(data stored in ACNUC2803 zone)

HOVERGEN: MAGG1_MOUSE

ID   MAGG1_MOUSE             Reviewed;         279 AA.
AC   Q9CPR8; Q569V7; Q9D378;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-NOV-2009, entry version 56.
DE   RecName: Full=Melanoma-associated antigen G1;
DE   AltName: Full=MAGE-G1 antigen;
DE   AltName: Full=Necdin-like protein 2;
GN   Name=Ndnl2; Synonyms=Mageg1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Auquier P.H., Chomez P.M., De Backer O.R., Bertrand M.J.M.;
RT   "Ten new murine members of the MAGE gene family.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RC   TISSUE=Embryo, Embryonic stem cell, Head, Medulla oblongata, and
RC   Spinal cord;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=11782285; DOI=10.1186/1471-2156-2-22;
RA   Chibuk T.K., Bischof J.M., Wevrick R.;
RT   "A necdin/MAGE-like gene in the chromosome 15 autism susceptibility
RT   region: expression, imprinting, and mapping of the human and mouse
RT   orthologues.";
RL   BMC Genet. 2:22-22(2001).
RN   [5]
RP   INTERACTION WITH E2F1 AND NGFR, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=14593116; DOI=10.1074/jbc.M308454200;
RA   Kuwako K., Taniura H., Yoshikawa K.;
RT   "Necdin-related MAGE proteins differentially interact with the E2F1
RT   transcription factor and the p75 neurotrophin receptor.";
RL   J. Biol. Chem. 279:1703-1712(2004).
CC   -!- FUNCTION: Growth suppressor that facilitates the entry of the cell
CC       into cell cycle arrest.
CC   -!- SUBUNIT: Binds the C-terminus of E2F1 and NGFR.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Contains 1 MAGE domain.
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CC   -!- GENE_FAMILY: HBG006315 [ FAMILY / ALN / TREE ]
DR   EMBL; AF319979; AAK01207.1; -; mRNA.
DR   EMBL; AK010294; BAB26830.1; -; mRNA.
DR   EMBL; AK017727; BAB30899.1; -; mRNA.
DR   EMBL; AK018250; BAB31133.1; -; mRNA.
DR   EMBL; AK049759; BAC33907.1; -; mRNA.
DR   EMBL; AK076471; BAC36358.1; -; mRNA.
DR   EMBL; BC034892; AAH34892.1; -; mRNA.
DR   EMBL; BC092289; AAH92289.2; -; mRNA.
DR   IPI; IPI00131850; -.
DR   RefSeq; NP_075728.1; -.
DR   UniGene; Mm.19944; -.
DR   STRING; Q9CPR8; -.
DR   PhosphoSite; Q9CPR8; -.
DR   PRIDE; Q9CPR8; -.
DR   Ensembl; ENSMUST00000094331; ENSMUSP00000091889; ENSMUSG00000070520; Mus musculus.
DR   GeneID; 66647; -.
DR   KEGG; mmu:66647; -.
DR   UCSC; uc009hgm.1; mouse.
DR   CTD; 66647; -.
DR   MGI; MGI:1913897; Ndnl2.
DR   HOVERGEN; Q9CPR8; -.
DR   OMA; IKETEVW; -.
DR   NextBio; 322269; -.
DR   ArrayExpress; Q9CPR8; -.
DR   Bgee; Q9CPR8; -.
DR   CleanEx; MM_NDNL2; -.
DR   Genevestigator; Q9CPR8; -.
DR   GermOnline; ENSMUSG00000070520; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.
DR   InterPro; IPR002190; MAGE.
DR   PANTHER; PTHR11736; MAGE; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q9CPR8.
DR   SWISS-2DPAGE; Q9CPR8.
KW   Cytoplasm; Growth regulation; Nucleus; Phosphoprotein; Tumor antigen.
FT   DOMAIN        1     70       PRODOM:2005.1:PD392481  2
FT   DOMAIN       71    129       PRODOM:2005.1:PDA0A2I5  117
FT   DOMAIN      151    217       PRODOM:2005.1:PD003141  121
FT   DOMAIN      219    256       PRODOM:2005.1:PD031681  112
FT   CHAIN         1    279       Melanoma-associated antigen G1.
FT                                /FTId=PRO_0000156734.
FT   DOMAIN       59    259       MAGE.
FT   MOD_RES      38     38       Phosphoserine (By similarity).
FT   CONFLICT     36     36       G -> A (in Ref. 2; BAB31133).
SQ   SEQUENCE   279 AA;  31460 MW;  FE2435919BD63160 CRC64;
     MLQKPRGRGR PSTQADPERD WGGAGEEGPS TSRAAGGSSQ GSRASLSAPT VGPRTQKQLE
     LKVAELVQFL LIKDQKKIPI KRTDILKHVV GDYRDVYPNL LKLAAERLQY VFGYKLVELE
     PKSHSYILIN MLEPVEADAE MRGDQGTPIS GLLMIVLGLI FMKGNTITET EVWDFLRRLG
     VYPTKKHLIF GDPKKLITED FVRQRYLEYR RIPHTDPVDY ELQWGPRTNL ETSKMKVLKF
     VAKVHNQDPK DWPTQYCEAL ADEESRARPA TASAPATSS
//

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