(data stored in SCRATCH3701 zone)

HOGENOM6: METEA_5_PE476

ID   METEA_5_PE476                        STANDARD;      PRT;   894 AA.
AC   METEA_5_PE476; C5B4N9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; (METEA_5.PE476).
GN   Name=gyrA; OrderedLocusNames=MexAM1_META2p0574;
OS   METHYLOBACTERIUM EXTORQUENS AM1.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=272630;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS METEA_5.PE476.
CC       Methylobacterium extorquens AM1 megaplasmid, complete sequence.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:C5B4N9_METEA
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C5B4N9; -.
DR   EMBL; CP001511; ACS43421.1; -; Genomic_DNA.
DR   RefSeq; YP_002966762.1; NC_012811.1.
DR   STRING; C5B4N9; -.
DR   GeneID; 7995871; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 5.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; METEA_5.PE476; -.
DR   PRODOM; METEA_5_PE476.
DR   SWISS-2DPAGE; METEA_5_PE476.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Plasmid; Topoisomerase.
SQ   SEQUENCE   894 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQVEGTEVDH ADEGVAAVKR TSFTEEMEDS YLSYMMSTVT ARALPDVRDG MKPVHRRIMF
     SMAESNFTAD RKHVKSAKVV GDVMGQYHPH GDTAIYDAMV RMGQHWSLRY PLIDPQGNFG
     SIDNDPPAAM RYTESRLERL AGHLVADLGE GVVDFRPNYD SSCKEPVVLP ARFPNLLVNG
     GIGIAVGMAT NIPPHHLGET IEACLLRLAN PAVTLDEIMR VMPGPDLPTG GVIHGRSGIR
     QAFATGRGAI RVSGVASVEE GKAGRRRIVI AQLPYLVVKA EFVEKLAELV EEKKIEGISD
     IRDESSDKAG IRIVIDVRKD ADPAVVLNRL REKTDFVTNL NVNMTCLDSR GRPRTMGVLQ
     VLGEFVDFRR EVVRRRTMHR LEKTREDLHR QIGLYAATLR IDEIVALIRS SHDIDEARAA
     LLALDFDTSG EFAQLLFEVD PDVPVGDTFR LSDAQVRAIL EMRLSRLTGL ERDKIAERAR
     ELSVEIGGHL EILNVKAVLD GVVRRELEEI KAAFPDGRRT AIEDSALDAL SDEDLVELKD
     IVVTVTAGGY VKRTDLPAYM GRQKAADEAV EDPVATTIVC TTKTPLLFFT NRGLAHAEVA
     HKLPEAAPNV RGRALVNFLE LKAEETVQAI VALPDDRAAI EKLSLIFVTD FGTIRRNDAS
     DFARVNKGGK VAIKLEDENG EPQGKLVSVL LVSPEDDVAL ASRDGLCCRF NVADLRVMKS
     RDSVGVAGIS LGRKDKVISV SVLRHFEATG TEREAYLAGG SARTKDETTG EPATFELPSD
     RMLAMQEAEQ LILSVTENGF AKRTSSHAYR ITARGGQGVE AAKLADRTGD LVALMPVEEQ
     DVLVITTDAG KTFRTSAAEV PIMARGTQGT RAFALEGRQA IVSVVKIAAE PAAK
//

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