(data stored in ACNUC1130 zone)

HOVERGEN: MET_NEONE

ID   MET_NEONE               Reviewed;        1382 AA.
AC   Q07E37;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   13-OCT-2009, entry version 27.
DE   RecName: Full=Hepatocyte growth factor receptor;
DE            Short=HGF receptor;
DE            EC=2.7.10.1;
DE   AltName: Full=Scatter factor receptor;
DE            Short=SF receptor;
DE   AltName: Full=HGF/SF receptor;
DE   AltName: Full=Met proto-oncogene tyrosine kinase;
DE   AltName: Full=c-Met;
DE   Flags: Precursor;
GN   Name=MET;
OS   Neofelis nebulosa (Clouded leopard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Pantherinae; Neofelis.
OX   NCBI_TaxID=61452;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Antonellis A., Ayele K., Benjamin B., Blakesley R.W., Boakye A.,
RA   Bouffard G.G., Brinkley C., Brooks S., Chu G., Coleman H., Engle J.,
RA   Gestole M., Greene A., Guan X., Gupta J., Haghighi P., Han J.,
RA   Hansen N., Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Kwong P.,
RA   Laric P., Larson S., Lee-Lin S.-Q., Legaspi R., Madden M.,
RA   Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C., Maskeri B.,
RA   McDowell J., Mojidi H.A., Mullikin J.C., Oestreicher J.S., Park M.,
RA   Portnoy M.E., Prasad A., Puri O., Reddix-Dugue N., Schandler K.,
RA   Schueler M.G., Sison C., Stantripop S., Stephen E., Taye A.,
RA   Thomas J.W., Thomas P.J., Tsipouri V., Ung L., Vogt J.L.,
RA   Wetherby K.D., Young A., Green E.D.;
RT   "NISC comparative sequencing initiative.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for hepatocyte growth factor and scatter
CC       factor. Has a tyrosine-protein kinase activity. Functions in cell
CC       proliferation, scattering, morphogenesis and survival (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC       [protein]-L-tyrosine phosphate.
CC   -!- SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta
CC       chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2.
CC       Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357,
CC       interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as
CC       well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the
CC       presence and in the absence of HGF, however HGF treatment has a
CC       positive effect on this interaction. Interacts with MUC20;
CC       prevents interaction with GRB2 and suppresses hepatocyte growth
CC       factor-induced cell proliferation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- DOMAIN: The kinase domain is involved in SPSB1 binding (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
CC   -!- SIMILARITY: Contains 3 IPT/TIG domains.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- SIMILARITY: Contains 1 Sema domain.
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CC   -!- GENE_FAMILY: HBG006348 [ FAMILY / ALN / TREE ]
DR   EMBL; DP000182; ABI93639.1; -; Genomic_DNA.
DR   SMR; Q07E37; 40-564, 1047-1347.
DR   HOVERGEN; Q07E37; -.
DR   BRENDA; 2.7.10.1; 307311.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kin...; IEA:EC.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR002909; IPT_TIG_rcpt.
DR   InterPro; IPR003659; Plexin-like.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001627; Semaphorin/CD100_Ag.
DR   InterPro; IPR001245; Tyr_pkinase.
DR   InterPro; IPR008266; Tyr_pkinase_AS.
DR   InterPro; IPR016244; TyrPK_HGF-R.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 3.
DR   PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q07E37.
DR   SWISS-2DPAGE; Q07E37.
KW   ATP-binding; Disulfide bond; Glycoprotein; Kinase; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Repeat;
KW   Signal; Transferase; Transmembrane; Tyrosine-protein kinase.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25   1382       Hepatocyte growth factor receptor.
FT                                /FTId=PRO_0000260427.
FT   TOPO_DOM     25    933       Extracellular (Potential).
FT   TRANSMEM    934    956       Potential.
FT   TOPO_DOM    957   1382       Cytoplasmic (Potential).
