(data stored in ACNUC1130 zone)

HOVERGEN: MET_PIG

ID   MET_PIG                 Reviewed;        1381 AA.
AC   Q2QLE0; Q2VHX7;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   13-OCT-2009, entry version 38.
DE   RecName: Full=Hepatocyte growth factor receptor;
DE            Short=HGF receptor;
DE            EC=2.7.10.1;
DE   AltName: Full=Scatter factor receptor;
DE            Short=SF receptor;
DE   AltName: Full=HGF/SF receptor;
DE   AltName: Full=Met proto-oncogene tyrosine kinase;
DE   AltName: Full=c-Met;
DE   Flags: Precursor;
GN   Name=MET;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hwang K.C., Kwon D.N., Kang S.J., Kim C.U., Choi Y.J., Lee S.Y.,
RA   Kim J.H.;
RT   "Identification and characterization of differentially expressed gene
RT   in porcine placenta.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22799194; PubMed=12917688; DOI=10.1038/nature01858;
RA   Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G.,
RA   Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C.,
RA   Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S.,
RA   Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R.,
RA   Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B.,
RA   Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E.,
RA   Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K.,
RA   Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J.,
RA   Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R.,
RA   Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C.,
RA   Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C.,
RA   Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C.,
RA   Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J.,
RA   Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P.,
RA   Miller W., Green E.D.;
RT   "Comparative analyses of multi-species sequences from targeted genomic
RT   regions.";
RL   Nature 424:788-793(2003).
CC   -!- FUNCTION: Receptor for hepatocyte growth factor and scatter
CC       factor. Has a tyrosine-protein kinase activity. Functions in cell
CC       proliferation, scattering, morphogenesis and survival (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC       [protein]-L-tyrosine phosphate.
CC   -!- SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta
CC       chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2.
CC       Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356,
CC       interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as
CC       well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the
CC       presence and in the absence of HGF, however HGF treatment has a
CC       positive effect on this interaction. Interacts with MUC20;
CC       prevents interaction with GRB2 and suppresses hepatocyte growth
CC       factor-induced cell proliferation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- DOMAIN: The kinase domain is involved in SPSB1 binding (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
CC   -!- SIMILARITY: Contains 3 IPT/TIG domains.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- SIMILARITY: Contains 1 Sema domain.
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CC   -!- GENE_FAMILY: HBG006348 [ FAMILY / ALN / TREE ]
DR   EMBL; DQ141604; AAZ94040.1; -; mRNA.
DR   EMBL; DP000017; AAR16301.1; -; Genomic_DNA.
DR   RefSeq; NP_001033097.1; -.
DR   UniGene; Ssc.42717; -.
DR   SMR; Q2QLE0; 40-563, 1046-1346.
DR   GeneID; 654328; -.
DR   KEGG; ssc:654328; -.
DR   CTD; 654328; -.
DR   HOVERGEN; Q2QLE0; -.
DR   BRENDA; 2.7.10.1; 249.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kin...; IEA:EC.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR002909; IPT_TIG_rcpt.
DR   InterPro; IPR003659; Plexin-like.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001627; Semaphorin/CD100_Ag.
DR   InterPro; IPR001245; Tyr_pkinase.
DR   InterPro; IPR008266; Tyr_pkinase_AS.
DR   InterPro; IPR016244; TyrPK_HGF-R.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 3.
DR   PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q2QLE0.
DR   SWISS-2DPAGE; Q2QLE0.
KW   ATP-binding; Disulfide bond; Glycoprotein; Kinase; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Repeat;
KW   Signal; Transferase; Transmembrane; Tyrosine-protein kinase.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25   1381       Hepatocyte growth factor receptor.
