(data stored in SCRATCH zone)

HOGENOM: LARHH_1_PE1012

ID   LARHH_1_PE1012                       STANDARD;      PRT;   283 AA.
AC   LARHH_1_PE1012; C1D5X9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Bifunctional protein FolD;Includes: RecName:
DE   Full=Methylenetetrahydrofolate dehydrogenase; EC=1.5.1.5;Includes:
DE   RecName: Full=Methenyltetrahydrofolate cyclohydrolase; EC=3.5.4 9;
DE   (LARHH_1.PE1012).
GN   Name=folD; OrderedLocusNames=LHK_01018;
OS   LARIBACTER HONGKONGENSIS HLHK9.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Laribacter.
OX   NCBI_TaxID=557598;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LARHH_1.PE1012.
CC       Laribacter hongkongensis HLHK9, complete genome.
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:FOLD_LARHH
CC   -!- FUNCTION: Catalyzes the oxidation of 5,10-
CC       methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and
CC       then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-
CC       formyltetrahydrofolate (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + NADP(+) =
CC       5,10-methenyltetrahydrofolate + NADPH.
CC   -!- CATALYTIC ACTIVITY: 5,10-methenyltetrahydrofolate + H(2)O = 10-
CC       formyltetrahydrofolate.
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the tetrahydrofolate
CC       dehydrogenase/cyclohydrolase family.
CC   -!- GENE_FAMILY: HOG000218242 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C1D5X9; -.
DR   EMBL; CP001154; ACO74010.1; -; Genomic_DNA.
DR   RefSeq; YP_002795019.1; NC_012559.1.
DR   STRING; C1D5X9; -.
DR   GeneID; 7756640; -.
DR   GenomeReviews; CP001154_GR; LHK_01018.
DR   KEGG; lhk:LHK_01018; -.
DR   OMA; YSVTHEM; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.
DR   GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_01576; THF_DHG_CYH; 1; -.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   PROSITE; PS00766; THF_DHG_CYH_1; FALSE_NEG.
DR   PROSITE; PS00767; THF_DHG_CYH_2; FALSE_NEG.
DR   HOGENOMDNA; LARHH_1.PE1012; -.
KW   Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis;
KW   Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP;
KW   One-carbon metabolism; Oxidoreductase; Purine biosynthesis.
SQ   SEQUENCE   283 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTAQLIDGKT ISAALLDRVA AGVKARTEAG KRAPALAVIL VGNNPASEVY VRNKKKGCEK
     AGIQSLAYDL PESTSEADLL ALVDELNARS DVDGILVQLP LPRHINPETV IERINPKKDV
     DGFHPYNMGR LAVKMPLLRP CTPRGVMIML EHAGISVEGK HAVVIGQSNI VGRPMALELL
     MERATVTICH SRTRDLPEEV KRADIIVAAV GIPRFVKGDW VKPGAVVIDV GINRLEDGKL
     CGDVDFDAAK EHASWITPVP GGVGLMTVAT LLANTLDAAN LHA
//

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