(data stored in ACNUC4482 zone)

HOGENOM: MOUSE13_PE1626

ID   MOUSE13_PE1626                       STANDARD;      PRT;   1178 AA.
AC   MOUSE13_PE1626; Q62469; Q62163; Q6P1C7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Integrin alpha-2;AltName: Full=CD49 antigen-like family
DE   member B;AltName: Full=Collagen receptor;AltName: Full=Platelet membrane
DE   glycoprotein Ia; Short=GPIa;AltName: Full=VLA-2 subunit alpha;AltName:
DE   CD_antigen=CD49b;Flags: Precursor; (MOUSE13.PE1626).
GN   Name=Itga2;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE13.PE1626.
CC       Mus musculus chromosome 13 NCBIM37  sequence 1..120284312 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ITA2_MOUSE
CC   -!- FUNCTION: Integrin alpha-2/beta-1 is a collagen receptor, being
CC       responsible for adhesion of platelets and other cells to
CC       collagens, modulation of collagen and collagenase gene expression,
CC       force generation and organization of newly synthesized
CC       extracellular matrix. It is also a receptor for laminins, collagen
CC       C-propeptides and E-cadherin. Mice homozygous for a null mutation
CC       in the alpha-2 die very early in embryogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2
CC       associates with beta-1. Interacts with HPS5 and RAB21.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins
CC       with I-domains do not undergo protease cleavage.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC   -!- SIMILARITY: Contains 7 FG-GAP repeats.
CC   -!- SIMILARITY: Contains 1 VWFA domain.
CC   -!- GENE_FAMILY: HOG000059610 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000015533;ENSMUST00000056117;ENSMUSP00000053891.
DR   EMBL; AK036572; - ;
DR   EMBL; BC065139; - ;
DR   EMBL; CH466568; - ;
DR   EMBL; X75427; - ;
DR   EMBL; Z29987; - ;
DR   UniProtKB/Swiss-Prot; Q62469; Q62163; Q6P1C7; -.
DR   EMBL; Z29987; CAA82877.1; -; mRNA.
DR   EMBL; CH466568; EDL18370.1; -; Genomic_DNA.
DR   EMBL; BC065139; AAH65139.1; -; mRNA.
DR   EMBL; X75427; CAA53178.1; -; mRNA.
DR   IPI; IPI00126077; -.
DR   PIR; S44142; S44142.
DR   RefSeq; NP_032422.2; NM_008396.2.
DR   UniGene; Mm.5007; -.
DR   ProteinModelPortal; Q62469; -.
DR   STRING; Q62469; -.
DR   PhosphoSite; Q62469; -.
DR   PRIDE; Q62469; -.
DR   Ensembl; ENSMUST00000056117; ENSMUSP00000053891; ENSMUSG00000015533.
DR   GeneID; 16398; -.
DR   CTD; 3673; -.
DR   MGI; MGI:96600; Itga2.
DR   eggNOG; roNOG09357; -.
DR   InParanoid; Q62469; -.
DR   OrthoDB; EOG45B1DV; -.
DR   ArrayExpress; Q62469; -.
DR   Bgee; Q62469; -.
DR   CleanEx; MM_ITGA2; -.
DR   Genevestigator; Q62469; -.
DR   GermOnline; ENSMUSG00000015533; Mus musculus.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR002035; VWF_A.
DR   Pfam; PF01839; FG-GAP; 1.
DR   Pfam; PF00357; Integrin_alpha; 1.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   PROSITE; PS51470; FG_GAP; 7.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   PROSITE; PS50234; VWFA; 1.
DR   HOGENOMDNA; MOUSE13.PE1626; -.
KW   ENSMUSG000000155335old_1320000031; ENSMUSP000000538911old_1320000031;
KW   Q6P1C7_MOUSE; Q8CB84_MOUSE; AK036572; BC065139; CH466568; X75427; Z29987;
KW   Calcium; Cell adhesion; Complete proteome; Disulfide bond;
KW   Glycoprotein; Integrin; Magnesium; Membrane; Phosphoprotein; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   1178 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGPGQAGGAL LLRLLMLVQG ILNCLAYNVG LPGAKIFSGP SSEQFGYSVQ QLTNPQGNWL
     LVGSPWSGFP ENRMGDVYKC PVDLPTATCE KLNLQNSASI SNVTEIKTNM SLGLTLTRNP
     GTGGFLTCGP LWAHQCGNQY YATGICSDVS PDFQFLTSFS PAVQACPSLV DVVVVCDESN
     SIYPWEAVKN FLVKFVTGLD IGPKKTQVAL IQYANEPRII FNLNDFETKE DMVQATSETR
     QHGGDLTNTF RAIEFARDYA YSQTSGGRPG ATKVMVVVTD GESHDGSKLK TVIQQCNDDE
     ILRFGIAVLG YLNRNALDTK NLIKEIKAIA STPTERYFFN VADEAALLEK AGTLGEQIFS
     IEGTVQGGDN FQMEMAQVGF SADYAPQNDI LMLGAVGAFD WSGTLVQETS HKPVIFPKQA
     FDQVLQDRNH SSFLGYSVAA ISTEDGVHFV AGAPRANYTG QIVLYSVNKQ GNVTVIQSHR
     GDQIGSYFGS VLCSVDVDKD TITDVLLVGA PTYMNDLKKE EGKVYLFTIT KGILNQHQFL
     EGPEGTGNAR FGSAIAALSD INMDGFNDVI VGSPVENENS GAVYIYNGHQ GTIRTKYSQK
     ILGSNGAFRR HLQFFGRSLD GYGDLNGDSI TDVSIGALGQ VIQLWSQSIA DVAIEALFTP
     DKITLLNKDA KITLKLCFRA EFRPAGQNNQ VAILFNMTLD ADGHSSRVTS RGVFRENSER
     FLQKNMVVNE VQKCSEHHIS IQKPSDVVNP LDLRVDISLE NPGTSPALEA YSETVKVFSI
     PFYKECGSDG ICISDLILDV QQLPAIQTQS FIVSNQNKRL TFSVILKNRG ESAYNTVVLA
     EFSENLFFAS FSMPVDGTEV TCEVGSSQKS VTCDVGYPAL KSEQQVTFTI NFDFNLQNLQ
     NQAAINFQAF SESQETNKAD NSVSLTIPLL YDAELHLTRS TNINFYEISS DENAPSVIKS
     VEDIGPKFIF SLKVTAGSAP VSMALVTIHI PQYTKEKNPL LYLTGIQTDQ AGDISCTAEI
     NPLKLPHTAP SVSFKNENFR HTKELDCRTT SCSNITCWLK DLHMKAEYFI NVTTRVWNRT
     FAASTFQTVQ LTAAAEIDTH NPQLFVIEEN AVTIPLMIMK PTEKAEVPTG VIIGSIIAGI
     LLLLAMTAGL WKLGFFKRQY KKMGQNPDEM DETTELNS
//

If you have problems or comments...

PBIL Back to PBIL home page