(data stored in ACNUC8465 zone)

HOGENOM: MOUSE11_PE1505

ID   MOUSE11_PE1505                       STANDARD;      PRT;   397 AA.
AC   MOUSE11_PE1505; P47809;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;
DE   Short=MAP kinase kinase 4; Short=MAPKK 4; EC=2.7.12 2;AltName: Full=C-JUN
DE   N-terminal kinase kinase 1; Short=JNK kinase 1; Short=JNKK 1;AltName:
DE   Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4; Short=MEK
DE   4;AltName: Full=SAPK/ERK kinase 1; Short=SEK1; (MOUSE11.PE1505).
GN   Name=Map2k4; Synonyms=Jnkk1, Prkmk4, Sek1, Serk1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE11.PE1505.
CC       Mus musculus chromosome 11 NCBIM37  sequence 1..121843856 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K4_MOUSE
CC   -!- FUNCTION: Dual specificity kinase that activates the JUN kinases
CC       MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not
CC       MAPK1 (ERK2) or MAPK3 (ERK1).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with SPAG9. Interacts with ARRB2 (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Expressed abundantly in the adult brain and
CC       muscle.
CC   -!- PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase
CC       kinases (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000033352;ENSMUST00000046963;ENSMUSP00000041282.
DR   EMBL; AK036928; - ;
DR   EMBL; AK044534; - ;
DR   EMBL; AK044698; - ;
DR   EMBL; AL662895; - ;
DR   EMBL; AL663069; - ;
DR   EMBL; BC029833; - ;
DR   EMBL; U18310; - ;
DR   UniProtKB/Swiss-Prot; P47809; -.
DR   EMBL; U18310; AAB81554.1; -; mRNA.
DR   IPI; IPI00112335; -.
DR   PIR; S52423; S52423.
DR   RefSeq; NP_033183.1; NM_009157.4.
DR   UniGene; Mm.412922; -.
DR   ProteinModelPortal; P47809; -.
DR   SMR; P47809; 93-386.
DR   DIP; DIP-869N; -.
DR   IntAct; P47809; 1.
DR   STRING; P47809; -.
DR   PhosphoSite; P47809; -.
DR   PRIDE; P47809; -.
DR   Ensembl; ENSMUST00000046963; ENSMUSP00000041282; ENSMUSG00000033352.
DR   GeneID; 26398; -.
DR   KEGG; mmu:26398; -.
DR   CTD; 6416; -.
DR   MGI; MGI:1346869; Map2k4.
DR   eggNOG; roNOG13764; -.
DR   InParanoid; P47809; -.
DR   OMA; VMKSNDC; -.
DR   PhylomeDB; P47809; -.
DR   BRENDA; 2.7.12.2; 3474.
DR   NextBio; 304351; -.
DR   ArrayExpress; P47809; -.
DR   Bgee; P47809; -.
DR   CleanEx; MM_MAP2K4; -.
DR   Genevestigator; P47809; -.
DR   GermOnline; ENSMUSG00000033352; Mus musculus.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000165; P:MAPKKK cascade; IPI:MGI.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; MOUSE11.PE1505; -.
KW   ENSMUSG000000333525old_1320000031; ENSMUSP000000412821old_1320000031;
KW   Q543X6_MOUSE; Q8K2U0_MOUSE; AK036928; AK044534; AK044698; AL662895;
KW   BC029833; U18310;
KW   Acetylation; ATP-binding; Complete proteome; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   397 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAPSPSGGG GSGGGGGTPG PIGPPASGHP AVSSMQGKRK ALKLNFANPP VKSTARFTLN
     PNTTGVQNPH IERLRTHSIE SSGKLKISPE QHWDFTAEDL KDLGEIGRGA YGSVNKMVHK
     PSGQIMAVKR IRSTVDEKEQ KQLLMDLDVV MRSSDCPYIV QFYGALFREG DCWICMELMS
     TSFDKFYKYV YSVLDDVIPE EILGKITLAT VKALNHLKEN LKIIHRDIKP SNILLDRSGN
     IKLCDFGISG QLVDSIAKTR DAGCRPYMAP ERIDPSASRQ GYDVRSDVWS LGITLYELAT
     GRFPYPKWNS VFDQLTQVVK GDPPQLSNSE EREFSPSFIN FVNLCLTKDE SKRPKYKELL
     KHPFILMYEE RTVEVACYVC KILDQMPATP SSPMYVD
//

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