(data stored in SCRATCH3701 zone)

HOGENOM6: MICAI_1_PE10

ID   MICAI_1_PE10                         STANDARD;      PRT;   1259 AA.
AC   MICAI_1_PE10; D9T2Z6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (MICAI_1.PE10).
GN   OrderedLocusNames=Micau_0010;
OS   MICROMONOSPORA AURANTIACA ATCC 27029.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micromonosporineae; Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=644283;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MICAI_1.PE10.
CC       Micromonospora aurantiaca ATCC 27029 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:D9T2Z6_MICAI
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D9T2Z6; -.
DR   EMBL; CP002162; ADL43579.1; -; Genomic_DNA.
DR   RefSeq; YP_003833155.1; NC_014391.1.
DR   GeneID; 9598065; -.
DR   GenomeReviews; CP002162_GR; Micau_0010.
DR   KEGG; mau:Micau_0010; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR003586; Hedgehog_hint_C.
DR   InterPro; IPR003587; Hedgehog_hint_N.
DR   InterPro; IPR006142; INTEIN.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR006141; Intein_splice_site.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 2.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 2.
DR   PRINTS; PR00379; INTEIN.
DR   SMART; SM00305; HintC; 1.
DR   SMART; SM00306; HintN; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 2.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   TIGRFAMs; TIGR01443; Intein_Cterm; 1.
DR   TIGRFAMs; TIGR01445; Intein_Nterm; 1.
DR   PROSITE; PS50818; INTEIN_C_TER; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS50817; INTEIN_N_TER; 1.
DR   HOGENOMDNA; MICAI_1.PE10; -.
DR   PRODOM; MICAI_1_PE10.
DR   SWISS-2DPAGE; MICAI_1_PE10.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   1259 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDTPESTPN EPETPEPLAA VVQHDRIEPV GLEVEMQRSY LDYAMSVIVG RALPDVRDGL
     KPVHRKILYA MFDSGYRPDR GYVKCSRVVG DVMGQFHPHG DSAIYDALVR MAQPWSLRYP
     LVDGNGNFGS PGNDPAAAMR YCLAADVRVR TVDGTVRIGD VVPDAAPSSE TDVDLKVRDR
     NGDLVRASRF FHSGEHPTLR LRTREGYELT GTHNHPVLCL VNVAGVPTLL WKLLAEIAPG
     DRVALQRTVP DEIGYPMLEH VEAAVLAGAL VSEGWVSEQR AGFNNVDREF FVRVLTAYDL
     AVGGPRYVAE RVIDSGSTLH ELDVQNLAAL RASVLGEMVG ARSADKFVPE FVWRGPAAVK
     RAFLQALFEG DGSSSLLPRR TIQVSYSTRS ERLAREVQQL LLEFGVVSRQ CRYDDGEIKV
     VVTNRRDARI FAAHVGFLGR KQAKLESELA QVPASSTALS GDHVPFVGDF VREHGASRWT
     ERDWLRRHNV DRIERWERDR DEIAARITEP GILDVVEPLV DGRFYYAEVT DVTDAGVQPV
     YSIRVDTEDH SFVSDGFVSH NTECKLDPLA MEMLRDIDED TVDLQDNYDG RAKEPTILPS
     RIPNLLINGS EGIAVGMATK IPPHNLREIG AAVQWCLEHP EADEATTLEA LLEIVKGPDF
     PTHGLIVGQA GIQDAYRTGR GSIRMRAVVE VEEDKRGRPA LVVSELPYQV NPDNLAERIA
     ELIKEGKLAG IADIRDESSG RTGMRIVLVL KRDAVAKVVL NNLYKHTQLQ ETFGANMLAL
     VDGVPRTLNL AQFIRYYVEH QIEVIRRRTA FRLRKAEERA HILRGLSKAL DALDEVIALI
     RRSPTVEDAR QGLIRLLDID EVQATAILDM QLRRLAALER QRILDDLAKL EVEIADLKDI
     LAKPERQRRI VSEELGEIVA KWGDDRRTKI VPFDGEVSME DLIAREDVVV TITRTGYAKR
     TKVDLYRSQR RGGKGVSGAT LRQDDIVSHF FVCSTHDWIL FFTNKGRVYR AKAYELPEAS
     RVAKGQHVAN LLAFQPDEQI AQIIEIPNYQ VAPYLVLATK NGLVKKTRLE EFDSNRSGGI
     IAINLRDEDE LVGAVLVAPE DDLLLVSKNA QAIRFNATDE ALRPMGRATS GVIGMRFSGE
     DELLAVEVVR EGLDVLVATN GGYAKRTPIE EYPVQGRGGK GVLTAKITER RGGLVGAVVI
     DPEDELFAIT SNGGVIRTPV KPVRRTRDRN TMGVKLMDLP DGVTIVAIAR NADEPDEQD
//

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