(data stored in ACNUC7421 zone)

HOGENOM: LEINF1_36_PE72

ID   LEINF1_36_PE72                       STANDARD;      PRT;   375 AA.
AC   LEINF1_36_PE72; A4ICE5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (LEINF1_36.PE72).
GN   ORFNames=LinJ_36_5160, LinJ36.0740;
OS   LEISHMANIA INFANTUM JPCM5.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania.
OX   NCBI_TaxID=435258;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LEINF1_36.PE72.
CC       Leishmania infantum JPCM5 chromosome 36, complete sequence.
CC       complete genome.
CC   -!- ANNOTATIONS ORIGIN:MTNA_LEIIN
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A4ICE5; -.
DR   EMBL; FR796468; CAM72523.1; -; Genomic_DNA.
DR   RefSeq; XP_001469414.1; XM_001469377.1.
DR   ProteinModelPortal; A4ICE5; -.
DR   SMR; A4ICE5; 2-374.
DR   STRING; A4ICE5; -.
DR   GeneID; 5073515; -.
DR   KEGG; lif:LinJ36.0740; -.
DR   eggNOG; KOG1468; -.
DR   OMA; ERVYACE; -.
DR   PhylomeDB; A4ICE5; -.
DR   ProtClustDB; CLSZ2430389; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; LEINF1_36.PE72; -.
KW   translation initiation factor 2 subunit;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; Isomerase;
KW   Methionine biosynthesis; Nucleus; Reference proteome.
SQ   SEQUENCE   375 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MMSKPHHATL ESIKYTPGSL RLLDQRKLPL ETVFDDVLTV EDIWSAINEM RVRGAPAIAV
     SAALGIAVAT QRKVANGELK SGSEVQAFFL SSCDFVMTSR PTAVNLFNCL RDLKEQVEKL
     DPTKAAAEVA QACVELAEAV YTKDVAFNEG IMRHGAAHIL AVAKAEGRDK VSILTICNTG
     ALATSRYGTA LGVVRQLFYD GKLERVYACE TRPWNQGARL TVYECVQEGI PCTLICDGAA
     SSLMLNRKID AVVVGADRIC QNGDTANKIG TYNLAVSAKF HGVKLYVAAP STTLDAKTAS
     GNRVEIEERE PTEITTNMVT KQRVVADGPH LSVWNPVFDI TPGELITGGI ITEKGVQAPT
     ASAPYYDIAS IIAQP
//

If you have problems or comments...

PBIL Back to PBIL home page