(data stored in ACNUC7421 zone)

HOGENOM: MITES1_1_PE1002

ID   MITES1_1_PE1002                      STANDARD;      PRT;   258 AA.
AC   MITES1_1_PE1002; E8NFS1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Formamidopyrimidine-DNA glycosylase; EC=3.2.2 23;
DE   (MITES1_1.PE1002).
GN   OrderedLocusNames=MTES_1002;
OS   MICROBACTERIUM TESTACEUM STLB037.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Microbacteriaceae; Microbacterium.
OX   NCBI_TaxID=979556;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MITES1_1.PE1002.
CC       Microbacterium testaceum StLB037, complete genome.
CC       1..405839 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:E8NFS1_MICTS
CC   -!- FUNCTION: Involved in base excision repair of DNA damaged by
CC       oxidation or by mutagenic agents (By similarity).
CC   -!- CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or
CC       apyrimidinic site in DNA is broken by a beta-elimination reaction,
CC       leaving a 3'-terminal unsaturated sugar and a product with a
CC       terminal 5'-phosphate.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SIMILARITY: Belongs to the FPG family.
CC   -!- SIMILARITY: Contains 1 FPG-type zinc finger.
CC   -!- GENE_FAMILY: HOG000020880 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E8NFS1; -.
DR   EMBL; AP012052; BAJ73966.1; -; Genomic_DNA.
DR   RefSeq; YP_004223846.1; NC_015125.1.
DR   GeneID; 10217906; -.
DR   GenomeReviews; AP012052_GR; MTES_1002.
DR   KEGG; mts:MTES_1002; -.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0008534; F:oxidized purine base lesion DNA N-glycosylase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   InterPro; IPR015886; DNA_glyclase/AP_lyase_DNA-bd.
DR   InterPro; IPR012319; DNA_glycosylase/AP_lyase_cat.
DR   InterPro; IPR010979; Ribosomal_S13-like_H2TH.
DR   InterPro; IPR000214; Znf_DNA_glyclase/AP_lyase.
DR   InterPro; IPR010663; Znf_DNA_glyclase/IsotRNA_synth.
DR   Pfam; PF01149; Fapy_DNA_glyco; 1.
DR   Pfam; PF06831; H2TH; 1.
DR   Pfam; PF06827; zf-FPG_IleRS; 1.
DR   SMART; SM00898; Fapy_DNA_glyco; 1.
DR   SUPFAM; SSF81624; Form_DNAglyc_cat; 1.
DR   SUPFAM; SSF46946; Ribosomal_H2TH; 1.
DR   PROSITE; PS51068; FPG_CAT; 1.
DR   PROSITE; PS51066; ZF_FPG_2; 1.
DR   HOGENOMDNA; MITES1_1.PE1002; -.
KW   formamidopyrimidine-DNA glycosylase;
KW   Complete proteome; DNA damage; DNA repair; DNA-binding; Glycosidase;
KW   Hydrolase; Lyase; Metal-binding; Multifunctional enzyme; Zinc;
KW   Zinc-finger.
SQ   SEQUENCE   258 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPEGDTVYRA AAKLSAALAG KVVTRFDIRV PGSATADLRG ETVHEVAARG KHLLHRIGGY
     TLHSHLKMEG RWDVYRPGER WRRPAFKARA IVGVAGADAV GFDLAMVEVL RTTDEHTVIG
     HLGPDLLADD WDEAEAVRRV GADTREVHVA LLDQRNVAGF GNVYANELLF VRGIAPTTPA
     TEIDVPATIA LGERMIRANL PRPERTFTGD TRPGRRFWVY GREGAPCRRC GTPIRATALG
     ASATSERNVY WCPTCQPG
//

If you have problems or comments...

PBIL Back to PBIL home page