(data stored in SCRATCH3701 zone)

HOGENOM6: MITES1_1_PE1503

ID   MITES1_1_PE1503                      STANDARD;      PRT;   876 AA.
AC   MITES1_1_PE1503; E8N931;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=Type IIA topoisomerase (MITES1_1.PE1503) (DNA gyrase/topo
DE   II, topoisomerase IV), A subunit; .
GN   Name=gyrA; OrderedLocusNames=MTES_1503;
OS   MICROBACTERIUM TESTACEUM STLB037.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Microbacteriaceae; Microbacterium.
OX   NCBI_TaxID=979556;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MITES1_1.PE1503.
CC       Microbacterium testaceum StLB037, complete genome.
CC       1..405839 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:E8N931_MICTS
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E8N931; -.
DR   EMBL; AP012052; BAJ74467.1; -; Genomic_DNA.
DR   RefSeq; YP_004224347.1; NC_015125.1.
DR   GeneID; 10218359; -.
DR   GenomeReviews; AP012052_GR; MTES_1503.
DR   KEGG; mts:MTES_1503; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; MITES1_1.PE1503; -.
DR   PRODOM; MITES1_1_PE1503.
DR   SWISS-2DPAGE; MITES1_1_PE1503.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   876 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MADDITPEPD EVRSEPAHNH GRIDQVDLQL EMQRSYLDYA MSVIVGRALP RVEDGLKPVH
     RRVIYGMYDG GFRPDKSFSK CARVVGEVMG HYHPHGDAPI YDALVRLVQP WSLRYPLALG
     QGNFGSPGNQ GAAAPRYTET KMSQLALEMV RDIEEETVDF EDNYDGQTQE PVVLPSRFPN
     LLVNGSVGIA VGMATNIPPH NLREVSAGAL WALENPDATR EELLEALMER IPGPDFPTAA
     QILGTRGIKD AYRTGRGSIT MRAVVNIEEI QGRTCLVITE LPYQVNPDNV AVKIGDLARE
     GKITGIADIR DETSGRTGQR LVVVLKRDAV AKVVLNNLYK HTQLQENFGA NMLAIVDGVP
     RTLSLDGFVS HWIDHQVNVI VRRTRYRLRK AEERMHILRG YLKALDALDE VIALIRRSPT
     AQDANEGLQK LLDIDDIQAQ AILDMQLRRL AALERQKIVD EATELEARIA DFNDILASPA
     RQRTIIRDEL TGIVDRFGDD RRTQILHGFD GDVSIEDLIA EEEMVITVTR DGYIKRTRSD
     NYRSQHRGGK GVKGAQLRAD DVVEHFFVTT THHWLLFFTN KGRVYRSKAY EVPEAGRDAK
     GQHVANLLAL QPDEEIAQIL DIRDYSVATY LVLATRNGLV KKTRLDEYDT NRQGGVIAIK
     LRGQVSDEAD ETEQGGADEL VSALLVDEGD DILLISRLGM SLRFSATDNA LRPMGRSTSG
     VKGMDFREGD SLLSASVAKD DEFVFVVTEG GYAKRTAVTE YRMQNRGGLG IKVARLTDDR
     GVLAGGMMVS EGDEVLVVLA SGKVVRSAVA EVPAKGRDTM GVVFARAGGD DRIIAIARNA
     ERNLAETTET TTEPAAVPAD EADASAPETP EESTDA
//

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