(data stored in ACNUC7371 zone)

HOVERGEN: LHPL1_HUMAN

ID   LHPL1_HUMAN             Reviewed;         220 AA.
AC   Q86WI0; A8K1N1; Q496M9; Q496N0; Q6UXU2;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-NOV-2009, entry version 37.
DE   RecName: Full=Lipoma HMGIC fusion partner-like 1 protein;
DE   Flags: Precursor;
GN   Name=LHFPL1; ORFNames=UNQ5824/PRO19643;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=15620218; DOI=10.1080/10425170412331279620;
RA   Huang C., Guo J., Liu S., Shan Y., Wu S., Cai Y., Yu L.;
RT   "Isolation, tissue distribution and prokaryotic expression of a novel
RT   human X-linked gene LHFPL1.";
RL   DNA Seq. 15:299-302(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q86WI0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q86WI0-2; Sequence=VSP_019617;
CC         Note=No experimental confirmation available;
CC       Name=3;
CC         IsoId=Q86WI0-3; Sequence=VSP_019616;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Widely expressed. Expressed at high levels in
CC       lung, thymus, skeletal muscle, colon and ovary.
CC   -!- SIMILARITY: Belongs to the LHFP family.
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CC   -!- GENE_FAMILY: HBG080585 [ FAMILY / ALN / TREE ]
DR   EMBL; AY217350; AAO60107.1; -; mRNA.
DR   EMBL; AY358208; AAQ88575.1; ALT_INIT; mRNA.
DR   EMBL; AK289946; BAF82635.1; -; mRNA.
DR   EMBL; BC100785; AAI00786.1; -; mRNA.
DR   EMBL; BC100786; AAI00787.1; -; mRNA.
DR   EMBL; BC100787; AAI00788.1; -; mRNA.
DR   RefSeq; NP_835469.1; -.
DR   UniGene; Hs.297420; -.
DR   PRIDE; Q86WI0; -.
DR   Ensembl; ENST00000371968; ENSP00000361036; ENSG00000182508; Homo sapiens.
DR   GeneID; 340596; -.
DR   KEGG; hsa:340596; -.
DR   UCSC; uc004epp.1; human.
DR   UCSC; uc004epq.1; human.
DR   UCSC; uc010nqb.1; human.
DR   CTD; 340596; -.
DR   GeneCards; GC0XM111680; -.
DR   HGNC; HGNC:6587; LHFPL1.
DR   HPA; HPA003029; -.
DR   MIM; 300566; gene.
DR   PharmGKB; PA30359; -.
DR   HOGENOM; Q86WI0; -.
DR   HOVERGEN; Q86WI0; -.
DR   OMA; GWNSPEV; -.
DR   NextBio; 97979; -.
DR   ArrayExpress; Q86WI0; -.
DR   Bgee; Q86WI0; -.
DR   CleanEx; HS_LHFPL1; -.
DR   Genevestigator; Q86WI0; -.
DR   GermOnline; ENSG00000182508; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019372; Lipome_HGMIC_fus_partner-like.
DR   Pfam; PF10242; L_HGMIC_fpl; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q86WI0.
DR   SWISS-2DPAGE; Q86WI0.
KW   Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW   Signal; Transmembrane.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    220       Lipoma HMGIC fusion partner-like 1
FT                                protein.
FT                                /FTId=PRO_0000244760.
FT   TRANSMEM     14     34       Potential.
FT   TRANSMEM     86    106       Potential.
FT   TRANSMEM    122    142       Potential.
FT   TRANSMEM    165    185       Potential.
FT   CARBOHYD    153    153       N-linked (GlcNAc...) (Potential).
FT   VAR_SEQ       1    179       Missing (in isoform 3).
FT                                /FTId=VSP_019616.
FT   VAR_SEQ     129    161       Missing (in isoform 2).
FT                                /FTId=VSP_019617.
SQ   SEQUENCE   220 AA;  23777 MW;  6BD3E610319E0CF2 CRC64;
     MRSSLTMVGT LWAFLSLVTA VTSSTSYFLP YWLFGSQMGK PVSFSTFRRC NYPVRGEGHS
     LIMVEECGRY ASFNAIPSLA WQMCTVVTGA GCALLLLVAL AAVLGCCMEE LISRMMGRCM
     GAAQFVGGLL ISSGCALYPL GWNSPEIMQT CGNVSNQFQL GTCRLGWAYY CAGGGAAAAM
     LICTWLSCFA GRNPKPVILV ESIMRNTNSY AMELDHCLKP
//

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