQ6_LACCB
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding
CC       protein. A damage recognition complex composed of 2 UvrA and 2
CC       UvrB subunits scans DNA for abnormalities. When the presence of a
CC       lesion has been verified by UvrB, the UvrA molecules dissociate
CC       (By similarity).
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC   -!- GENE_FAMILY: HOG000050449 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B3WCQ6; -.
DR   EMBL; FM177140; CAQ66157.1; -; Genomic_DNA.
DR   RefSeq; YP_001987015.1; NC_010999.1.
DR   STRING; B3WCQ6; -.
DR   GeneID; 6407026; -.
DR   GenomeReviews; FM177140_GR; LCABL_10710.
DR   KEGG; lcb:LCABL_10710; -.
DR   OMA; GAIKGWD; -.
DR   ProtClustDB; CLSK2317840; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:HAMAP.
DR   HAMAP; MF_00205; UvrA; 1; -.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR003593; ATPase_AAA+_core.
DR   InterPro; IPR004602; UvrA_ABC.
DR   Gene3D; G3DSA:3.30.1490.20; ATP_grasp_subdomain_1; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 1.
DR   TIGRFAMs; TIGR00630; Uvra; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   HOGENOMDNA; LACCB_1.PE1010; -.
KW   Excinuclease ABC, subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; DNA-binding; Excision nuclease; Metal-binding;
KW   Nucleotide-binding; Repeat; SOS response; Zinc.
SQ   SEQUENCE   963 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MANDKIVIHG ARAHNLKNID VTIPRNKLVV MTGLSGSGKS SLAFDTLYAE GQRRYVESLS
     AYARQFLGQM EKPDVDSIDG LSPAISIDQK TTSKNPRSTV GTVTEINDYL RLLWARVGHP
     ICPNDGTPIT SQSVEQMVDR VLALPDKTRI QILSPVVRRK KGSHKKVFAK IMREGYVRMR
     VDGEVVDATA DYELDKNKSH DIDIVIDRIV VKPEARSRLF DSFEAALRLS EGYANVDVIG
     GEPLRFSEHF ACPICGFTIG EMEPRLFSFN APFGACPECD GLGVKLTVDM DLVLPEPSMT
     LAEGAIAPWN PISSQYYPEL LAQAAKTFKV RMDVPFNKLT HRERNVVLNG SDGKLFHFHY
     ENDFGGVRDV DVPFEGVLNN ISRRYAETNS DFTRQQMRSY MTALPCPVCH GKRLNRQALA
     VKIEGRDIAE VSDLAIKDAL PFFKTVHLSE AESVIAQPIV KEVVDRLTFL VNVGLGYLTL
     SRSAGTLSGG EAQRIRLATQ IGSNLSGVMY VLDEPSIGLH QRDNDRLIAS LKKMRDLGNT
     LIVVEHDEDT MRAADYLIDV GPGAGEHGGR IMASGTPKQV ARVRKSITGQ YLSGRKFIPV
     PLKRRQGSGK VIRLEGATDH NLKNIDVDFP LGKFIVVSGV SGSGKSTLVN SILRRALAQK
     LNHNSEKPGP YKKILGYKNI EKLINIDQSP IGRTPRSNPA TYTSVFDDIR GLFAETNEAK
     LRGYKKGRFS FNIKGGRCEN CKGDGIIKIE MNFLPDVYVP CEVCHGKRYN SETLEVTYKG
     KNIAEVLDMT VEEATDFFKN IPKIRRKLQT IVDVGLGYVK LGQSATTLSG GEAQRMKLAS
     ELQKLSTGKN FYILDEPTTG LHTDDIKRLL EVLERLVDEG NTVLVIEHNL DVVKTADWVI
     DLGPEGGDGG GQIIATGTPE QVANVADSYT GQYLKPILVR DTQRTKEAAQ TSTKNEVQAV
     SKK
//

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