(data stored in SCRATCH3701 zone)

HOGENOM6: MEISD_1_PE2379

ID   MEISD_1_PE2379                       STANDARD;      PRT;   805 AA.
AC   MEISD_1_PE2379; D7BAV3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (MEISD_1.PE2379).
GN   OrderedLocusNames=Mesil_2474;
OS   MEIOTHERMUS SILVANUS DSM 9946.
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae;
OC   Meiothermus.
OX   NCBI_TaxID=526227;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MEISD_1.PE2379.
CC       Meiothermus silvanus DSM 9946 chromosome, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:D7BAV3_MEISD
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D7BAV3; -.
DR   EMBL; CP002042; ADH64327.1; -; Genomic_DNA.
DR   RefSeq; YP_003685835.1; NC_014212.1.
DR   GeneID; 9251990; -.
DR   GenomeReviews; CP002042_GR; Mesil_2474.
DR   KEGG; msv:Mesil_2474; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; MEISD_1.PE2379; -.
DR   PRODOM; MEISD_1_PE2379.
DR   SWISS-2DPAGE; MEISD_1_PE2379.
KW   DNA gyrase, A subunit;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   805 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSQVLPIEIT EEVKQSFINY AMSTIVDRAL PDVRDGLKPV QRRILYAAQQ EGLIPTRKHS
     KSAGIVGEVM KKYHPHGDAA IYDTLARLAQ PWNQRYPLID GQGNFGSIDG DPPAAQRYTE
     ARLSSIGYEM LRDIDKETVN FYPNYDGTTE QPEVLPAAIP NLLVNGSTGI AVGMATSIPP
     HNLSEVIDAL VALIDQPGLS LDEIMKLLPG PDFPTGARLS RKGIREAYAS GRGSLKVRAK
     VRNEDKNGRA MLVFTEIPYQ VNKADLIAQI AGLAKNKVIE EIAALRDESD RQGMRIAVEL
     KRGANPQVVL NKLYKHSRLQ ASFTVNLLAI VNGEPKVLSL PELLRHYLNH RREVVYRRTQ
     YELSEAKKRA HVLEGLLIAL DHIDEVIALI RGSADANEAR TGLIARFALS DIQAQAILDM
     RLQRLVGLER EKLQEEYREL QETIAYLSAI LQDEKRLWGV VKEELLEIKN KYGDARRTQL
     TEFEEGFNPE DLIEDEPMVI TLTSQGFLKR TPLEAYRAQG RGGVGAQAGK TKEEDEAVQV
     FVASMHDDLL FFTNRGRVYR EKVFELPEAS RQARGTHVVS MLPLIEGEEV AALLGVRSLS
     EAGYFVFATR QGLIKRTEIQ EYQNLSSAGL IAINLLENDA LIGVGIAQDG EQIMLATAYG
     QAIRFDLEDV RATGRASQGV TGIRFKDEGD QVVSLVILPK GYEGEVLAVG TKGYGKRTSV
     AEYPVQGRGG QGVITFKTTE KVGKLAALMR VAGDEDLLVL SRRGIAIRTK VGSISLYGRP
     TSGVKIMNLA EDDEVVSAFV IKPQD
//

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