(data stored in ACNUC14577 zone)

HOGENOM: MOUSE11_PE3962

ID   MOUSE11_PE3962                       STANDARD;      PRT;   718 AA.
AC   MOUSE11_PE3962; Q8BMI3; Q3V1Y0; Q80U71;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=ADP-ribosylation factor-binding protein GGA3;AltName:
DE   Full=Golgi-localized, gamma ear-containing, ARF-binding protein 3;
DE   (MOUSE11.PE3962).
GN   Name=Gga3; Synonyms=Kiaa0154;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE11.PE3962.
CC       Mus musculus chromosome 11 NCBIM37  sequence 1..121843856 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:GGA3_MOUSE
CC   -!- FUNCTION: Plays a role in protein sorting and trafficking between
CC       the trans-Golgi network (TGN) and endosomes. Mediates the ARF-
CC       dependent recruitment of clathrin to the TGN and binds
CC       ubiquitinated proteins and membrane cargo molecules with a
CC       cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity).
CC   -!- SUBUNIT: Monomer. Interacts with GGA1 and GGA2. Binds to clathrin
CC       and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the
CC       type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR,
CC       IGF2R/CI-MPR and BACE1. Binds the accessory proteins P56, P200,
CC       SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with
CC       TSG101 and UBC (By similarity).
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       membrane; Peripheral membrane protein (By similarity). Endosome
CC       membrane; Peripheral membrane protein (By similarity).
CC   -!- DOMAIN: The VHS domain functions as a recognition module for
CC       sorting signals composed of an acidic cluster followed by two
CC       leucines (AC-LL motif) (By similarity).
CC   -!- DOMAIN: The GAT domain is responsible for interaction with ARF-
CC       GTP, UBC and RABEP1. Required for recruitment to the TGN it
CC       prevents ARF-GTP hydrolysis (By similarity).
CC   -!- DOMAIN: The unstructured hinge region contains clathrin-binding
CC       and an autoinhibitory (AC-LL) motifs (By similarity).
CC   -!- DOMAIN: The GAE domain binds accessory proteins regulating GGAs
CC       function (By similarity).
CC   -!- PTM: Phosphorylated by CK2 and dephosphorylated by PP2A.
CC       Phosphorylation of GGA3 allows the internal AC-LL motif to bind
CC       the VHS domain and to inhibit the recognition of cargo signals (By
CC       similarity).
CC   -!- PTM: Ubiquitinated (By similarity).
CC   -!- SIMILARITY: Belongs to the GGA protein family.
CC   -!- SIMILARITY: Contains 1 GAE domain.
CC   -!- SIMILARITY: Contains 1 GAT domain.
CC   -!- SIMILARITY: Contains 1 VHS domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC65494.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC   -!- GENE_FAMILY: HOG000231169 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000020740;ENSMUST00000019135;ENSMUSP00000019135.
DR   EMBL; AK031086; - ;
DR   EMBL; AK122212; - ;
DR   EMBL; AK132183; - ;
DR   EMBL; AL645470; - ;
DR   UniProtKB/Swiss-Prot; Q8BMI3; Q3V1Y0; Q80U71; -.
DR   EMBL; AK122212; BAC65494.2; ALT_INIT; mRNA.
DR   EMBL; AK031086; BAC27246.1; -; mRNA.
DR   EMBL; AK132183; BAE21019.1; -; mRNA.
DR   EMBL; AL645470; CAM23010.1; -; Genomic_DNA.
DR   IPI; IPI00403332; -.
DR   RefSeq; NP_766636.2; NM_173048.2.
DR   UniGene; Mm.119479; -.
DR   ProteinModelPortal; Q8BMI3; -.
DR   STRING; Q8BMI3; -.
DR   PhosphoSite; Q8BMI3; -.
DR   PRIDE; Q8BMI3; -.
DR   Ensembl; ENSMUST00000019135; ENSMUSP00000019135; ENSMUSG00000020740.
DR   GeneID; 260302; -.
DR   CTD; 23163; -.
DR   MGI; MGI:2384159; Gga3.
DR   GeneTree; ENSGT00600000084107; -.
DR   InParanoid; Q8BMI3; -.
DR   OrthoDB; EOG4W0XCS; -.
DR   PhylomeDB; Q8BMI3; -.
DR   ArrayExpress; Q8BMI3; -.
DR   Bgee; Q8BMI3; -.
DR   Genevestigator; Q8BMI3; -.
DR   GermOnline; ENSMUSG00000020740; Mus musculus.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR013041; Clathrin/coatomer_app_Ig-like.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR008153; Clathrin_g-adaptin_app.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR004152; GAT.
DR   InterPro; IPR002014; VHS.
DR   InterPro; IPR018205; VHS_subgr.
DR   Gene3D; G3DSA:2.60.40.1230; Clathrin_g-adaptin_app; 1.
DR   Gene3D; G3DSA:1.25.40.90; ENTH_VHS; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   Pfam; PF03127; GAT; 1.
DR   Pfam; PF00790; VHS; 1.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SMART; SM00288; VHS; 1.
DR   SUPFAM; SSF49348; Clath_adapt; 1.
DR   SUPFAM; SSF48464; ENTH_VHS; 1.
DR   PROSITE; PS50180; GAE; 1.
DR   PROSITE; PS50909; GAT; 1.
DR   PROSITE; PS50179; VHS; 1.
DR   HOGENOMDNA; MOUSE11.PE3962; -.
KW   ENSMUSG000000207405old_1320000031; ENSMUSP000000191351old_1320000031;
KW   A2A9W6_MOUSE; Q3V1Y0_MOUSE; AK031086; AK122212; AK132183; AL645470;
KW   Complete proteome; Endosome; Golgi apparatus; Membrane;
KW   Phosphoprotein; Protein transport; Reference proteome; Transport;
KW   Ubl conjugation.
SQ   SEQUENCE   718 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL AHKIQSPQEW
     EAVQALTVLE ACMKNCGRRL HNEVGKFRFL NELIKVVSPK YLGDRVSEKV KTKVIELLFS
     WTLALPEEAK IKDAYHMLKR QGIVQSDPPI PMDRTLIPSP PPRPKNPVFD DEEKSKLLAR
     LLKSKNPDDL QEANRLIKSM VKEDEARIQK VTKRLHTLEE VNNNVKLLHE MLLHYSQEYS
     SDADKELMKE LFDRCENKRR TLFKLASETE DNDNSLGDIL QASDNLSRVI NSYKTIIEGQ
     IVNGEVTTST MPDSEGNSHC GNQGALIDLA ELDAPSNSSP ALAPPTSGIP ILPPPPQTSG
     PPRSRSSSQA EAPPGSDSTN NALSLLDEEL LCLGLTDPAP TAPKESPGSS QWHLFQNEPP
     SDLDFFSPRP VPAASCPSDG PQLPPPVSTS SMSQAPLPAA FPAPVVPASA PTHSTGSFMF
     SSGPAPALAP KAEPKGPEYP SSSTSHRLDA LDQLLEEAKV TSGLVKPVSC FSPGPTASPL
     LPASAPARPL LPFSTGPGSP LFQSQGSPQK GPELSLASVH VPLESIKPSS ALPVTAYDKN
     GFRILFHFAK ECPPGRPDVL VVVVSMLNTA PLPVKSIVLQ AAVPKSMKVK LQPPSGTELS
     PFSPIQPPAA ITQVMLLANP MKEKVRLRYK LTFALGEQLS TELGEVDQFP PVEQWGNL
//

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