(data stored in ACNUC29662 zone)

HOGENOM: MOUSE11_PE2067

ID   MOUSE11_PE2067                       STANDARD;      PRT;   712 AA.
AC   MOUSE11_PE2067; Q5SVL6; Q3KNA3; Q3V3L0; Q80TL8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rap1 GTPase-activating protein 2; Short=Rap1GAP2;AltName:
DE   Full=GTPase-activating Rap/Ran-GAP domain-like protein 4;
DE   (MOUSE11.PE2067).
GN   Name=Rap1gap2; Synonyms=Garnl4, Kiaa1039, Rap1ga2;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE11.PE2067.
CC       Mus musculus chromosome 11 NCBIM37  sequence 1..121843856 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RPGP2_MOUSE
CC   -!- FUNCTION: GTPase activator for the nuclear Ras-related regulatory
CC       protein RAP-1A (KREV-1), converting it to the putatively inactive
CC       GDP-bound state (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5SVL6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5SVL6-2; Sequence=VSP_029890, VSP_029952;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Contains 1 Rap-GAP domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC65706.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC       Sequence=BAC65706.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
CC   -!- GENE_FAMILY: HOG000231640 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000038807;ENSMUST00000102521;ENSMUSP00000099580.
DR   EMBL; AK038834; - ;
DR   EMBL; AK122424; - ;
DR   EMBL; AL604065; - ;
DR   EMBL; AL627348; - ;
DR   EMBL; AL645971; - ;
DR   EMBL; BC107388; - ;
DR   UniProtKB/Swiss-Prot; Q5SVL6; Q3KNA3; Q3V3L0; Q80TL8; -.
DR   EMBL; AL645971; CAI25407.1; -; Genomic_DNA.
DR   EMBL; AL604065; CAI25407.1; JOINED; Genomic_DNA.
DR   EMBL; AL627348; CAI25407.1; JOINED; Genomic_DNA.
DR   EMBL; AL604065; CAI24516.1; -; Genomic_DNA.
DR   EMBL; AL627348; CAI24516.1; JOINED; Genomic_DNA.
DR   EMBL; AL645971; CAI24516.1; JOINED; Genomic_DNA.
DR   EMBL; AL627348; CAI25645.1; -; Genomic_DNA.
DR   EMBL; AL604065; CAI25645.1; JOINED; Genomic_DNA.
DR   EMBL; AL645971; CAI25645.1; JOINED; Genomic_DNA.
DR   EMBL; BC107388; AAI07389.1; -; mRNA.
DR   EMBL; AK038834; BAE20542.1; -; mRNA.
DR   EMBL; AK122424; BAC65706.1; ALT_SEQ; mRNA.
DR   IPI; IPI00461277; -.
DR   IPI; IPI00875755; -.
DR   RefSeq; NP_001015046.1; NM_001015046.2.
DR   UniGene; Mm.425690; -.
DR   HSSP; P47736; 1SRQ.
DR   ProteinModelPortal; Q5SVL6; -.
DR   SMR; Q5SVL6; 128-460.
DR   PhosphoSite; Q5SVL6; -.
DR   PRIDE; Q5SVL6; -.
DR   Ensembl; ENSMUST00000047488; ENSMUSP00000040180; ENSMUSG00000038807.
DR   Ensembl; ENSMUST00000102521; ENSMUSP00000099580; ENSMUSG00000038807.
DR   GeneID; 380711; -.
DR   KEGG; mmu:380711; -.
DR   UCSC; uc007kbw.1; mouse.
DR   UCSC; uc007kbx.1; mouse.
DR   CTD; 23108; -.
DR   MGI; MGI:3028623; Rap1gap2.
DR   GeneTree; ENSGT00550000074284; -.
DR   InParanoid; Q5SVL6; -.
DR   OMA; IYQKARQ; -.
DR   OrthoDB; EOG42Z4PM; -.
DR   NextBio; 401143; -.
DR   ArrayExpress; Q5SVL6; -.
DR   Bgee; Q5SVL6; -.
DR   CleanEx; MM_GARNL4; -.
DR   Genevestigator; Q5SVL6; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR000331; Rap_GAP.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
DR   HOGENOMDNA; MOUSE11.PE2067; -.
KW   ENSMUSG000000388075old_1320000031; ENSMUSP000000995801old_1320000031;
KW   AK038834; AK122424; AL604065; AL627348; AL645971; BC107388;
KW   Alternative splicing; Complete proteome; Cytoplasm; GTPase activation;
KW   Phosphoprotein; Reference proteome.
SQ   SEQUENCE   712 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLAGLKVKKQ ELANSSDVTL PDRPLSPPLT APPTMKSAEF FEMLEKMQGI KLEEQRPGPQ
     KNKDDYIPYP SIDEVVEKGG PYPLIILPQF GGYWIEDPEN VGTPTSLGSS VYEEEEEDSL
     SPNTFGYKLE CRGEARAYRR HFLGKDHLNF YCTGSSLGNL ILSIKCEEAE GMEYLRIILR
     SKLKTVHERI PLAGLSKLPS VPQIAKAFCD DAVGLKFNPV LYPKASQMIV SYDEHDVNNT
     FKFGVIYQKA RQTLEEELFG NNEESPAFKE FLDLLGDTIT LQDFKGFRGG LDVTHGQTGV
     ESVYTTFRDR EIMFHVSTKL PFTDGDTQQL QRKRHIGNDI VAIIFQEENT PFVPDMIASN
     FLHAYIVVQA DNPGTETPSY KVSVTAREDV PAFGPPLPSP PVFQKGAEFR EFLLTKLTNA
     ENACCKSDKF AKLEDRTRAA LLDNLHDELH THTQVMLGMG PEEDKFENGG HGGFLESFKR
     AIRVRSHSME TMVGSQRKLH GGNLPGSLSG GIVHNSMEVT KTTFSPPVAA ATAKNQSRSP
     IKRRSGLFPR LHSGSEGQGD SRTRCDSASS TPKTPDGGHS SQEIKSETSS NPSSPEICPN
     KEKPFIKLKE NGRANISRSS SSTSSFSSTA GEGEAMEECD SGSSQPSTTS PFKQEVFAYS
     PSPSSESPSL GAAATPIIMS RSPTDAKSRN SPRSNLKFRF DKLSHASSSA GH
//

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