(data stored in SCRATCH3701 zone)

HOGENOM6: METS4_3_PE4200

ID   METS4_3_PE4200                       STANDARD;      PRT;   914 AA.
AC   METS4_3_PE4200; B0UMW0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (METS4_3.PE4200).
GN   OrderedLocusNames=M446_4447;
OS   METHYLOBACTERIUM SP. 4-46.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426117;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS METS4_3.PE4200.
CC       Methylobacterium sp. 4-46 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:B0UMW0_METS4
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B0UMW0; -.
DR   EMBL; CP000943; ACA18788.1; -; Genomic_DNA.
DR   RefSeq; YP_001771222.1; NC_010511.1.
DR   ProteinModelPortal; B0UMW0; -.
DR   SMR; B0UMW0; 40-523.
DR   STRING; B0UMW0; -.
DR   GeneID; 6133436; -.
DR   GenomeReviews; CP000943_GR; M446_4447.
DR   KEGG; met:M446_4447; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; METS4_3.PE4200; -.
DR   PRODOM; METS4_3_PE4200.
DR   SWISS-2DPAGE; METS4_3_PE4200.
KW   DNA gyrase, A subunit;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   914 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTLAEKDETG APPPASDIKP VSITDEMRRS YLDYAMSVIV SRALPDARDG LKPVHRRILY
     SMYENGYLPE RKYVKSARIV GDVMGQYHPH GDQSIYDALV RMAQDFAMRL MLVDGQGNFG
     SIDGDPPAAM RYTESRLAKP AMALLEDIDK NTVDFNPNYD ESKDEPAVLP ARFPNLLVNG
     AGGIAVGMAT NIPPHNLGEV IEGCIALIDD PALTIEGLNE IIPGPDFPTG GQILGRAGTR
     AAYMTGRGSV IMRAKSHVEE IRKEREALVF TEIPYQVNKA SLVEKIAELV RDKRIEGVSD
     LRDESDRDGM RIVVELKRDA MADVVLNQLY RYTPLQTSFG CNMVALNGGR PELLNLKDLI
     QAFIDFREEV VSRRTKFLLR KARERAHVLC GLAIAVANID EVIRLIRTSP DPNSAREALM
     ARDWPAVDIA PLIALVDDPR HRVADDGTYR LSDAQARAIL DLRLQRLTAL GRDEVGDELK
     QLADEIADYL DILRSRARIL GIVKAELAEV RAEFATPRRT EIQDWDSTVE DEDLIQREDM
     VVTVSHAGYI KRVPLSTYRA QRRGGKGRSG MTTRDEDFVT RLFVANTHTP VLFFSSQGQA
     YKEKVWRLPL AAPNARGKAL VNILPLDTSG ERITTIMPLP EDEASWETLD VMFATASGHV
     RRNKLSDFVQ VNRNGKIAMK LDEGDHIVHV EICTEADDVL LTTAAGQCIR FPVTDVRVFK
     GRDSTGVRGI NLGSGDRVIS MTILRHFEAT PEERQAYLRR ANADRRATGE AIELPATPEA
     DGEETAASID LDQERYIAMG AAEQFVLTLS ERGFGKRTSS FEYRISGRGG KGIKAMEVNT
     RNGHLVASFP VETSDQIMLV TNGGQLIRVP VDDIRIVGRA SQGVTVFNTA KDERVVSVEH
     IEGEGESEEE GEGN
//

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