(data stored in ACNUC8465 zone)

HOGENOM: MOUSE10_PE1353

ID   MOUSE10_PE1353                       STANDARD;      PRT;   401 AA.
AC   MOUSE10_PE1353; Q63932; Q9D7B0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 2;
DE   Short=MAP kinase kinase 2; Short=MAPKK 2; EC=2.7.12 2;AltName: Full=ERK
DE   activator kinase 2;AltName: Full=MAPK/ERK kinase 2; Short=MEK 2;
DE   (MOUSE10.PE1353).
GN   Name=Map2k2; Synonyms=Mek2, Mkk2, Prkmk2;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE10.PE1353.
CC       Mus musculus chromosome 10 NCBIM37  sequence 1..129993255 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K2_MOUSE
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP
CC       kinases. Activates the ERK1 and ERK2 MAP kinases.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Inhibited by serine/threonine phosphatase 2A.
CC   -!- SUBUNIT: Interacts with MORG1.
CC   -!- TISSUE SPECIFICITY: Expressed in adult intestine, kidney, liver,
CC       lung, pancreas, spleen, thymus, and at high levels in the neonatal
CC       brain. Lower expression is found in adult brain and heart.
CC   -!- PTM: Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF
CC       or MEKK1) regulates positively the kinase activity. Low levels of
CC       autophosphorylation have been observed.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000035027;ENSMUST00000143517;ENSMUSP00000121111.
DR   EMBL; AC155932; - ;
DR   EMBL; AK009392; - ;
DR   EMBL; AK036822; - ;
DR   EMBL; AK080574; - ;
DR   EMBL; AK140101; - ;
DR   EMBL; CH466553; - ;
DR   EMBL; S68267; - ;
DR   UniProtKB/Swiss-Prot; Q63932; Q9D7B0; -.
DR   EMBL; S68267; AAC60678.1; -; mRNA.
DR   EMBL; AK009392; BAB26261.1; -; mRNA.
DR   EMBL; AK080574; BAC37945.1; -; mRNA.
DR   EMBL; CH466553; EDL31456.1; -; Genomic_DNA.
DR   IPI; IPI00135708; -.
DR   RefSeq; NP_075627.2; NM_023138.4.
DR   UniGene; Mm.275436; -.
DR   ProteinModelPortal; Q63932; -.
DR   DIP; DIP-454N; -.
DR   IntAct; Q63932; 3.
DR   MINT; MINT-1518275; -.
DR   STRING; Q63932; -.
DR   PhosphoSite; Q63932; -.
DR   PRIDE; Q63932; -.
DR   Ensembl; ENSMUST00000143517; ENSMUSP00000121111; ENSMUSG00000035027.
DR   GeneID; 26396; -.
DR   CTD; 5605; -.
DR   MGI; MGI:1346867; Map2k2.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q63932; -.
DR   OrthoDB; EOG4SF965; -.
DR   PhylomeDB; Q63932; -.
DR   BRENDA; 2.7.12.2; 3474.
DR   ArrayExpress; Q63932; -.
DR   Bgee; Q63932; -.
DR   CleanEx; MM_MAP2K2; -.
DR   Genevestigator; Q63932; -.
DR   GermOnline; ENSMUSG00000035027; Mus musculus.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0032947; F:protein complex scaffold; IDA:BHF-UCL.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:2000147; P:positive regulation of cell motility; IDA:BHF-UCL.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; MOUSE10.PE1353; -.
KW   ENSMUSG000000350275old_1320000031; ENSMUSP000001211111old_1320000031;
KW   D3Z446_MOUSE; Q3USU3_MOUSE; Q8CB46_MOUSE; Q9D7B0_MOUSE; AC155932;
KW   AK036822; AK080574; AK140101; CH466553; S68267;
KW   Acetylation; ATP-binding; Complete proteome;
KW   Direct protein sequencing; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase;
KW   Tyrosine-protein kinase.
SQ   SEQUENCE   401 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLARRKPVLP ALTINPTIAE GPSPTSEGAS EANLVDLQKK LEELDLDEQQ RKRLEAFLTQ
     KAKVGELKDD DFERISELGA GNGGVVTKAR HRPSGLIMAR KLIHLEIKPA VRNQIIRELQ
     VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEDIL GKVSIAVLRG
     LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ
     GTHYSVQSDI WSMGLSLVEL AIGRYPIPPP DAKELEASFG RPVVDGADGE PHSVSPRPRP
     PGRPISVGHG MDSRPAMAIF ELLDYIVNEP PPKLPSGVFS SDFQEFVNKC LIKNPAERAD
     LKLLMNHAFI KRSEGEEVDF AGWLCRTLRL KQPSTPTRTA V
//

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