(data stored in ACNUC8465 zone)

HOGENOM: MOUSE11_PE1363

ID   MOUSE11_PE1363                       STANDARD;      PRT;   347 AA.
AC   MOUSE11_PE1363; O09110; P97293; Q91VX1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 3;
DE   Short=MAP kinase kinase 3; Short=MAPKK 3; EC=2.7.12 2;AltName:
DE   Full=MAPK/ERK kinase 3; Short=MEK 3; (MOUSE11.PE1363).
GN   Name=Map2k3; Synonyms=Mkk3, Prkmk3;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE11.PE1363.
CC       Mus musculus chromosome 11 NCBIM37  sequence 1..121843856 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K3_MOUSE
CC   -!- FUNCTION: Dual specificity kinase. Is activated by cytokines and
CC       environmental stress in vivo. Catalyzes the concomitant
CC       phosphorylation of a threonine and a tyrosine residue in the MAP
CC       kinase p38 (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated by dual phosphorylation on Ser-218
CC       and Thr-222 (By similarity).
CC   -!- SUBUNIT: Binds to DYRK1B/MIRK and increases its kinase activity
CC       (By similarity). Part of a complex with MAP3K3, RAC1 and CCM2.
CC       Interacts with ARRB1 (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=2; Synonyms=3b;
CC         IsoId=O09110-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=O09110-2; Sequence=VSP_004879;
CC   -!- PTM: Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase
CC       kinases regulates positively the kinase activity. Phosphorylated
CC       by TAOK2 (By similarity). Autophosphorylated.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000018932;ENSMUST00000019076;ENSMUSP00000019076.
DR   EMBL; AK008141; - ;
DR   EMBL; AK011002; - ;
DR   EMBL; AK150067; - ;
DR   EMBL; AK159379; - ;
DR   EMBL; AK166255; - ;
DR   EMBL; AK166507; - ;
DR   EMBL; AK167209; - ;
DR   EMBL; AK167442; - ;
DR   EMBL; AK168710; - ;
DR   EMBL; AL603830; - ;
DR   EMBL; BC007467; - ;
DR   EMBL; D87115; - ;
DR   EMBL; X93150; - ;
DR   UniProtKB/Swiss-Prot; O09110; P97293; Q91VX1; -.
DR   EMBL; X93150; CAA63649.1; -; mRNA.
DR   EMBL; D87115; BAA13247.1; -; mRNA.
DR   EMBL; AK011002; BAB27321.1; -; mRNA.
DR   EMBL; AK008141; BAB25489.1; -; mRNA.
DR   EMBL; BC007467; AAH07467.1; -; mRNA.
DR   IPI; IPI00114245; -.
DR   IPI; IPI00230052; -.
DR   RefSeq; NP_032954.1; NM_008928.4.
DR   UniGene; Mm.18494; -.
DR   ProteinModelPortal; O09110; -.
DR   SMR; O09110; 56-344.
DR   IntAct; O09110; 2.
DR   STRING; O09110; -.
DR   PhosphoSite; O09110; -.
DR   PRIDE; O09110; -.
DR   Ensembl; ENSMUST00000019076; ENSMUSP00000019076; ENSMUSG00000018932.
DR   GeneID; 26397; -.
DR   KEGG; mmu:26397; -.
DR   CTD; 5606; -.
DR   MGI; MGI:1346868; Map2k3.
DR   eggNOG; roNOG15456; -.
DR   InParanoid; O09110; -.
DR   OMA; MIEMAIL; -.
DR   OrthoDB; EOG4P2Q2M; -.
DR   PhylomeDB; O09110; -.
DR   BRENDA; 2.7.12.2; 3474.
DR   NextBio; 304347; -.
DR   ArrayExpress; O09110; -.
DR   Bgee; O09110; -.
DR   CleanEx; MM_MAP2K3; -.
DR   Genevestigator; O09110; -.
DR   GermOnline; ENSMUSG00000018932; Mus musculus.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000187; P:activation of MAPK activity; IDA:MGI.
DR   GO; GO:0060048; P:cardiac muscle contraction; IMP:MGI.
DR   GO; GO:0006954; P:inflammatory response; IMP:MGI.
DR   GO; GO:0042035; P:regulation of cytokine biosynthetic process; IMP:MGI.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; MOUSE11.PE1363; -.
KW   ENSMUSG000000189325old_1320000031; ENSMUSP000000190761old_1320000031;
KW   Q3TJG7_MOUSE; Q3TLX7_MOUSE; Q3TX82_MOUSE; Q3UDI2_MOUSE; Q5SWN9_MOUSE;
KW   AK011002; AK150067; AK159379; AK166255; AK166507; AK167209; AK167442;
KW   AL603830; BC007467; D87115; X93150;
KW   Acetylation; Alternative splicing; ATP-binding; Complete proteome;
KW   Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   347 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MESPAASPPA SLPQTKGKSK RKKDLRISCV SKPPVSNPTP PRNLDSRTFI TIGDRNFEVE
     ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN TQEQKRLLMD LDINMRTVDC
     FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLEKNMK IPEDILGEIA VSIVRALEHL
     HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL
     NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADQFSPEFVD
     FTSQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
//

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