(data stored in ACNUC24361 zone)

HOGENOM: MOUSE13_PE179

ID   MOUSE13_PE179                        STANDARD;      PRT;   553 AA.
AC   MOUSE13_PE179; Q91VW9; Q3V3Z2; Q8CD81; Q9ESY5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Zinc finger protein with KRAB and SCAN domains 3;AltName:
DE   Full=SCAN-KRAB-zinc finger protein;AltName: Full=Zinc finger protein
DE   306;AltName: Full=Zinc finger protein 307;AltName: Full=Zinc finger
DE   protein 47 homolog; Short=Zf47; Short=Zfp-47; (MOUSE13.PE179).
GN   Name=Zkscan3; Synonyms=Skz1, Zfp306, Zfp307, Zfp47;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE13.PE179.
CC       Mus musculus chromosome 13 NCBIM37  sequence 1..120284312 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ZKSC3_MOUSE
CC   -!- FUNCTION: Acts as a transcriptional regulator. Binds to the
CC       consensus sequence 5'-[GT][AG][AGT]GGGG-3'. Associates with
CC       chromatin at the ITGB4 and VEGF promoters (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in heart, brain, spleen, lung,
CC       liver, skeletal muscle, kidney and testis.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 7 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SIMILARITY: Contains 1 SCAN box domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG00602.1; Type=Frameshift; Positions=421, 432;
CC   -!- GENE_FAMILY: HOG000234619 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000021327;ENSMUST00000070785;ENSMUSP00000068424.
DR   EMBL; AB010353; - ;
DR   EMBL; AF291722; - ;
DR   EMBL; AK013249; - ;
DR   EMBL; AK028902; - ;
DR   EMBL; AK031080; - ;
DR   EMBL; AK031286; - ;
DR   EMBL; BC007473; - ;
DR   EMBL; CH466561; - ;
DR   UniProtKB/Swiss-Prot; Q91VW9; Q3V3Z2; Q8CD81; Q9ESY5; -.
DR   EMBL; AF291722; AAG00602.1; ALT_FRAME; mRNA.
DR   EMBL; AK028902; BAE20446.1; -; mRNA.
DR   EMBL; AK031286; BAC27333.1; -; mRNA.
DR   EMBL; CH466561; EDL32657.1; -; Genomic_DNA.
DR   EMBL; CH466561; EDL32658.1; -; Genomic_DNA.
DR   EMBL; CH466561; EDL32661.1; -; Genomic_DNA.
DR   EMBL; BC007473; AAH07473.1; -; mRNA.
DR   IPI; IPI00228736; -.
DR   RefSeq; NP_001139250.1; NM_001145778.1.
DR   RefSeq; NP_076174.3; NM_023685.4.
DR   UniGene; Mm.296071; -.
DR   HSSP; P08047; 1SP2.
DR   ProteinModelPortal; Q91VW9; -.
DR   SMR; Q91VW9; 43-135, 207-257, 268-535.
DR   STRING; Q91VW9; -.
DR   PRIDE; Q91VW9; -.
DR   GeneID; 72739; -.
DR   KEGG; mmu:72739; -.
DR   UCSC; uc007pqg.2; mouse.
DR   CTD; 80317; -.
DR   MGI; MGI:1919989; Zkscan3.
DR   InParanoid; Q91VW9; -.
DR   OrthoDB; EOG4H19VD; -.
DR   PhylomeDB; Q8CD81; -.
DR   NextBio; 336842; -.
DR   ArrayExpress; Q91VW9; -.
DR   Bgee; Q91VW9; -.
DR   Genevestigator; Q91VW9; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
DR   GO; GO:0016032; P:viral reproduction; IEA:InterPro.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR008916; Retrov_capsid_C.
DR   InterPro; IPR003309; Tscrpt_reg_SCAN.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 7.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 7.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   SUPFAM; SSF47353; Retrov_capsid_C; 1.
DR   PROSITE; PS50805; KRAB; FALSE_NEG.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
DR   HOGENOMDNA; MOUSE13.PE179; -.
KW   ENSMUSG000000213275old_1320000031; ENSMUSP000000684241old_1320000031;
KW   O88252_MOUSE; Q8BSQ2_MOUSE; Q9CSC5_MOUSE; AB010353; AF291722; AK013249;
KW   AK031080; AK031286; BC007473; CH466561;
KW   Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
SQ   SEQUENCE   553 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MARESRESTT LDSHSAEDQM ELLVIKVEQE EASPLAEETS WLGSPGPDRS RQRFRAFRYP
     EAAGPRQALS RLRELCRQWL RPDMHSKEQI LELLVLEQFL TILPGELQAW VREQHPDSGE
     EVVALLEYLD RQLDDTPPQV PDDDDGQELL CSKAVLLTSA QGSESSQMEP VEPLLKQESL
     GSLPSEVRVT HVGHCGEDGV TATRLTSELQ GLLKMEDVAP VLSPRWTEQD SSQMNLYKDG
     MQEHSGSLVS LDQDMQTKVR DLPRAEEYRD QKPEQTVCFL GEDTVPIPTG AEASEQEGKL
     QAAQKSATGT RRFYCRECGK SFAQSSGLSK HKRIHTGLKP YECEECGKAF IGSSALIIHQ
     RVHTGEKPYE CEECGKAFSH SSDLIKHQRT HTGEKPYECD DCGKTFTQSC SLLEHHRIHT
     GEKPYQCNMC PKAFRRSSHL LRHQRTHTGD KDFFVPEPYW ESQSRVESHW ENIETPVSYQ
     CNDCERSFSR ITSLIEHQKV HTGEKPFECQ TCGKGFTRPS YLIQHQRRHT GKKTSVTVTP
     AVHSEVGVQL SLN
//

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