(data stored in ACNUC8465 zone)

HOGENOM: MOUSE12_PE66

ID   MOUSE12_PE66                         STANDARD;      PRT;   196 AA.
AC   MOUSE12_PE66; P62746; P01121; Q9CUV7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rho-related GTP-binding protein RhoB;Flags: Precursor;
DE   (MOUSE12.PE66).
GN   Name=Rhob; Synonyms=Arhb;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE12.PE66.
CC       Mus musculus chromosome 12 NCBIM37  sequence 1..121257530 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RHOB_MOUSE
CC   -!- FUNCTION: Mediates apoptosis in neoplastically transformed cells
CC       after DNA damage. Not essential for development but affects cell
CC       adhesion and growth factor signaling in transformed cells. Plays a
CC       negative role in tumorigenesis as deletion causes tumor formation.
CC       Involved in intracellular protein trafficking of a number of
CC       proteins. Targets PKN1 to endosomes and is involved in trafficking
CC       of the EGF receptor from late endosomes to lysosomes. Also
CC       required for stability and nuclear trafficking of AKT1/AKT which
CC       promotes endothelial cell survival during vascular development.
CC   -!- SUBUNIT: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts
CC       with ARHGEF3 and AKAP13 (By similarity). Interacts with RTKN.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane; Lipid-anchor. Cell
CC       membrane; Lipid-anchor. Nucleus. Note=Late endosomal membrane
CC       (geranylgeranylated form). Plasma membrane (farnesylated form).
CC       Also detected at the nuclear margin and in the nucleus.
CC   -!- INDUCTION: By UV irradiation, N-methyl-N-nitrosourea, cisplatin,
CC       cyclohexamide and serum stimulation.
CC   -!- PTM: Prenylation specifies the subcellular location of RHOB. The
CC       farnesylated form is localized to the plasma membrane while the
CC       geranylgeranylated form is localized to the endosome (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000054364;ENSMUST00000067384;ENSMUSP00000067013.
DR   EMBL; AF481943; - ;
DR   EMBL; AK013784; - ;
DR   EMBL; AK164518; - ;
DR   EMBL; AK167917; - ;
DR   EMBL; BC018275; - ;
DR   EMBL; BC110992; - ;
DR   EMBL; CH466582; - ;
DR   EMBL; CT010379; - ;
DR   EMBL; X99963; - ;
DR   UniProtKB/Swiss-Prot; P62746; P01121; Q9CUV7; -.
DR   EMBL; X99963; CAA68228.1; -; Genomic_DNA.
DR   EMBL; AF481943; AAL89687.1; -; mRNA.
DR   EMBL; BC018275; AAH18275.1; -; mRNA.
DR   EMBL; AK013784; BAB28993.1; -; mRNA.
DR   IPI; IPI00404182; -.
DR   PIR; JC5075; JC5075.
DR   RefSeq; NP_031509.1; NM_007483.2.
DR   UniGene; Mm.687; -.
DR   ProteinModelPortal; P62746; -.
DR   SMR; P62746; 2-185.
DR   MINT; MINT-2982781; -.
DR   STRING; P62746; -.
DR   PhosphoSite; P62746; -.
DR   PRIDE; P62746; -.
DR   Ensembl; ENSMUST00000067384; ENSMUSP00000067013; ENSMUSG00000054364.
DR   GeneID; 11852; -.
DR   KEGG; mmu:11852; -.
DR   CTD; 388; -.
DR   MGI; MGI:107949; Rhob.
DR   eggNOG; roNOG12418; -.
DR   InParanoid; P62746; -.
DR   OMA; DGRAMAM; -.
DR   OrthoDB; EOG4G4GRD; -.
DR   PhylomeDB; P62746; -.
DR   NextBio; 279825; -.
DR   ArrayExpress; P62746; -.
DR   Bgee; P62746; -.
DR   CleanEx; MM_RHOB; -.
DR   Genevestigator; P62746; -.
DR   GermOnline; ENSMUSG00000054364; Mus musculus.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005624; C:membrane fraction; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005625; C:soluble fraction; IDA:MGI.
DR   GO; GO:0019003; F:GDP binding; IDA:MGI.
DR   GO; GO:0005525; F:GTP binding; TAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IDA:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0045786; P:negative regulation of cell cycle; IMP:UniProtKB.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IMP:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   GO; GO:0006927; P:transformed cell apoptosis; IDA:UniProtKB.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; MOUSE12.PE66; -.
KW   ENSMUSG000000543645old_1320000031; ENSMUSP000000670131old_1320000031;
KW   Q3TIC2_MOUSE; Q4FJM5_MOUSE; AF481943; AK013784; AK164518; AK167917;
KW   BC110992; CH466582; CT010379; X99963;
KW   Angiogenesis; Apoptosis; Cell adhesion; Cell membrane;
KW   Complete proteome; Developmental protein; Differentiation;
KW   Direct protein sequencing; Endosome; GTP-binding; Lipoprotein;
KW   Membrane; Methylation; Nucleotide-binding; Nucleus; Palmitate;
KW   Phosphoprotein; Prenylation; Protein transport; Reference proteome;
KW   Transport; Tumor suppressor.
SQ   SEQUENCE   196 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT
     AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD
     LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ
     KRYGSQNGCI NCCKVL
//

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