(data stored in ACNUC7421 zone)

HOGENOM: LACH4_1_PE1

ID   LACH4_1_PE1                          STANDARD;      PRT;   455 AA.
AC   LACH4_1_PE1; A8YW41;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
DE   (LACH4_1.PE1).
GN   Name=dnaA; OrderedLocusNames=lhv_0001;
OS   LACTOBACILLUS HELVETICUS DPC 4571.
OC   Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
OX   NCBI_TaxID=405566;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LACH4_1.PE1.
CC       Lactobacillus helveticus DPC 4571, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:DNAA_LACH4
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC   -!- GENE_FAMILY: HOG000235658 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A8YW41; -.
DR   EMBL; CP000517; ABX26298.1; -; Genomic_DNA.
DR   RefSeq; YP_001576583.1; NC_010080.1.
DR   ProteinModelPortal; A8YW41; -.
DR   STRING; A8YW41; -.
DR   GeneID; 5771350; -.
DR   GenomeReviews; CP000517_GR; lhv_0001.
DR   KEGG; lhe:lhv_0001; -.
DR   OMA; CHTLNAL; -.
DR   ProtClustDB; PRK00149; -.
DR   BioCyc; LHEL405566:LHV_0001-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
DR   GO; GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   HAMAP; MF_00377; DnaA_bact; 1; -.
DR   InterPro; IPR003593; ATPase_AAA+_core.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR013317; DnaA_Hda.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   Gene3D; G3DSA:1.10.1750.10; DnaA_C; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; Trp_repress_rep; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
DR   HOGENOMDNA; LACH4_1.PE1; -.
KW   chromosomal replication initiation protein;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding.
SQ   SEQUENCE   455 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFDIEKFWQH FNDEMRARFN EVAYNAWFKN TKPIFYNKNT HELKILVQNP VAKGYWEKNL
     SSQLIQSAYG YAGIEILPVF QINENNDSPE RIVTPEPRYA IQLQQEKRAH KQFTKNLKLN
     EKYTFDNFVQ GEGNKLAAGA ALAVADSPGS FYNPLFIFGG VGLGKTHLMQ AIGHQMLAER
     PNAKVVYIQS ETFVNDFINS IKNKTQDQFR EKYRTCDLLL VDDIQFFAKK EGIQEEFFHT
     FETLYNDQKQ IVMTSDRLPT EIPDLSERLV SRFTWGLQVE ITPPDLETRI AILRRKAEAE
     GLVIDDNTLD YIASQVDTNI RELEGALVKV QAYATIERAD INVNLAREAL VDLKLVQKNR
     GLQISKIQEV VANYFQTSTA ELKGKKRVRQ IVVPRQIAMY LSRELTDASL PKIGQEFGGK
     DHTTVMHAYD KIDKQIKTDT EIKSAVFDLK QMIEH
//

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