(data stored in ACNUC8465 zone)

HOGENOM: MOUSE11_PE3810

ID   MOUSE11_PE3810                       STANDARD;      PRT;   334 AA.
AC   MOUSE11_PE3810; P70236;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 6;
DE   Short=MAP kinase kinase 6; Short=MAPKK 6; EC=2.7.12 2;AltName:
DE   Full=MAPK/ERK kinase 6; Short=MEK 6;AltName: Full=SAPKK3;
DE   (MOUSE11.PE3810).
GN   Name=Map2k6; Synonyms=Prkmk6, Sapkk3;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE11.PE3810.
CC       Mus musculus chromosome 11 NCBIM37  sequence 1..121843856 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K6_MOUSE
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in MAP kinase p38 exclusively.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Probably activated by dual phosphorylation on
CC       Ser-207 and Thr-211 (By similarity).
CC   -!- PTM: Weakly autophosphorylated. Phosphorylated by TAOK2 (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000020623;ENSMUST00000020949;ENSMUSP00000020949.
DR   EMBL; AK043482; - ;
DR   EMBL; AK077712; - ;
DR   EMBL; AK086722; - ;
DR   EMBL; AK138757; - ;
DR   EMBL; AK141708; - ;
DR   EMBL; AK162671; - ;
DR   EMBL; AL603826; - ;
DR   EMBL; AL691461; - ;
DR   EMBL; BC075652; - ;
DR   EMBL; U39066; - ;
DR   EMBL; X97052; - ;
DR   EMBL; X98067; - ;
DR   UniProtKB/Swiss-Prot; P70236; -.
DR   EMBL; X97052; CAA65764.1; -; mRNA.
DR   EMBL; BC075652; AAH75652.1; -; mRNA.
DR   IPI; IPI00137439; -.
DR   PIR; S71632; S71632.
DR   RefSeq; NP_036073.1; NM_011943.2.
DR   UniGene; Mm.14487; -.
DR   ProteinModelPortal; P70236; -.
DR   SMR; P70236; 44-333.
DR   STRING; P70236; -.
DR   PhosphoSite; P70236; -.
DR   PRIDE; P70236; -.
DR   Ensembl; ENSMUST00000020949; ENSMUSP00000020949; ENSMUSG00000020623.
DR   GeneID; 26399; -.
DR   KEGG; mmu:26399; -.
DR   CTD; 5608; -.
DR   MGI; MGI:1346870; Map2k6.
DR   eggNOG; roNOG06770; -.
DR   InParanoid; P70236; -.
DR   OMA; QTSSTXR; -.
DR   OrthoDB; EOG4P2Q2M; -.
DR   PhylomeDB; P70236; -.
DR   BRENDA; 2.7.12.2; 3474.
DR   Reactome; REACT_21350; Activation of p38 alpha/beta MAPK.
DR   NextBio; 304355; -.
DR   ArrayExpress; P70236; -.
DR   Bgee; P70236; -.
DR   CleanEx; MM_MAP2K6; -.
DR   Genevestigator; P70236; -.
DR   GermOnline; ENSMUSG00000020623; Mus musculus.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000187; P:activation of MAPK activity; IDA:MGI.
DR   GO; GO:0060048; P:cardiac muscle contraction; IMP:MGI.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; MOUSE11.PE3810; -.
KW   ENSMUSG000000206235old_1320000031; ENSMUSP000000209491old_1320000031;
KW   A2AGS2_MOUSE; P70273_MOUSE; Q3UU57_MOUSE; Q543Z5_MOUSE; Q60521_MOUSE;
KW   Q8C371_MOUSE; AK043482; AK077712; AK086722; AK138757; AK141708; AK162671;
KW   AL691461; BC075652; U39066; X97052; X98067;
KW   Acetylation; ATP-binding; Complete proteome; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   334 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIVELG
     RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DVSMRTVDCP FTVTFYGALF
     REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV
     KPSNVLINTL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI
     WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSADFVDF TSQCLKKNSK
     ERPTYPELMQ HPFFTVHESK AADVASFVKL ILGD
//

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