(data stored in SCRATCH zone)

HOGENOM: MOUSE11_PE637

ID   MOUSE11_PE637                        STANDARD;      PRT;   660 AA.
AC   MOUSE11_PE637;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Arginyl-tRNA synthetase, cytoplasmic; EC=6.1.1 19;AltName:
DE   Full=Arginine--tRNA ligase; Short=ArgRS; (MOUSE11.PE637).
GN   Name=Rars;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE11.PE637.
CC       Mus musculus chromosome 11 NCBIM37  sequence 1..121843856 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:SYRC_MOUSE
CC   -!- FUNCTION: Forms part of a macromolecular complex that catalyzes
CC       the attachment of specific amino acids to cognate tRNAs during
CC       protein synthesis. Modulates the secretion of AIMP1 and may be
CC       involved in generation of the inflammatory cytokine EMAP2 from
CC       AIMP1 (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + L-arginine + tRNA(Arg) = AMP +
CC       diphosphate + L-arginyl-tRNA(Arg).
CC   -!- SUBUNIT: Interacts (via N-terminus) with AIMP1 (via N-terminus);
CC       this stimulates its catalytic activity. Interacts (via N-terminus)
CC       with LARS2 (via C-terminus). Monomer; also part of a multisubunit
CC       complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu,
CC       Lys, Met and Pro (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: The N-terminus (AA 1-72) has two regions predicted to be
CC       alpha-helical that might be involved in the multisynthetase
CC       complex assembly.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase
CC       family.
CC   -!- GENE_FAMILY: HOG000247212 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000018848;ENSMUST00000018992;ENSMUSP00000018992.
DR   EMBL; AK011383; - ;
DR   EMBL; AK076160; - ;
DR   EMBL; AK149856; - ;
DR   EMBL; AK151168; - ;
DR   EMBL; AK151966; - ;
DR   EMBL; AK152108; - ;
DR   EMBL; AK160216; - ;
DR   EMBL; AK166097; - ;
DR   EMBL; AK168194; - ;
DR   EMBL; AL596084; - ;
DR   EMBL; BC020132; - ;
DR   EMBL; CH466658; - ;
DR   UniProtKB/Swiss-Prot; Q9D0I9; Q3THP2; Q3TM73; Q3U8R2; Q3U930; Q5SXA8; Q8VDW1; -.
DR   EMBL; AK011383; BAB27583.1; -; mRNA.
DR   EMBL; AK076160; BAC36226.1; -; mRNA.
DR   EMBL; AK149856; BAE29127.1; -; mRNA.
DR   EMBL; AK151966; BAE30837.1; -; mRNA.
DR   EMBL; AK152108; BAE30955.1; -; mRNA.
DR   EMBL; AK166097; BAE38569.1; -; mRNA.
DR   EMBL; AK168194; BAE40154.1; -; mRNA.
DR   EMBL; AL596084; CAI24388.1; -; Genomic_DNA.
DR   EMBL; CH466658; EDL16275.1; -; Genomic_DNA.
DR   EMBL; BC020132; AAH20132.1; -; mRNA.
DR   IPI; IPI00315488; -.
DR   RefSeq; NP_080212.2; NM_025936.3.
DR   UniGene; Mm.284906; -.
DR   ProteinModelPortal; Q9D0I9; -.
DR   SMR; Q9D0I9; 56-660.
DR   IntAct; Q9D0I9; 1.
DR   STRING; Q9D0I9; -.
DR   PhosphoSite; Q9D0I9; -.
DR   PRIDE; Q9D0I9; -.
DR   Ensembl; ENSMUST00000018992; ENSMUSP00000018992; ENSMUSG00000018848.
DR   GeneID; 104458; -.
DR   KEGG; mmu:104458; -.
DR   NMPDR; fig|10090.3.peg.23443; -.
DR   UCSC; uc007ilh.2; mouse.
DR   CTD; 5917; -.
DR   MGI; MGI:1914297; Rars.
DR   GeneTree; ENSGT00530000063407; -.
DR   InParanoid; Q9D0I9; -.
DR   OMA; TRFYSNC; -.
DR   OrthoDB; EOG4D52X9; -.
DR   PhylomeDB; Q9D0I9; -.
DR   NextBio; 357144; -.
DR   ArrayExpress; Q9D0I9; -.
DR   Bgee; Q9D0I9; -.
DR   CleanEx; MM_RARS; -.
DR   Genevestigator; Q9D0I9; -.
DR   GermOnline; ENSMUSG00000018848; Mus musculus.
DR   GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR001278; Arg-tRNA-synth_Ia.
DR   InterPro; IPR015945; Arg-tRNA-synth_Ia_core.
DR   InterPro; IPR005148; Arg-tRNA-synth_Ia_N.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_1a_anticodon-bd.
DR   Gene3D; G3DSA:3.30.1360.70; Arg-tRNA-synth_Ic_N; 1.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   PANTHER; PTHR11956; Arg_tRNA-synt_1c; 1.
DR   Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF55190; Arg-tRNA-synth_Ic_N; 1.
DR   SUPFAM; SSF47323; tRNAsyn_1a_bind; 1.
DR   TIGRFAMs; TIGR00456; ArgS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
DR   HOGENOMDNA; MOUSE11.PE637; -.
KW   ENSMUSG000000188485old_1320000031; ENSMUSP000000189921old_1320000031;
KW   Q3TVC5_MOUSE; Q3UAZ3_MOUSE; AK011383; AK076160; AK149856; AK151168;
KW   AK152108; AK160216; AK166097; AK168194; AL596084; BC020132; CH466658;
KW   Acetylation; Aminoacyl-tRNA synthetase; ATP-binding;
KW   Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Phosphoprotein; Protein biosynthesis; Reference proteome.
SQ   SEQUENCE   660 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDGLVAQCSA RLLQQEREIK ALTAEIDRLK NCGCLEASPS LEQLREENLK LKYRLNILRR
     SLQEERRKPT KNMININSRL QEVFGCAIRA AYPDLENPPL IVTPSQQPKF GDYQCNSAMG
     ISQMLKAKEQ KVSPREIAEN ITKHLPNNKY IDKVEIAGPG FINVHLRKDF VSEQLTSLLV
     NGVQLPVLGD KEKVIVDFSS PNIAKEMHVG HLRSTIIGES MSRLFEFAGY DVLRLNHVGD
     WGTQFGMLIA HLQDKFPDYL TVSPPIGDLQ AFYKESKKRF DADEEFKKRA YQCVVLLQSK
     NPDIMKAWNL ICDVSREEFK KIYDALDITL IERGESFYQD RMKDIVKEFE DKGFVQVDDG
     RKIVFVPGCS VPLTIVKSDG GYTYDTSDLA AIKQRLFEEK ANKIIYVVDN GQAIHFQTIF
     AAAQMIGWYD PKVTLVTHVG FGVVLGEDKK KFKTRSGETV RLMDLLEEGL KRSMDKLKEK
     ERDKVLTEEE LKAAQTSVAY GCIKYADLSH NRLNDYIFSF DKMLDDRGNT AAYLLYAFTR
     IRSIARLANI DEAMLQRAAR ETKIILDHEK EWKLGRCILR FPEILQKILD DLFLHTLCDY
     IYELATTFTE FYDSCYCVEK DRQTGKVLKV NMWRMLLCEA VAAVMAKGFD ILGIKPVQRM
//

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