(data stored in ACNUC2803 zone)

HOVERGEN: MAGB6_HUMAN

ID   MAGB6_HUMAN             Reviewed;         407 AA.
AC   Q8N7X4; Q6GS19; Q9H219;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 2.
DT   03-NOV-2009, entry version 53.
DE   RecName: Full=Melanoma-associated antigen B6;
DE   AltName: Full=MAGE-B6 antigen;
DE   AltName: Full=Cancer/testis antigen 3.4;
DE            Short=CT3.4;
GN   Name=MAGEB6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-177, AND TISSUE SPECIFICITY.
RC   TISSUE=Blood;
RX   MEDLINE=20321428; PubMed=10861452;
RX   DOI=10.1002/1097-0215(20000701)87:1<55::AID-IJC8>3.3.CO;2-A;
RA   Lucas S., De Plaen E., Boon T.;
RT   "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE
RT   family with tumor-specific expression.";
RL   Int. J. Cancer 87:55-60(2000).
CC   -!- TISSUE SPECIFICITY: Expressed in testis. Not expressed in other
CC       normal tissues, but is expressed in tumors of different
CC       histological origins.
CC   -!- SIMILARITY: Contains 1 MAGE domain.
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CC   -!- GENE_FAMILY: HBG006315 [ FAMILY / ALN / TREE ]
DR   EMBL; AK097561; BAC05102.1; -; mRNA.
DR   EMBL; BC067286; AAH67286.1; -; mRNA.
DR   EMBL; BC074920; AAH74920.1; -; mRNA.
DR   EMBL; AF320514; AAG48624.1; -; Genomic_DNA.
DR   IPI; IPI00297989; -.
DR   RefSeq; NP_775794.2; -.
DR   UniGene; Hs.376011; -.
DR   PRIDE; Q8N7X4; -.
DR   Ensembl; ENST00000379034; ENSP00000368320; ENSG00000176746; Homo sapiens.
DR   Ensembl; ENST00000397565; ENSP00000380696; ENSG00000176746; Homo sapiens.
DR   GeneID; 158809; -.
DR   KEGG; hsa:158809; -.
DR   UCSC; uc004dbr.1; human.
DR   CTD; 158809; -.
DR   GeneCards; GC0XP026120; -.
DR   H-InvDB; HIX0077221; -.
DR   HGNC; HGNC:23796; MAGEB6.
DR   MIM; 300467; gene.
DR   PharmGKB; PA134864191; -.
DR   HOGENOM; Q8N7X4; -.
DR   HOVERGEN; Q8N7X4; -.
DR   OMA; NGQDEKS; -.
DR   NextBio; 87819; -.
DR   ArrayExpress; Q8N7X4; -.
DR   Bgee; Q8N7X4; -.
DR   CleanEx; HS_MAGEB6; -.
DR   Genevestigator; Q8N7X4; -.
DR   GermOnline; ENSG00000176746; Homo sapiens.
DR   InterPro; IPR002190; MAGE.
DR   PANTHER; PTHR11736; MAGE; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q8N7X4.
DR   SWISS-2DPAGE; Q8N7X4.
KW   Complete proteome; Tumor antigen.
FT   DOMAIN        1     37       PRODOM:2005.1:PD031671  22
FT   DOMAIN       46    208       PRODOM:2005.1:PD631705  1
FT   DOMAIN      209    284       PRODOM:2005.1:PDA0A2I5  117
FT   DOMAIN      286    352       PRODOM:2005.1:PD003141  121
FT   DOMAIN      353    391       PRODOM:2005.1:PD031681  112
FT   CHAIN         1    407       Melanoma-associated antigen B6.
FT                                /FTId=PRO_0000156717.
FT   DOMAIN      195    394       MAGE.
FT   COMPBIAS     38    164       Ser-rich.
FT   CONFLICT    172    172       G -> R (in Ref. 1; BAC05102).
SQ   SEQUENCE   407 AA;  43992 MW;  3674F422020355DA CRC64;
     MPRGHKSKLR TCEKRQETNG QPQGLTGPQA TAEKQEESHS SSSSSRACLG DCRRSSDASI
     PQESQGVSPT GSPDAVVSYS KSDVAANGQD EKSPSTSRDA SVPQESQGAS PTGSPDAGVS
     GSKYDVAANG QDEKSPSTSH DVSVPQESQG ASPTGSPDAG VSGSKYDVAA EGEDEESVSA
     SQKAIIFKRL SKDAVKKKAC TLAQFLQKKF EKKESILKAD MLKCVRREYK PYFPQILNRT
     SQHLVVAFGV ELKEMDSSGE SYTLVSKLGL PSEGILSGDN ALPKSGLLMS LLVVIFMNGN
     CATEEEVWEF LGLLGIYDGI LHSIYGDARK IITEDLVQDK YVVYRQVCNS DPPCYEFLWG
     PRAYAETTKM RVLRVLADSS NTSPGLYPHL YEDALIDEVE RALRLRA
//

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