FT                                /FTId=PRO_0000226365.
FT   TOPO_DOM     25    932       Extracellular (Potential).
FT   TRANSMEM    933    955       Potential.
FT   TOPO_DOM    956   1381       Cytoplasmic (Potential).
FT   DOMAIN       27    515       Sema.
FT   DOMAIN      563    655       IPT/TIG 1.
FT   DOMAIN      657    739       IPT/TIG 2.
FT   DOMAIN      742    836       IPT/TIG 3.
FT   DOMAIN     1078   1345       Protein kinase.
FT   NP_BIND    1084   1092       ATP (By similarity).
FT   REGION     1212   1381       Interaction with RANBP9 (By similarity).
FT   REGION     1320   1359       Interaction with MUC20 (By similarity).
FT   ACT_SITE   1204   1204       Proton acceptor (By similarity).
FT   BINDING    1110   1110       ATP (By similarity).
FT   SITE        308    309       Cleavage (Potential).
FT   MOD_RES     966    966       Phosphoserine (By similarity).
FT   MOD_RES     977    977       Phosphothreonine (By similarity).
FT   MOD_RES     988    988       Phosphoserine (By similarity).
FT   MOD_RES     990    990       Phosphoserine (By similarity).
FT   MOD_RES     997    997       Phosphoserine (By similarity).
FT   MOD_RES    1003   1003       Phosphotyrosine (By similarity).
FT   MOD_RES    1230   1230       Phosphotyrosine (By similarity).
FT   MOD_RES    1234   1234       Phosphotyrosine (By similarity).
FT   MOD_RES    1235   1235       Phosphotyrosine; by autocatalysis (By
FT                                similarity).
FT   MOD_RES    1356   1356       Phosphotyrosine (By similarity).
FT   CARBOHYD     45     45       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    106    106       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    203    203       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    359    359       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    400    400       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    406    406       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    607    607       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    635    635       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    785    785       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    879    879       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    930    930       N-linked (GlcNAc...) (Potential).
FT   CONFLICT    706    706       I -> V (in Ref. 1; AAZ94040).
FT   CONFLICT    793    793       R -> H (in Ref. 1; AAZ94040).
SQ   SEQUENCE   1381 AA;  154748 MW;  B63EB5584757468F CRC64;
     MKAPAVLAPG ILVLLFTLVQ KSKGECKEAL VKSTMNLNMQ YQLPNFTAET PIQNVVLHKH
     HIYLGALNYI YVLNDIDLRK VAEYKTGPVL EHPDCFPCQD CSHKANLSGG IWRDNINMAL
     LVDTYYDDQL ISCGSVHRGT CQRHVLPPDN IADIKSEVHC MYSPQVDEEP SQCPDCVVSA
     LGTKVLLSEK DRFINFFVGN TINSSYLPDH SLHSISVRRL KETQDGFKFL TDQSYIDVLP
     EFRDSYPIKY VHAFESNHFI YFLTVQRETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI
     LTEKRRKRST REEVFNILQA AYVSKPGTQL AKQIGANLND DILYGVFAQS KPDSAEPMNR
     SAVCAFPVKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE
     FTTALQRIDL FMGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQVVVSR PGLSTPHVNF
     HLDSHPVSPE VIVEPLNQNG YTLVVTGKKI TKIPLNGLGC EHFQSCSQCL SAPPFVQCGW
     CQDKCVQLEE CPSGTWTQEI CLPTVYKVFP TSAPLEGGTT LTICGWDFGF RRNNKFDLRK
     TKVLLGNESC TLTLSESTTN TLKCTVGPAM NEHFNMSIVI SNGRGTTQYR TFSYVDPVIT
     NISPSFGPKT GGTLLTLTGM HLNSGNSRHI SIGGKTCTLK SVSDSILECY TPAQTTPTEF
     PIKLKIDLAN REINSFTYRE DPIVYEIHPT KSFISGGSTI TGVGRNLNSV SVLRMVINVH
     EAERNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGIHSKY FDLIYVHNPV
     FKPFEKPVMI SIGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHSHSE AVLCTVPNDL
     LKLNSELNIE WKQAISSTVL GKVIVQPDQN FTGLIVGVVS ISIILLLLLG LFLWLKKRKQ
     IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSSEP VDYRATFPED QFPNSSQNGS
     CRQVQYPLTD LSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF
     NEVIGRGHFG CVYHGTLLDN DDKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL
     SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF
     VHRDLAARNC MLDEKFTVKV ADFGLARDVY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF
     TTKSDVWSFG VLLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW
     HPRAELRPSF SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SQDNVDGEGD
     T
//

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