(data stored in ACNUC2803 zone)

HOVERGEN: MAGAA_HUMAN

ID   MAGAA_HUMAN             Reviewed;         369 AA.
AC   P43363;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   13-OCT-2009, entry version 68.
DE   RecName: Full=Melanoma-associated antigen 10;
DE   AltName: Full=MAGE-10 antigen;
DE   AltName: Full=Cancer/testis antigen 1.10;
DE            Short=CT1.10;
GN   Name=MAGEA10; Synonyms=MAGE10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=95012457; PubMed=7927540; DOI=10.1007/BF01246677;
RA   De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P.,
RA   De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C.,
RA   Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.;
RT   "Structure, chromosomal localization, and expression of 12 genes of
RT   the MAGE family.";
RL   Immunogenetics 40:360-369(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Not known, though may play a role in embryonal
CC       development and tumor transformation or aspects of tumor
CC       progression.
CC   -!- TISSUE SPECIFICITY: Expressed in many tumors of several types,
CC       such as melanoma, head and neck squamous cell carcinoma, lung
CC       carcinoma and breast carcinoma, but not in normal tissues except
CC       for testes and placenta.
CC   -!- SIMILARITY: Contains 1 MAGE domain.
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CC   -!- GENE_FAMILY: HBG006315 [ FAMILY / ALN / TREE ]
DR   EMBL; U10685; AAA68869.1; -; Genomic_DNA.
DR   EMBL; AC116666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC004105; AAH04105.1; -; mRNA.
DR   IPI; IPI00301104; -.
DR   PIR; I38659; I38659.
DR   RefSeq; NP_001011543.1; -.
DR   RefSeq; NP_066386.1; -.
DR   UniGene; Hs.18048; -.
DR   STRING; P43363; -.
DR   PRIDE; P43363; -.
DR   Ensembl; ENST00000244096; ENSP00000244096; ENSG00000124260; Homo sapiens.
DR   Ensembl; ENST00000370323; ENSP00000359347; ENSG00000124260; Homo sapiens.
DR   Ensembl; ENST00000427322; ENSP00000391977; ENSG00000124260; Homo sapiens.
DR   Ensembl; ENST00000444834; ENSP00000406161; ENSG00000124260; Homo sapiens.
DR   GeneID; 4109; -.
DR   KEGG; hsa:4109; -.
DR   UCSC; uc004ffk.1; human.
DR   CTD; 4109; -.
DR   GeneCards; GC0XM151052; -.
DR   H-InvDB; HIX0017116; -.
DR   H-InvDB; HIX0056573; -.
DR   HGNC; HGNC:6797; MAGEA10.
DR   MIM; 300343; gene.
DR   PharmGKB; PA30543; -.
DR   HOGENOM; P43363; -.
DR   HOVERGEN; P43363; -.
DR   NextBio; 16126; -.
DR   ArrayExpress; P43363; -.
DR   Bgee; P43363; -.
DR   CleanEx; HS_MAGEA10; -.
DR   Genevestigator; P43363; -.
DR   GermOnline; ENSG00000124260; Homo sapiens.
DR   InterPro; IPR002190; MAGE.
DR   PANTHER; PTHR11736; MAGE; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; P43363.
DR   SWISS-2DPAGE; P43363.
KW   Complete proteome; Polymorphism; Tumor antigen.
FT   DOMAIN       66    144       PRODOM:2005.1:PD004857  26
FT   DOMAIN      146    223       PRODOM:2005.1:PDA0A2I5  117
FT   DOMAIN      225    291       PRODOM:2005.1:PD003141  121
FT   DOMAIN      294    330       PRODOM:2005.1:PD031681  112
FT   CHAIN         1    369       Melanoma-associated antigen 10.
FT                                /FTId=PRO_0000156709.
FT   DOMAIN      134    333       MAGE.
FT   COMPBIAS     54     62       Poly-Ser.
FT   VARIANT     166    166       K -> R (in dbSNP:rs210585).
FT                                /FTId=VAR_024528.
FT   VARIANT     234    234       I -> V (in dbSNP:rs210586).
FT                                /FTId=VAR_053496.
SQ   SEQUENCE   369 AA;  40767 MW;  16FA3301CAB716A6 CRC64;
     MPRAPKRQRC MPEEDLQSQS ETQGLEGAQA PLAVEEDASS STSTSSSFPS SFPSSSSSSS
     SSCYPLIPST PEEVSADDET PNPPQSAQIA CSSPSVVASL PLDQSDEGSS SQKEESPSTL
     QVLPDSESLP RSEIDEKVTD LVQFLLFKYQ MKEPITKAEI LESVIKNYED HFPLLFSEAS
     ECMLLVFGID VKEVDPTGHS FVLVTSLGLT YDGMLSDVQS MPKTGILILI LSIIFIEGYC
     TPEEVIWEAL NMMGLYDGME HLIYGEPRKL LTQDWVQENY LEYRQVPGSD PARYEFLWGP
     RAHAEIRKMS LLKFLAKVNG SDPRSFPLWY EEALKDEEER AQDRIATTDD TTAMASASSS
     ATGSFSYPE
//

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