(data stored in ACNUC1130 zone)

HOVERGEN: MET_HYLLE

ID   MET_HYLLE               Reviewed;        1390 AA.
AC   Q07DY1;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   13-OCT-2009, entry version 28.
DE   RecName: Full=Hepatocyte growth factor receptor;
DE            Short=HGF receptor;
DE            EC=2.7.10.1;
DE   AltName: Full=Scatter factor receptor;
DE            Short=SF receptor;
DE   AltName: Full=HGF/SF receptor;
DE   AltName: Full=Met proto-oncogene tyrosine kinase;
DE   AltName: Full=c-Met;
DE   Flags: Precursor;
GN   Name=MET;
OS   Hylobates leucogenys (White-cheeked gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Antonellis A., Ayele K., Benjamin B., Blakesley R.W., Boakye A.,
RA   Bouffard G.G., Brinkley C., Brooks S., Chu G., Coleman H., Engle J.,
RA   Gestole M., Greene A., Guan X., Gupta J., Haghighi P., Han J.,
RA   Hansen N., Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Kwong P.,
RA   Laric P., Larson S., Lee-Lin S.-Q., Legaspi R., Madden M.,
RA   Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C., Maskeri B.,
RA   McDowell J., Mojidi H.A., Mullikin J.C., Oestreicher J.S., Park M.,
RA   Portnoy M.E., Prasad A., Puri O., Reddix-Dugue N., Schandler K.,
RA   Schueler M.G., Sison C., Stantripop S., Stephen E., Taye A.,
RA   Thomas J.W., Thomas P.J., Tsipouri V., Ung L., Vogt J.L.,
RA   Wetherby K.D., Young A., Green E.D.;
RT   "NISC comparative sequencing initiative.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for hepatocyte growth factor and scatter
CC       factor. Has a tyrosine-protein kinase activity. Functions in cell
CC       proliferation, scattering, morphogenesis and survival (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC       [protein]-L-tyrosine phosphate.
CC   -!- SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta
CC       chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2.
CC       Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356,
CC       interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as
CC       well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the
CC       presence and in the absence of HGF, however HGF treatment has a
CC       positive effect on this interaction. Interacts with MUC20;
CC       prevents interaction with GRB2 and suppresses hepatocyte growth
CC       factor-induced cell proliferation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- DOMAIN: The kinase domain is involved in SPSB1 binding (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
CC   -!- SIMILARITY: Contains 3 IPT/TIG domains.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- SIMILARITY: Contains 1 Sema domain.
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CC   -!- GENE_FAMILY: HBG006348 [ FAMILY / ALN / TREE ]
DR   EMBL; DP000194; ABJ08861.1; -; Genomic_DNA.
DR   SMR; Q07DY1; 40-564, 1046-1346.
DR   HOVERGEN; Q07DY1; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kin...; IEA:EC.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR002909; IPT_TIG_rcpt.
DR   InterPro; IPR003659; Plexin-like.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001627; Semaphorin/CD100_Ag.
DR   InterPro; IPR001245; Tyr_pkinase.
DR   InterPro; IPR008266; Tyr_pkinase_AS.
DR   InterPro; IPR016244; TyrPK_HGF-R.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 3.
DR   PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q07DY1.
DR   SWISS-2DPAGE; Q07DY1.
KW   ATP-binding; Disulfide bond; Glycoprotein; Kinase; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Repeat;
KW   Signal; Transferase; Transmembrane; Tyrosine-protein kinase.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25   1390       Hepatocyte growth factor receptor.
FT                                /FTId=PRO_0000260424.
FT   TOPO_DOM     25    932       Extracellular (Potential).
FT   TRANSMEM    933    955       Potential.
FT   TOPO_DOM    956   1390       Cytoplasmic (Potential).
FT   DOMAIN       27    515       Sema.
FT   DOMAIN      563    655       IPT/TIG 1.
FT   DOMAIN      657    739       IPT/TIG 2.
FT   DOMAIN      742    836       IPT/TIG 3.
FT   DOMAIN     1078   1345       Protein kinase.
FT   NP_BIND    1084   1092       ATP (By similarity).
FT   REGION     1212   1381       Interaction with RANBP9 (By similarity).
FT   REGION     1320   1359       Interaction with MUC20 (By similarity).
FT   ACT_SITE   1204   1204       Proton acceptor (By similarity).
FT   BINDING    1110   1110       ATP (By similarity).
FT   SITE        307    308       Cleavage (Potential).
FT   MOD_RES     966    966       Phosphoserine (By similarity).
FT   MOD_RES     977    977       Phosphothreonine (By similarity).
FT   MOD_RES     988    988       Phosphoserine (By similarity).
FT   MOD_RES     990    990       Phosphoserine (By similarity).
FT   MOD_RES     997    997       Phosphoserine (By similarity).
FT   MOD_RES    1000   1000       Phosphoserine (By similarity).
FT   MOD_RES    1003   1003       Phosphotyrosine (By similarity).
FT   MOD_RES    1230   1230       Phosphotyrosine (By similarity).
FT   MOD_RES    1234   1234       Phosphotyrosine (By similarity).
FT   MOD_RES    1235   1235       Phosphotyrosine; by autocatalysis (By
FT                                similarity).
FT   MOD_RES    1356   1356       Phosphotyrosine (By similarity).
FT   CARBOHYD     45     45       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    106    106       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    149    149       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    202    202       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    399    399       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    405    405       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    607    607       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    635    635       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    785    785       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    879    879       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    930    930       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   1390 AA;  155521 MW;  0A68DAFE46333CAF CRC64;
     MKTPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSKMNVNMK YQLPNFTAET PIQNVILHEH
     HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL
     VVDTYYDDQL ISCGSINRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPS QCPDCVVSAL
     GAKVLSSVKD RFINFFVGNT INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE
     FRDSYPIKYV HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL
     TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS
     AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRTEF
     TTALQRVDLF MGQFSEVLLT SVSTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL
     LDSHPVSPEV IVEHPLNQNG YTLVVTGKKI TKIPLSGLGC RHFQSCSQCL SAPPFVQCGW
     CHDKCVRSEE CPSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK
     TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSITI SNGHGTTQYS TFSYVDPVIT
     SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF
     AVKLKIDLAN RETNIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLNSV SVPRMVINVH
     EAGRNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV
     FKPFEKPVMI SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL
     LKLNSELNIE WKQAISSTVL GKVIVQPDQN FTGLIAGVVS ISVALLLLLG FFLWLKKRKQ
     IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSNES VDYRATFPED QFPNSSQNGS
     CRQVQYPLTD MSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF
     NEVIGRGHFG CVYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL
     SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF
     VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF
     TTKSDVWSFG VLLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW
     HPKAEMRPSF SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SEDNADNEVD
     TRPASFWETS
//

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