(data stored in ACNUC13530 zone)

HOVERGEN: MK09_CHICK

ID   MK09_CHICK              Reviewed;         382 AA.
AC   P79996;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-NOV-2009, entry version 75.
DE   RecName: Full=Mitogen-activated protein kinase 9;
DE            EC=2.7.11.24;
DE   AltName: Full=Stress-activated protein kinase JNK2;
DE            Short=c-Jun N-terminal kinase 2;
GN   Name=MAPK9; Synonyms=JNK2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Embryo;
RX   MEDLINE=97320448; PubMed=9177299; DOI=10.1006/bbrc.1997.6140;
RA   Ishikawa T., Nakada-Moriya Y., Ando C., Tanda N., Nishida S.,
RA   Minatogawa Y., Nohno T.;
RT   "Expression of the JNK2-alpha1 gene in the developing chick brain.";
RL   Biochem. Biophys. Res. Commun. 234:489-492(1997).
RN   [2]
RP   ERRATUM.
RA   Ishikawa T., Nakada-Moriya Y., Ando C., Tanda N., Nishida S.,
RA   Minatogawa Y., Nohno T.;
RL   Biochem. Biophys. Res. Commun. 236:538-538(1997).
CC   -!- FUNCTION: Responds to activation by environmental stress and pro-
CC       inflammatory cytokines by phosphorylating a number of
CC       transcription factors, primarily components of AP-1 such as c-Jun
CC       and ATF2 and thus regulates AP-1 transcriptional activity (By
CC       similarity). May play a role in the development of the central
CC       nervous system during embryogenesis.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- ENZYME REGULATION: Activated by threonine and tyrosine
CC       phosphorylation (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in the neuroepithelium of developing
CC       brain at stages 16 to 26.
CC   -!- DOMAIN: The TXY motif contains the threonine and tyrosine residues
CC       whose phosphorylation activates the MAP kinases.
CC   -!- PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates
CC       the enzyme (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
CC       Ser/Thr protein kinase family. MAP kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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CC   -!- GENE_FAMILY: HBG014652 [ FAMILY / ALN / TREE ]
DR   EMBL; AB000807; BAA19188.1; -; mRNA.
DR   IPI; IPI00587799; -.
DR   PIR; JC5531; JC5531.
DR   RefSeq; NP_990426.1; -.
DR   UniGene; Gga.43959; -.
DR   HSSP; P53779; 1JNK.
DR   SMR; P79996; 7-364.
DR   STRING; P79996; -.
DR   Ensembl; ENSGALT00000022353; ENSGALP00000022313; ENSGALG00000013761; Gallus gallus.
DR   GeneID; 395983; -.
DR   KEGG; gga:395983; -.
DR   CTD; 395983; -.
DR   HOGENOM; P79996; -.
DR   HOVERGEN; P79996; -.
DR   OMA; NGVVKDQ; -.
DR   BRENDA; 2.7.11.24; 4.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004707; F:MAP kinase activity; IEA:EC.
DR   GO; GO:0009790; P:embryonic development; IDA:UniProtKB.
DR   GO; GO:0007254; P:JNK cascade; ISS:UniProtKB.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR008351; JNK_MAPK.
DR   InterPro; IPR003527; MAP_kinase_CS.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR01772; JNKMAPKINASE.
DR   ProDom; PD000001; Prot_kinase; 2.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS01351; MAPK; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; P79996.
DR   SWISS-2DPAGE; P79996.
KW   ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Serine/threonine-protein kinase; Transferase.
FT   DOMAIN       29    221       PRODOM:2005.1:PD000001  8496
FT   DOMAIN      253    295       PRODOM:2005.1:PD904258  25
FT   DOMAIN      326    360       PRODOM:2005.1:PD729355  109
FT   CHAIN         1    382       Mitogen-activated protein kinase 9.
FT                                /FTId=PRO_0000186276.
FT   DOMAIN       26    321       Protein kinase.
FT   NP_BIND      33     38       ATP (By similarity).
FT   MOTIF       183    185       TXY.
FT   ACT_SITE    151    151       Proton acceptor (By similarity).
FT   BINDING      55     55       ATP (By similarity).
FT   MOD_RES     183    183       Phosphothreonine (By similarity).
FT   MOD_RES     185    185       Phosphotyrosine (By similarity).
SQ   SEQUENCE   382 AA;  44009 MW;  9A737C925465E54C CRC64;
     MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI NVAVKKLSRP
     FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKSLEE FQDVYLVMEL MDANLCQVIH
     MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF
     MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ
     LGTPSAEFMK KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESDRDKLK TSQARDLLSK
     MLVVDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE EWKELIYKEV
     MDWEERSKNG VVKDQPSAQM QQ
//

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