(data stored in ACNUC22050 zone)

HOGENOM: LACTH_1_PE11

ID   LACTH_1_PE11                         STANDARD;      PRT;   334 AA.
AC   LACTH_1_PE11; C5DB85;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=2-dehydropantoate 2-reductase; EC=1.1.1 169;
DE   (LACTH_1.PE11).
GN   OrderedLocusNames=KLTH0A00506g;
OS   LACHANCEA THERMOTOLERANS.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=381046;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LACTH_1.PE11.
CC       Kluyveromyces thermotolerans strain CBS6340 chromosome A complete seque
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:C5DB85_LACTC
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate
CC       into pantoic acid (By similarity).
CC   -!- CATALYTIC ACTIVITY: (R)-pantoate + NADP(+) = 2-dehydropantoate +
CC       NADPH.
CC   -!- PATHWAY: Cofactor biosynthesis; pantothenate biosynthesis;
CC       pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC   -!- GENE_FAMILY: HOG000050225 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C5DB85; -.
DR   EMBL; CU928165; CAR21042.1; -; Genomic_DNA.
DR   RefSeq; XP_002551484.1; XM_002551438.1.
DR   ProteinModelPortal; C5DB85; -.
DR   STRING; C5DB85; -.
DR   GeneID; 8290275; -.
DR   GenomeReviews; CU928165_GR; KLTH0A00506g.
DR   KEGG; lth:KLTH0A00506g; -.
DR   OrthoDB; EOG48SM3M; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR003710; ApbA.
DR   InterPro; IPR013752; ApbA_C.
DR   InterPro; IPR013332; ApbA_N.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR   TIGRFAMs; TIGR00745; ApbA_panE; 1.
DR   HOGENOMDNA; LACTH_1.PE11; -.
KW   CAR21042.1824841755old_1320000031;
KW   KLTH0A00506p;
KW   Complete proteome; NADP; Oxidoreductase; Pantothenate biosynthesis.
SQ   SEQUENCE   334 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPNKPNVLLV GAGGVGAMAS FALEYSGESS VTSVLRSDYA HVVENGFKIN SCDYGRGIRY
     RPSNVVNSIE ASKQYGPFDY VVLATKCIPG VSSMIDIIAP AVSKDTAIVL IQNGIGIEDE
     ALFKCPGNVI LSGVSMIASS NVKGHIEHSD RDFLSVGYFE NVNLTNEHQE KVCKRFVSMY
     KNDKNQCVFD ENVKYSRWRK LVYNACLNPV CALTEADVGR LEIFGGTDSI IRKAMKEVIA
     IAKSDGVELS EALMDFMIRS KDPVYYRPSM LVDIDKGNPL EVEVICGNPV RIAKKNGVEA
     PYLTLIYDLL KVVQGRIMEK RGMLIVPKER QVPK
//

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