FT   DOMAIN       27    516       Sema.
FT   DOMAIN      564    656       IPT/TIG 1.
FT   DOMAIN      658    740       IPT/TIG 2.
FT   DOMAIN      743    837       IPT/TIG 3.
FT   DOMAIN     1079   1346       Protein kinase.
FT   NP_BIND    1085   1093       ATP (By similarity).
FT   REGION     1213   1382       Interaction with RANBP9 (By similarity).
FT   REGION     1321   1360       Interaction with MUC20 (By similarity).
FT   ACT_SITE   1205   1205       Proton acceptor (By similarity).
FT   BINDING    1111   1111       ATP (By similarity).
FT   SITE        308    309       Cleavage (Potential).
FT   MOD_RES     967    967       Phosphoserine (By similarity).
FT   MOD_RES     978    978       Phosphothreonine (By similarity).
FT   MOD_RES     989    989       Phosphoserine (By similarity).
FT   MOD_RES     991    991       Phosphoserine (By similarity).
FT   MOD_RES     998    998       Phosphoserine (By similarity).
FT   MOD_RES    1001   1001       Phosphoserine (By similarity).
FT   MOD_RES    1004   1004       Phosphotyrosine (By similarity).
FT   MOD_RES    1231   1231       Phosphotyrosine (By similarity).
FT   MOD_RES    1235   1235       Phosphotyrosine (By similarity).
FT   MOD_RES    1236   1236       Phosphotyrosine; by autocatalysis (By
FT                                similarity).
FT   MOD_RES    1357   1357       Phosphotyrosine (By similarity).
FT   CARBOHYD     45     45       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    106    106       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    203    203       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    359    359       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    400    400       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    406    406       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    608    608       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    636    636       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    786    786       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    880    880       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    931    931       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   1382 AA;  154805 MW;  BC5828ED0ED45597 CRC64;
     MKAPAVLAPG ILVLLFTLVQ KSYGECREAL VKSEMNVNMK YQLPNFTAET PIQNVVLHKH
     HIYLGAVNYI YVLNDKDLQK VAEYKTGPVL EHPDCFPCQD CSHKANLSGG VWKDNINMAL
     LIDTYYDDQL ISCGSVHRGT CQRHVLPPSN TADILSKVHC MYSPQADEES SHCPDCVVSA
     LGTKVLISEK GRFINFFVGN TINSSYLTDH SLHSISVRRL KETQDGFKFL TDQSYIDVLP
     EFRDSYPIKY IHAFESNRFI YFLTVQRETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI
     LTEKRRKRST REEVFNILQA AYVSKPGAHL AKQIGANLND DILYGVFAQS KPDSAEPMNR
     SAVCAFPIKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE
     FTTALQRVDL FMGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQVVVSR SGSSTPHVNF
     RLDSHPVSSE AIVEHPLNQN GYTLVVTGKK ITKIPLNGLG CEHFQSCSQC LSAPPFVQCG
     WCHDKCVQLE ECPSGTWTQE ICLPTIYEVF PTSAPLEGGT MLTVCGWDFG FRRNNKFDLK
     KTRVFLGNES CTLTLSESTT NMLKCTVGPA VNEHFNISII ISNGRGTAQY STFSYVDPVI
     TSIFPSYGPK TGGTLLTLTG KYLNSGNSRH ISIGGKTCTL KSVSDSILEC YTPAQTIPTE
     FPIKLKIDLA NREMNSFSYQ EDPIVYAIHP TKSFISGGST ITAVGKNLNS VSVLRMVISV
     HETRRNFTVA CHHRSNSEII CCTTPSLQQL NLQLPLKTKA FFMLDGIHSK YFDLIYVHNP
     VFKPFEKPVM ISIGNENVLE IKGNDIDPEA VKGEVLKVGN KSCETIYSDS EAVLCKVPND
     LLKLNNELNI EWKQAVSSTI LGKVIVQPDQ NFTGLIVGVI SISIILLLLL GVFLWLKKRK
     QIKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG
     SCRQVQYPLT DLSPMLNSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH
     FNEVIGRGHF GCVYHGTLLD SDDKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV
     LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK
     FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK
     FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DPLYEVMLKC
     WHPKAELRPS FSELVSRISA IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNIDGEG
     DT
//

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