(data stored in ACNUC9435 zone)

HOGENOM: MOUSE10_PE826

ID   MOUSE10_PE826                        STANDARD;      PRT;   420 AA.
AC   MOUSE10_PE826; P08152;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Early growth response protein 2; Short=EGR-2;AltName:
DE   Full=Zinc finger protein Krox-20; (MOUSE10.PE826).
GN   Name=Egr2; Synonyms=Egr-2, Krox-20, Zfp-25;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE10.PE826.
CC       Mus musculus chromosome 10 NCBIM37  sequence 1..129993255 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:EGR2_MOUSE
CC   -!- FUNCTION: Sequence-specific DNA-binding transcription factor.
CC       Binds to two specific DNA sites located in the promoter region of
CC       HOXA4. Binds to the promoter region of ERBB2. May play a role in
CC       the regulation of hindbrain segmentation, might act in combination
CC       with the Hox network to specify odd and even rhombomeres, and
CC       might participate in the control of the expression of some of the
CC       homeobox containing genes.
CC   -!- SUBUNIT: Interacts with HCFC1 (By similarity). Interacts with
CC       WWP2. Interacts with CITED1. Interacts (via phosphorylated form)
CC       with SFN.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P08152-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=P08152-2; Sequence=VSP_006864;
CC   -!- TISSUE SPECIFICITY: Expressed in mammary tumors (at protein
CC       level). Expressed mainly in adult thymus and embryonic nervous
CC       system.
CC   -!- INDUCTION: Activated during G0/G1 transition in cultured cells.
CC   -!- PTM: Ubiquitinated by WWP2 leading to proteasomal degradation.
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC   -!- GENE_FAMILY: HOG000036856 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000037868;ENSMUST00000105438;ENSMUSP00000101078.
DR   EMBL; AC153379; - ;
DR   EMBL; BC009093; - ;
DR   EMBL; M20759; - ;
DR   EMBL; M24376; - ;
DR   EMBL; M24377; - ;
DR   EMBL; X06746; - ;
DR   UniProtKB/Swiss-Prot; P08152; -.
DR   EMBL; M24377; AAA39379.1; -; Genomic_DNA.
DR   EMBL; M24376; AAA39379.1; JOINED; Genomic_DNA.
DR   EMBL; M24377; AAA39380.1; -; Genomic_DNA.
DR   EMBL; M24376; AAA39380.1; JOINED; Genomic_DNA.
DR   EMBL; X06746; CAA29921.1; -; mRNA.
DR   EMBL; BC009093; AAH09093.1; -; mRNA.
DR   EMBL; M20759; AAA39381.1; -; Genomic_DNA.
DR   IPI; IPI00129741; -.
DR   IPI; IPI00221598; -.
DR   PIR; A30136; A30136.
DR   PIR; S00256; S00256.
DR   RefSeq; NP_034248.2; NM_010118.3.
DR   UniGene; Mm.290421; -.
DR   ProteinModelPortal; P08152; -.
DR   SMR; P08152; 246-457.
DR   MINT; MINT-2828823; -.
DR   STRING; P08152; -.
DR   PhosphoSite; P08152; -.
DR   PRIDE; P08152; -.
DR   Ensembl; ENSMUST00000048289; ENSMUSP00000041053; ENSMUSG00000037868.
DR   Ensembl; ENSMUST00000105438; ENSMUSP00000101078; ENSMUSG00000037868.
DR   Ensembl; ENSMUST00000169930; ENSMUSP00000128297; ENSMUSG00000037868.
DR   GeneID; 13654; -.
DR   KEGG; mmu:13654; -.
DR   CTD; 1959; -.
DR   MGI; MGI:95296; Egr2.
DR   eggNOG; roNOG05743; -.
DR   GeneTree; ENSGT00550000074455; -.
DR   InParanoid; P08152; -.
DR   OMA; GNEGPRL; -.
DR   OrthoDB; EOG41NTMJ; -.
DR   PhylomeDB; P08152; -.
DR   NextBio; 284388; -.
DR   ArrayExpress; P08152; -.
DR   Bgee; P08152; -.
DR   CleanEx; MM_EGR2; -.
DR   Genevestigator; P08152; -.
DR   GermOnline; ENSMUSG00000037868; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IDA:UniProtKB.
DR   GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IPI:BHF-UCL.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0035284; P:brain segmentation; IMP:MGI.
DR   GO; GO:0021612; P:facial nerve structural organization; IGI:MGI.
DR   GO; GO:0045444; P:fat cell differentiation; IMP:BHF-UCL.
DR   GO; GO:0008045; P:motor axon guidance; IGI:MGI.
DR   GO; GO:0042552; P:myelination; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
DR   GO; GO:0006611; P:protein export from nucleus; IDA:UniProtKB.
DR   GO; GO:0030278; P:regulation of ossification; IMP:MGI.
DR   GO; GO:0021660; P:rhombomere 3 formation; IMP:MGI.
DR   GO; GO:0021666; P:rhombomere 5 formation; IMP:MGI.
DR   GO; GO:0007622; P:rhythmic behavior; IDA:MGI.
DR   GO; GO:0014037; P:Schwann cell differentiation; IMP:MGI.
DR   GO; GO:0006366; P:transcription from RNA polymerase II promoter; IDA:BHF-UCL.
DR   InterPro; IPR021849; DUF3446.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
DR   Pfam; PF11928; DUF3446; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR   HOGENOMDNA; MOUSE10.PE826; -.
KW   ENSMUSG000000378685old_1320000031; ENSMUSP000001010781old_1320000031;
KW   D3YXS2_MOUSE; D3Z3K7_MOUSE; AC153379; BC009093; M20759; M24376; M24377;
KW   X06746;
KW   Activator; Alternative splicing; Complete proteome; DNA-binding;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
SQ   SEQUENCE   420 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNGVAGDGMI NIDMTGEKRP LDLPYPSSFA PISAPRNQTF TYMGKFSIDP QYPGASCYPE
     GIINIVSAGI LQGVTPPAST TASSSVTSAS PNPLATGPLG VCTMSQTQPE LDHLYSPPPP
     PPPYSGCTGD LYQDPSAFLS PPSTTSTSSL AYQPPPSYPS PKPAMDPGLI PMIPDYPGFF
     PSPCQRDPHG AAGPDRKPFP CPLDSLRVPP PLTPLSTIRN FTLGGPGAGV TGPGASGGGE
     GPRLPGSGSA AVTATPYNPH HLPLRPILRP RKYPNRPSKT PVHERPYPCP AEGCDRRFSR
     SDELTRHIRI HTGHKPFQCR ICMRNFSRSD HLTTHIRTHT GEKPFACDYC GRKFARSDER
     KRHTKIHLRQ KERKSSAPSA PPSAQSSASG PGGSQAGGSL CGNSAIGGPL ASCTSRTRTP
//

If you have problems or comments...

PBIL Back to PBIL home page