(data stored in SCRATCH3701 zone)

HOGENOM6: LEINT1_1_PE6

ID   LEINT1_1_PE6                         STANDARD;      PRT;   834 AA.
AC   LEINT1_1_PE6; Q8CM44; Q7BAY0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; (LEINT1_1.PE6).
GN   Name=gyrA; OrderedLocusNames=LA_0006;
OS   LEPTOSPIRA INTERROGANS SEROVAR LAI STR. 56601.
OC   Bacteria; Spirochaetes; Spirochaetales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LEINT1_1.PE6.
CC       Leptospira interrogans serovar Lai str. 56601 chromosome chromosome I,
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:Q8CM44_LEPIN
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q8CM44; Q7BAY0; -.
DR   EMBL; AE010300; AAN47205.1; -; Genomic_DNA.
DR   EMBL; AF434658; AAN64016.1; -; Genomic_DNA.
DR   RefSeq; NP_710187.1; NC_004342.2.
DR   HSSP; P09097; 1AB4.
DR   ProteinModelPortal; Q8CM44; -.
DR   SMR; Q8CM44; 54-511.
DR   GeneID; 1149349; -.
DR   GenomeReviews; AE010300_GR; LA0006.
DR   KEGG; lil:LA_0006; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; LEINT1_1.PE6; -.
DR   PRODOM; LEINT1_1_PE6.
DR   SWISS-2DPAGE; LEINT1_1_PE6.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Reference proteome; Topoisomerase.
SQ   SEQUENCE   834 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSQEMENETK VLSYNIAGKP DIADALKNGV RVIPVEIEDQ MKEAYLGYAM SVIVGRALPD
     VRDGLKPVHR RILHAMNERA WRSDRPYVKC AKIVGEVIGN YHPHGDASVY EALVRMVQEF
     SLRVPLIDGQ GNFGSIDGDN PAAYRYTEAR LEKVAEELLR DIEKETVSFS PNYDDTKEQP
     DVLPANFPNL LVNGSSGIAV GMATNIPPHN LRETIDAVIA VIRNPEITIP EILKIIPGPD
     FPTSGIIIGG EGLISAYSTG KGSIRIRSKV EIEEKKNGRE VIVVTEIPYQ VNKKVLLEKI
     GDLVNEKQIE GISEILDLSD RKGIRVEIHI KKDANAQVIL NQLYKMTQLQ VSYGITMLAI
     LDNKPKIFNI KEILTAYAAH RREVIVRRTQ FDLDKAEKRA HILEGLKIAL ENIEDVIKVI
     RASKNPPEAK QQLMIRFSLS EVQSDAILEM RLQRLTSLEV QKIIDELEEV RKLIIDLKDI
     LAKPSRVNEI VCTELQEVGD KYGNKRKTEI SIETIESSSF NAEDLIADEE IVIQITYDQF
     IKRLPIDTFK RQKRGGKGIQ GLSQKRDDVI KIMKAAMTHD NIMFFSNIGK VYVMKAYELP
     IASKEARGKS LKAIINLRED EYISSVFTFR GEDMDKDLLL VTRKGFIKRI QLKEFGNVKK
     SGIIAIGLRE GDELIKVESM TDKDEVMIFS KKGLALRIEG NIIRAQGRTA SGVTGMRLAE
     DDAIVGLSKY KEGEDIFVVS EEGYGKRLGF EEFAAKGRGG KGMAYLKITE KNGFSVGTGS
     VGSEDEIILI TQQGMTIRIN AFDISKLGRT AVGVRIVDLK DNDKVQDFTV LGEN
//

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