(data stored in ACNUC7421 zone)

HOGENOM: MEMAR1_1_PE1009

ID   MEMAR1_1_PE1009                      STANDARD;      PRT;   418 AA.
AC   MEMAR1_1_PE1009; Q6LYI2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dihydroorotase; EC=3.5.2 3; (MEMAR1_1.PE1009).
GN   Name=pyrC; OrderedLocusNames=MMP1009;
OS   METHANOCOCCUS MARIPALUDIS S2.
OC   Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanococcaceae;
OC   Methanococcus.
OX   NCBI_TaxID=267377;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MEMAR1_1.PE1009.
CC       Methanococcus maripaludis S2 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:Q6LYI2_METMP
CC   -!- CATALYTIC ACTIVITY: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-
CC       aspartate.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; (S)-dihydroorotate from bicarbonate: step 3/3.
CC   -!- SIMILARITY: Belongs to the DHOase family. Type 2 subfamily.
CC   -!- GENE_FAMILY: HOG000219143 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q6LYI2; -.
DR   EMBL; BX950229; CAF30565.1; -; Genomic_DNA.
DR   RefSeq; NP_988129.1; NC_005791.1.
DR   ProteinModelPortal; Q6LYI2; -.
DR   MEROPS; M38.972; -.
DR   GeneID; 2762218; -.
DR   GenomeReviews; BX950229_GR; MMP1009.
DR   KEGG; mmp:MMP1009; -.
DR   NMPDR; fig|267377.1.peg.1009; -.
DR   OMA; GKFNPPL; -.
DR   ProtClustDB; CLSK876595; -.
DR   GO; GO:0004151; F:dihydroorotase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00220_A; PyrC_type2_A; 1; -.
DR   InterPro; IPR006680; Amidohydro_1.
DR   InterPro; IPR004722; DHOase.
DR   InterPro; IPR002195; Dihydroorotase_CS.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; Metalo_hydrolase; 1.
DR   TIGRFAMs; TIGR00857; PyrC_multi; 1.
DR   PROSITE; PS00482; DIHYDROOROTASE_1; 1.
DR   PROSITE; PS00483; DIHYDROOROTASE_2; 1.
DR   HOGENOMDNA; MEMAR1_1.PE1009; -.
KW   Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis;
KW   Zinc.
SQ   SEQUENCE   418 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVLLKNGKIV SENKITESDI LIEDGIIQKI EKNIDYSGET IDLKGNYVFP GFIDSHVHFR
     WGNPEKEDFL SGSEAAIAGG IVYAIDMPNN TPPVTTKEIF YKKMKEGNEK SKINLYFAYG
     VTENNYLENV EEAIFYKIFM VKSVGDLFIS DYSKLREILD QNKIFAIHAE HKNVILENSK
     KYELNSFKNH CKIRSRESEI EAVKEVLEVL QKIDKESKNK PNVHFCHISV KEALDLIKNA
     KKTFKNVKVT VEVSPHHLFL NSKMAEDLKG CGKFNPPLRE EADNLALLNG IIDGTVDVVA
     TDHAPHLLNE KLNVVEKCPS GIPGIETLVP LIMNLVNEGK ISIFDAYRVL SKNPSKIFKI
     NNKIEIGNSA NMTVVDMDKE YKISAKDFKS KAKFTPFEGK TVKGKPFATL VNGKIYIL
//

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