(data stored in ACNUC2803 zone)

HOVERGEN: MAGAC_HUMAN

ID   MAGAC_HUMAN             Reviewed;         314 AA.
AC   P43365; Q9NSD3;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   03-NOV-2009, entry version 76.
DE   RecName: Full=Melanoma-associated antigen 12;
DE   AltName: Full=MAGE-12 antigen;
DE   AltName: Full=MAGE12F antigen;
DE   AltName: Full=Cancer/testis antigen 1.12;
DE            Short=CT1.12;
GN   Name=MAGEA12; Synonyms=MAGE12;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=94102805; PubMed=8276455; DOI=10.1007/BF00188615;
RA   De Smet C., Lurquin C., van der Bruggen P., De Plaen E., Brasseur F.,
RA   Boon T.;
RT   "Sequence and expression pattern of the human MAGE2 gene.";
RL   Immunogenetics 39:121-129(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skin;
RX   MEDLINE=94311935; PubMed=8037761; DOI=10.1006/bbrc.1994.1963;
RA   Ding M., Beck R.J., Keller C.J., Fenton R.G.;
RT   "Cloning and analysis of MAGE-1-related genes.";
RL   Biochem. Biophys. Res. Commun. 202:549-555(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=20314869; PubMed=10854409; DOI=10.1101/gr.10.6.758;
RA   Mallon A.-M., Platzer M., Bate R., Gloeckner G., Botcherby M.R.M.,
RA   Nordsiek G., Strivens M.A., Kioschis P., Dangel A., Cunningham D.,
RA   Straw R.N.A., Weston P., Gilbert M., Fernando S., Goodall K.,
RA   Hunter G., Greystrong J.S., Clarke D., Kimberley C., Goerdes M.,
RA   Blechschmidt K., Rump A., Hinzmann B., Mundy C.R., Miller W.,
RA   Poustka A., Herman G.E., Rhodes M., Denny P., Rosenthal A.,
RA   Brown S.D.M.;
RT   "Comparative genome sequence analysis of the Bpa/Str region in mouse
RT   and man.";
RL   Genome Res. 10:758-775(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Not known, though may play a role in tumor
CC       transformation or aspects of tumor progression.
CC   -!- TISSUE SPECIFICITY: Expressed in many tumors of several types,
CC       such as melanoma, head and neck squamous cell carcinoma, lung
CC       carcinoma and breast carcinoma, but not in normal tissues except
CC       for testes.
CC   -!- SIMILARITY: Contains 1 MAGE domain.
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CC   -!- GENE_FAMILY: HBG006315 [ FAMILY / ALN / TREE ]
DR   EMBL; L18877; AAA19023.1; -; Unassigned_DNA.
DR   EMBL; U82671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BT007108; AAP35772.1; -; mRNA.
DR   EMBL; BC003408; AAH03408.1; -; mRNA.
DR   IPI; IPI00018078; -.
DR   PIR; I54519; I54519.
DR   RefSeq; NP_005358.2; -.
DR   UniGene; Hs.169246; -.
DR   IntAct; P43365; 1.
DR   STRING; P43365; -.
DR   PRIDE; P43365; -.
DR   Ensembl; ENST00000357916; ENSP00000350592; ENSG00000213401; Homo sapiens.
DR   GeneID; 4111; -.
DR   KEGG; hsa:4111; -.
DR   UCSC; uc004fgc.1; human.
DR   CTD; 4111; -.
DR   GeneCards; GC0XM151649; -.
DR   HGNC; HGNC:6799; MAGEA12.
DR   MIM; 300177; gene.
DR   PharmGKB; PA30545; -.
DR   HOGENOM; P43365; -.
DR   HOVERGEN; P43365; -.
DR   OMA; LPTTINY; -.
DR   NextBio; 16138; -.
DR   ArrayExpress; P43365; -.
DR   Bgee; P43365; -.
DR   CleanEx; HS_MAGEA12; -.
DR   Genevestigator; P43365; -.
DR   GermOnline; ENSG00000184324; Homo sapiens.
DR   InterPro; IPR002190; MAGE.
DR   PANTHER; PTHR11736; MAGE; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; P43365.
DR   SWISS-2DPAGE; P43365.
KW   Complete proteome; Polymorphism; Tumor antigen.
FT   DOMAIN        1     33       PRODOM:2005.1:PD612998  16
FT   DOMAIN       45    120       PRODOM:2005.1:PD004857  26
FT   DOMAIN      121    198       PRODOM:2005.1:PDA0A2I5  117
FT   DOMAIN      200    266       PRODOM:2005.1:PD003141  121
FT   DOMAIN      268    295       PRODOM:2005.1:PD031681  112
FT   CHAIN         1    314       Melanoma-associated antigen 12.
FT                                /FTId=PRO_0000156711.
FT   DOMAIN      109    308       MAGE.
FT   COMPBIAS     40     43       Poly-Ser.
FT   VARIANT      57     57       E -> D (in dbSNP:rs16996512).
FT                                /FTId=VAR_053498.
FT   CONFLICT     10     10       C -> S (in Ref. 2).
FT   CONFLICT    187    187       D -> A (in Ref. 1; AAA19023).
FT   CONFLICT    300    300       S -> P (in Ref. 1; AAA19023).
SQ   SEQUENCE   314 AA;  34836 MW;  7E00F7CECD8F6568 CRC64;
     MPLEQRSQHC KPEEGLEAQG EALGLVGAQA PATEEQETAS SSSTLVEVTL REVPAAESPS
     PPHSPQGAST LPTTINYTLW SQSDEGSSNE EQEGPSTFPD LETSFQVALS RKMAELVHFL
     LLKYRAREPF TKAEMLGSVI RNFQDFFPVI FSKASEYLQL VFGIEVVEVV RIGHLYILVT
     CLGLSYDGLL GDNQIVPKTG LLIIVLAIIA KEGDCAPEEK IWEELSVLEA SDGREDSVFA
     HPRKLLTQDL VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHL LKISGGPHIS
     YPPLHEWAFR EGEE
//

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