(data stored in ACNUC2803 zone)

HOVERGEN: MAGBI_HUMAN

ID   MAGBI_HUMAN             Reviewed;         343 AA.
AC   Q96M61;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   13-OCT-2009, entry version 47.
DE   RecName: Full=Melanoma-associated antigen B18;
DE   AltName: Full=MAGE-B18 antigen;
GN   Name=MAGEB18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q06547:GABPB1; NbExp=2; IntAct=EBI-741835, EBI-618165;
CC       Q15025:TNIP1; NbExp=1; IntAct=EBI-741835, EBI-357849;
CC   -!- SIMILARITY: Contains 1 MAGE domain.
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CC   -!- GENE_FAMILY: HBG006315 [ FAMILY / ALN / TREE ]
DR   EMBL; AK057361; BAB71450.1; -; mRNA.
DR   EMBL; BC029525; AAH29525.1; -; mRNA.
DR   IPI; IPI00065350; -.
DR   RefSeq; NP_775970.1; -.
DR   UniGene; Hs.350683; -.
DR   IntAct; Q96M61; 5.
DR   STRING; Q96M61; -.
DR   PRIDE; Q96M61; -.
DR   Ensembl; ENST00000325250; ENSP00000314543; ENSG00000176774; Homo sapiens.
DR   GeneID; 286514; -.
DR   KEGG; hsa:286514; -.
DR   UCSC; uc004dbq.1; human.
DR   CTD; 286514; -.
DR   GeneCards; GC0XP026066; -.
DR   HGNC; HGNC:28515; MAGEB18.
DR   PharmGKB; PA142671483; -.
DR   HOGENOM; Q96M61; -.
DR   HOVERGEN; Q96M61; -.
DR   NextBio; 96247; -.
DR   ArrayExpress; Q96M61; -.
DR   Bgee; Q96M61; -.
DR   CleanEx; HS_MAGEB18; -.
DR   Genevestigator; Q96M61; -.
DR   GermOnline; ENSG00000176774; Homo sapiens.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   InterPro; IPR002190; MAGE.
DR   PANTHER; PTHR11736; MAGE; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q96M61.
DR   SWISS-2DPAGE; Q96M61.
KW   Complete proteome; Polymorphism; Tumor antigen.
FT   DOMAIN        1     36       PRODOM:2005.1:PD031671  22
FT   DOMAIN       37    118       PRODOM:2005.1:PD767587  1
FT   DOMAIN      119    196       PRODOM:2005.1:PDA0A2I5  117
FT   DOMAIN      198    264       PRODOM:2005.1:PD003141  121
FT   DOMAIN      265    303       PRODOM:2005.1:PD031681  112
FT   CHAIN         1    343       Melanoma-associated antigen B18.
FT                                /FTId=PRO_0000156719.
FT   DOMAIN      107    306       MAGE.
FT   VARIANT      40     40       S -> P (in dbSNP:rs5944317).
FT                                /FTId=VAR_053500.
SQ   SEQUENCE   343 AA;  38523 MW;  C1E9286D8545EC87 CRC64;
     MPRGQKSKLR AREKRHQARC ENQDLGATQA TVAEGESPSS AYLLFGDRPQ NLPAAETPSI
     PEALQGAPST TNAIAPVSCS SNEGASSQDE KSLGSSREAE GWKEDPLNKK VVSLVHFLLQ
     KYETKEPITK GDMIKFVIRK DKCHFNEILK RASEHMELAL GVDLKEVDPI RHYYAFFSKL
     DLTYDETTSD EEKIPKTGLL MIALGVIFLN GNRAPEEAVW EIMNMMGVYA DRKHFLYGDP
     RKVMTKDLVQ LKYLEYQQVP NSDPPRYEFL WGPRAHAETS KMKVLEFVAK IHDTVPSAFP
     SCYEEALRDE EQRTQARAAA RAHTAAMANA RSRTTSSSFS HAK
//

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