(data stored in ACNUC30630 zone)

HOGENOM: METTM_1_PE231

ID   METTM_1_PE231                        STANDARD;      PRT;   461 AA.
AC   METTM_1_PE231; P26940; D9PUE5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (METTM_1.PE231).
GN   Name=trpE; OrderedLocusNames=MTBMA_c02340;
OS   METHANOTHERMOBACTER MARBURGENSIS STR. MARBURG.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=79929;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS METTM_1.PE231.
CC       Methanothermobacter marburgensis str. Marburg chromosome, complete geno
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:TRPE_METTM
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P26940; D9PUE5; -.
DR   EMBL; M65060; AAA73028.1; -; Genomic_DNA.
DR   EMBL; CP001710; ADL57843.1; -; Genomic_DNA.
DR   RefSeq; YP_003849156.1; NC_014408.1.
DR   ProteinModelPortal; P26940; -.
DR   GeneID; 9703940; -.
DR   GenomeReviews; CP001710_GR; MTBMA_c02340.
DR   KEGG; mmg:MTBMA_c02340; -.
DR   OMA; VRSLMDI; -.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR010116; Anthranilate_synth_I_arc.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   TIGRFAMs; TIGR01820; TrpE-arch; 1.
DR   HOGENOMDNA; METTM_1.PE231; -.
KW   anthranilate synthase component I;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Tryptophan biosynthesis.
SQ   SEQUENCE   461 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGVNVFGIIN LEKPRKEKLE FREPFEVFKS IYSEYESSFL LESMESDTGL ARYSFIGFEP
     EMIIRAREGV IEIDDGDSRE EFDSKNPFED LRGFLKMEKN SGGFCGGLVG YISYQAARFF
     DTIRLSEGDF PDFEFGLFLD GIMFNHLTGE CSYISRHGNR LPDISPLLGD EVPTGTLGYR
     RERTLLSKRR YMDMVLEAKE RIREGEIFQA VLSSATDYRL RGDRLAFYES LRRINPSPYM
     YHLKLGEREI TGSSPEMLVR VEDRRIETFP IAGTRPRGRT EEEDGVIASD LLSDEKELAE
     HLMLVDLARN DIGRVSEFGS VEVPEYMTIK RFSHVQHILS HVTGKLRDGM DAVDALGAVF
     PAGTVSGAPK IRAMEIIESL EGVPRNAYAG ALGYLSLNGN ADFAITIRSM VCQGKTGRIQ
     AGAGIVHDSI PEMEYLECQN KARALLKSME MAGEQVDPDN R
//

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