(data stored in ACNUC7421 zone)

HOGENOM: LEXYL1_1_PE1005

ID   LEXYL1_1_PE1005                      STANDARD;      PRT;   336 AA.
AC   LEXYL1_1_PE1005; Q6AET2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 3; EC=2.3.1
DE   180;AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase III;AltName:
DE   Full=Beta-ketoacyl-ACP synthase III; (LEXYL1_1.PE1005).
GN   Name=fabH; OrderedLocusNames=Lxx12730;
OS   LEIFSONIA XYLI SUBSP. XYLI STR. CTCB07.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Microbacteriaceae; Leifsonia.
OX   NCBI_TaxID=281090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LEXYL1_1.PE1005.
CC       Leifsonia xyli subsp. xyli str. CTCB07, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:Q6AET2_LEIXX
CC   -!- FUNCTION: Catalyzes the condensation reaction of fatty acid
CC       synthesis by the addition to an acyl acceptor of two carbons from
CC       malonyl-ACP. Catalyzes the first condensation reaction which
CC       initiates fatty acid synthesis and may therefore play a role in
CC       governing the total rate of fatty acid production. Possesses both
CC       acetoacetyl-ACP synthase and acetyl transacylase activities. Its
CC       substrate specificity determines the biosynthesis of branched-
CC       chain and/or straight-chain of fatty acids (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + malonyl-[acyl-carrier-protein] =
CC       acetoacetyl-[acyl-carrier-protein] + CoA + CO(2).
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- DOMAIN: The last Arg residue of the ACP-binding site is essential
CC       for the weak association between ACP/AcpP and FabH (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the fabH family.
CC   -!- GENE_FAMILY: HOG000246674 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q6AET2; -.
DR   EMBL; AE016822; AAT89113.1; -; Genomic_DNA.
DR   RefSeq; YP_062218.1; NC_006087.1.
DR   ProteinModelPortal; Q6AET2; -.
DR   GeneID; 2938658; -.
DR   GenomeReviews; AE016822_GR; Lxx12730.
DR   KEGG; lxx:Lxx12730; -.
DR   NMPDR; fig|281090.3.peg.735; -.
DR   OMA; TIWGSDG; -.
DR   ProtClustDB; PRK09352; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:HAMAP.
DR   GO; GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III activity; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01815; FabH; 1; -.
DR   InterPro; IPR013751; ACP_syn_III.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004655; FabH_synth.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   Pfam; PF08545; ACP_syn_III; 1.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   TIGRFAMs; TIGR00747; FabH; 1.
DR   HOGENOMDNA; LEXYL1_1.PE1005; -.
KW   Acyltransferase; Complete proteome; Cytoplasm;
KW   Fatty acid biosynthesis; Lipid synthesis; Multifunctional enzyme;
KW   Transferase.
SQ   SEQUENCE   336 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTQNRPTLQQ SHGPQHTRIL SIGAARGDLV VPNDDLVGPI DSSDEWIRQR TGIVTRTRAS
     RGLTAVDLAT EAATEAIEKS GVDPKLIDAV IVATISNPQQ TPSLAAVLAD RVGANPAAAY
     DMNAACAGYA YGIAQADALI RTGVAHYALV VGAEKLSDVV DPTDRTISFL LGDGAGAVVI
     GPSEYPGISK TIWGSDGSKA RAVGMGSTLT EFRDGEKPWP TLRQDGQAVF RWAVWEMAKV
     AKQALDAAGV APEHLAAFIP HQANMRIVDE FAKQLKLPET VAIARDIETT GNTSAASIPL
     ATHRLLQENP ELSGGLALQI GFGAGLVFGA QVVVLP
//

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