(data stored in ACNUC7371 zone)

HOVERGEN: LHFP_HUMAN

ID   LHFP_HUMAN              Reviewed;         200 AA.
AC   Q9Y693; B2R7M2; Q53FC0; Q96SH5;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-NOV-2009, entry version 64.
DE   RecName: Full=Lipoma HMGIC fusion partner;
DE   Flags: Precursor;
GN   Name=LHFP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DISEASE.
RX   MEDLINE=99263508; PubMed=10329012; DOI=10.1006/geno.1999.5778;
RA   Petit M.M.R., Schoenmakers E.F.P.M., Huysmans C., Geurts J.M.W.,
RA   Mandahl N., Van de Ven W.J.M.;
RT   "LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a
RT   member of a new family of LHFP-like genes.";
RL   Genomics 57:438-441(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-200.
RC   TISSUE=Dermoid cancer;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- TISSUE SPECIFICITY: Pancreas, kidney, skeletal muscle, liver, lung
CC       brain, heart, colon, small intestine, uterus, testis, prostate,
CC       thymus, spleen and placenta.
CC   -!- DISEASE: A chromosomal aberration involving LHFP is associated
CC       with a subclass of benign mesenchymal tumors known as lipomas.
CC       Translocation t(12;13)(q13-q15;q12) with HMGA2 is shown in
CC       lipomas.
CC   -!- SIMILARITY: Belongs to the LHFP family.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/LHFPID248ch13q12.html";
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CC   -!- GENE_FAMILY: HBG080585 [ FAMILY / ALN / TREE ]
DR   EMBL; AF098807; AAD31386.1; -; mRNA.
DR   EMBL; AL138685; CAH71055.1; -; Genomic_DNA.
DR   EMBL; AL158194; CAH71055.1; JOINED; Genomic_DNA.
DR   EMBL; AL136358; CAH71055.1; JOINED; Genomic_DNA.
DR   EMBL; AL136358; CAC39629.2; -; Genomic_DNA.
DR   EMBL; AL158194; CAC39629.2; JOINED; Genomic_DNA.
DR   EMBL; AL138685; CAC39629.2; JOINED; Genomic_DNA.
DR   EMBL; AL158194; CAH73751.1; -; Genomic_DNA.
DR   EMBL; AL136358; CAH73751.1; JOINED; Genomic_DNA.
DR   EMBL; CH471075; EAX08616.1; -; Genomic_DNA.
DR   EMBL; BC017824; AAH17824.1; -; mRNA.
DR   EMBL; AK223369; BAD97089.1; -; mRNA.
DR   EMBL; AK313036; BAG35869.1; -; mRNA.
DR   RefSeq; NP_005771.1; -.
DR   UniGene; Hs.507798; -.
DR   STRING; Q9Y693; -.
DR   PRIDE; Q9Y693; -.
DR   Ensembl; ENST00000379589; ENSP00000368908; ENSG00000183722; Homo sapiens.
DR   Ensembl; ENST00000449353; ENSP00000398972; ENSG00000183722; Homo sapiens.
DR   GeneID; 10186; -.
DR   KEGG; hsa:10186; -.
DR   UCSC; uc001uxf.1; human.
DR   CTD; 10186; -.
DR   GeneCards; GC13M038815; -.
DR   HGNC; HGNC:6586; LHFP.
DR   MIM; 606710; gene.
DR   PharmGKB; PA30358; -.
DR   HOGENOM; Q9Y693; -.
DR   HOVERGEN; Q9Y693; -.
DR   OMA; CGYISGQ; -.
DR   NextBio; 38550; -.
DR   ArrayExpress; Q9Y693; -.
DR   Bgee; Q9Y693; -.
DR   CleanEx; HS_LHFP; -.
DR   Genevestigator; Q9Y693; -.
DR   GermOnline; ENSG00000183722; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR   InterPro; IPR019372; Lipome_HGMIC_fus_partner-like.
DR   Pfam; PF10242; L_HGMIC_fpl; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9Y693.
DR   SWISS-2DPAGE; Q9Y693.
KW   Chromosomal rearrangement; Complete proteome; Membrane; Signal;
KW   Transmembrane.
FT   DOMAIN        1    200       PRODOM:2005.1:PD332774  22
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    200       Lipoma HMGIC fusion partner.
FT                                /FTId=PRO_0000244756.
FT   TRANSMEM     84    104       Potential.
FT   TRANSMEM    123    143       Potential.
FT   TRANSMEM    166    186       Potential.
SQ   SEQUENCE   200 AA;  21598 MW;  49D1161602966423 CRC64;
     MASSLTCTGV IWALLSFLCA ATSCVGFFMP YWLWGSQLGK PVSFGTFRRC SYPVHDESRQ
     MMVMVEECGR YASFQGIPSA EWRICTIVTG LGCGLLLLVA LTALMGCCVS DLISRTVGRV
     AGGIQFLGGL LIGAGCALYP LGWDSEEVRQ TCGYTSGQFD LGKCEIGWAY YCTGAGATAA
     MLLCTWLACF SGKKQKHYPY
//

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